Nexrutine inhibits cancer cell growth as a consequence of mitochondrial damage and mitophagy.

Background/aims: Nexrutine is an herbal extract of Phellodendron amurense and has been used as nutrient supplement in China as well as America. Potential protection effect of Nexrutine has been reported.

Methods: To investigate the mechanism of Nexrutine, we used the HeLa, U2OS and HCT116 as a model.