The study examined how Rosa roxburghii affects insulin resistance and regulates key signaling pathways in obese rats by comparing several treatment groups over a period of 20 weeks.
Five groups of male SD rats were divided into normal control, model, positive control, low-dose, and high-dose Rosa roxburghii, with only the normal control group on a normal diet.
Results showed that the model group had increased body weight and insulin resistance markers, while Rosa roxburghii treatments significantly reduced these markers and improved the signaling proteins involved in glucose regulation.