Publications by authors named "Ying-Peng Huang"
Article Synopsis
- Vascular calcification (VC) in diabetes is driven by the switching of vascular smooth muscle cells to an osteogenic phenotype, which can be mitigated by mitophagy, a process that cleans up damaged mitochondria.
- This study evaluates how the GLP-1 receptor agonist exendin 4 (EX4) impacts mitophagy-related phenotype switching in VSMCs, using T2DM mice models and cultured human cells under high glucose conditions.
- EX4 was found to enhance mitophagy, improve mitochondrial function, and activate the AMPK signaling pathway, which collectively reduced VC in diabetic mice and inhibited the problematic osteogenic differentiation of VSMCs.
microRNA-33a prevents epithelial-mesenchymal transition, invasion, and metastasis of gastric cancer cells through the Snail/Slug pathway.
Am J Physiol Gastrointest Liver Physiol
August 2019
Invasion and metastasis are responsible for the majority of deaths in gastric cancer (GC). microRNA-33a (miR-33a) might function as a tumor suppressor in multiple cancers. Here, we describe the regulation and function of miR-33a in GC and mechanisms involved in epithelial-mesenchymal transition (EMT) and metastasis.
View Article and Find Full Text PDFAim: To explore effects of telomerase RNA-targeting phosphorothioate antisense oligodeoxynucleotides (PS-ASODN) on growth of human gastrointestinal stromal tumors transplanted in mice.
Methods: A SCID mouse model for transplantation of human gastrointestinal stromal tumors (GISTs) was established using tumor cells from a patient who was diagnosed with GIST and consequently had been treated with imatinib. GIST cells cultured for 10 passages were used for inoculation into mice.
Potentially predictive microRNAs of gastric cancer with metastasis to lymph node.
World J Gastroenterol
August 2011
Article Synopsis
- The study aimed to identify and evaluate the expression of 60 microRNAs (miRNAs) in gastric cancer tissues to find potential biomarkers for metastasis.
- The methods involved analyzing 30 gastric cancer tissues and paired normal tissues using a specific technique called stem-loop real-time reverse transcription-polymerase chain reaction, followed by a secondary assessment on 22 more samples.
- Results showed that 38 miRNAs had significantly different expressions in cancer tissues, with miR-212 and miR-195 identified as potential independent biomarkers for predicting lymph node metastasis in gastric cancer due to their high sensitivity and specificity.
Article Synopsis
- The study examined the clinical features, treatments, and outcomes of patients with retroperitoneal paragangliomas over a decade, highlighting challenges in diagnosis and surgical intervention.
- Key findings included a male predominance, common symptoms like abdominal masses, a high misdiagnosis rate on preoperative CT scans, and a notable proportion of functionally active tumors leading to preoperative hypertension.
- The overall 5-year survival rate was 77%, but survival rates dropped significantly after metastasis, indicating the importance of early detection and effective treatment strategies.*
[Effect of adjuvant chemotherapy of ginsenoside Rg3 combined with mitomycin C and tegafur in advanced gastric cancer].
Zhonghua Wei Chang Wai Ke Za Zhi
January 2007
Objective: To evaluate the enhancing effects of ginsenoside Rg3 combined with mitomycin C and tegafur (MF) on postoperative chemotherapy in advanced gastric cancer.
Methods: Seventy-one postoperative patients with advanced gastric cancer were randomly divided into two groups, the control group (n=33), which received treatment with only MF (Mitomycin C+Tegafur), and the trial group (n=38), which were treated with ginsenoside Rg3+MF. The serum VEGF levels in the control group and trial group were detected preoperatively and postoperatively, meanwhile, the serum VEGF levels in 30 healthy persons were detected as comparison.