Publications by authors named "Ying-Lian Shen"
Effects of oxidized low density lipoprotein on transformation of valvular myofibroblasts to osteoblast-like phenotype.
J Huazhong Univ Sci Technolog Med Sci
June 2015
Article Synopsis
- Researchers studied how the Wnt signaling pathway affects the transformation of cardiac valvular myofibroblasts into osteoblast-like cells using porcine aortic valve myofibroblasts exposed to oxidized low-density lipoprotein (ox-LDL).
- The study involved four groups based on the duration of ox-LDL treatment, measuring the expression of specific proteins like α-SMA, BMP2, ALP, and Cbfa-1, finding that their levels significantly increased over time with ox-LDL exposure.
- Blocking the Wnt pathway with Dickkopf-1 led to a decrease in the expression of these proteins, indicating that the Wnt/β-catenin signaling pathway plays