Association between ATG16L1 gene polymorphism and the risk of Crohn's disease.

Objective To perform a meta-analysis to evaluate studies investigating the association between ATG16L1 gene polymorphism and Crohn's disease. Methods PubMed, Embase and Web of Science databases were searched for all studies focusing on the association of ATG16L1 and Crohn's disease. Combined odds ratios with 95% confidence intervals were calculated for four genetic models (allelic model: G allele versus A allele; additive model: GG versus AA; dominant model: GA + GG versus AA; recessive model: GG versus GA + AA) using either a random effects or fixed effects model.

Pretreatment of rat bone marrow mesenchymal stem cells with a combination of hypergravity and 5-azacytidine enhances therapeutic efficacy for myocardial infarction.

Background And Purpose: The in vivo cardiac differentiation and functional effects of unmodified adult bone marrow mesenchymal stem cells (BMSCs) after myocardial infarction (MI) is controversial. Our previous results suggested that hypergravity promoted the cardiomyogenic differentiation of BMSCs, and thus we postulated that ex vivo pretreatment of BMSCs using hypergravity and 5-azacytidine (5-Aza) would lead to cardiomyogenic differentiation and result in superior biological and functional effects on cardiac regeneration of infarcted myocardium.

Methods: We used a rat MI model generated by ligation of the coronary artery.

[Effects of parabolic flight on redox status in SH-SY5Y cells].

Space flight is known to produce a number of neurological disturbances. The etiology is unknown, but it may involve increased oxidative stress. A line of experimental evidence indicates that space flight may disrupt antioxidant defense system and result in increased oxidative stress.

Real-Time, Automatic Detection Of A Small Biomolecule Using The Novel Portable On-line Biomolecules Analyzer.

Previous studies have shown that combined stresses in space flight can affect astronauts' health. On-line monitoring biochemical markers in body fluids which are highly related to some kinds of diseases is a practical method used as the health early alarm and medical care system for astronauts. In this study, a portable on-line biomolecules analyzer (POBA) was developed and utilized for the assay of 2,4-Dinitrophenylhydrazine(DNPH), which offered a portable model for the measurement of low-molecular-weight biochemical markers in body fluids at real-time.

[Disruption of microfilament cytoskeleton induced by simulated microgravity increases the activity of COL1A1 promoter].

It is well known that cytoskeleton system is the sensor of gravity in cells. Under microgravity condition, cytoskeleton is associated with the changes of cell shape, function, signaling and so on; but the relationship between cytoskeleton and gene expression is not fully understood. In present study, we discussed the effects of cell microfilament on the activity of collagen type I alpha 1 chain gene (COL1A1) promoter under microgravity simulated by clinostat and/or cytochalasin B as microfilament depolymerizer in the established EGFP-ROS cell line using the method of fluorescence semi-quantitative analysis and the fluorescent stain of microfilament.

[The design of an anti-rotation reduction internal fixator and its applications in spine fracture surgeries].

This article introduces a new-type anti-rotation reduction internal fixator, which can be applied in various spine fractures and dislocations in order to shorten the operation time, to raise reduction effect, and to reduce the complications such as the loss of reduction, broken nail, broken rod etc. Biomechanical tests and clinical applications have proved that the internal fixator has the features of a short operation time, a definite fixation and few complications.

[Research progress [correction of progresses] of cell culture apparatus].

Cell culture apparatus (CCA) is necessary to space medicine research and space life-science research. With development of technology, CCA has been fully developed. Nowadays, CCA has been used in scientific research and production widely.