[Adsorption behavior of low density lipoprotein on titanium surface].

Purpose: The purpose of this study was to investigate the adsorption of low density lipoprotein (LDL) on titanium surface.

Methods: Pure titanium specimens were soaked with different concentrations of LDL (0, 1, 2 mg/mL). Low density lipoprotein essay was used to analyze the change of LDL adsorption on titanium surface with time going on.

Osseointegration of titanium dental implant under fluoride exposure in rabbits: Micro-CT and histomorphometry study.

Objective: This study aims to investigate the influence of fluoride exposure on implant osseointegration.

Methods: A total of 24 male New Zealand white rabbits were randomly divided into the control group and the fluoride exposure group. Rabbits in the control group were fed with tap water, while those in the fluoride exposure group were given 200 mg/L sodium fluoride solution.

Regulation of osteoblast behaviors via cross-talk between Hippo/YAP and MAPK signaling pathway under fluoride exposure.

Titanium is widely used in implant materials, while excessive fluoride may have negative effects on the osseointegration between the titanium and osteoblasts. Although the underlying mechanisms are still not clear, the mitogen-activated protein kinase (MAPK) or Yes-associated protein (YAP) signaling pathways are thought to be involved. This study evaluated the role of Hippo/YAP and MAPK signaling pathway in osteoblast behaviors under excessive fluoride exposure in vitro and in vivo.

Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3-E1 osteoblasts.

Titanium (Ti) and its corresponding alloys have been widely applied in dental and orthopedic implants. Owing to abrasion and corrosion of implants in the unfavorable electrolytic aqueous environment of the host body, Ti ions could be released from implants and accumulated in local tissues. Recent studies have found that excessive Ti ions were toxic to osteoblasts in adjacent bone tissues and subsequently influenced long-term effects on implant prostheses.