Customized self-expanding bare metal Y stents in the treatment of malignant carinal stenosis: a retrospective analysis.

Background: Self-expanding Y metal stent insertion is a safe and effective palliative method for malignant lesions involving the lower trachea, tracheal carina, and the main-stem bronchi. However, the length and degree of airway stenosis in different patients tend to vary, which leads to a call for a customized Y stent that could achieve a better treatment effect.

Methods: This retrospective analysis included patients who received customized self-expanding bare metallic Y stents for malignant carinal stenosis at Beijing Tiantan Hospital, Capital Medical University between January 2007 and June 2020.

Application of Micro-Tech stents in malignant carinal stenosis.

Malignant carinal stenosis is a disease process that is not always suitable for treatment with a Y-shaped stent. When one of the main bronchi is completely obstructed and cannot be recanalized, or its distal lung tissue has lost function, inserting a Y-shaped stent is infeasible. In this complex condition, a cone-shaped stent is selected to maintain the patency of the trachea and the other main bronchus.

Interventional Bronchoscopic Therapy in Adult Patients with Tracheobronchial Mucoepidermoid Carcinoma.

Background: Tracheobronchial mucoepidermoid carcinoma (MEC) is a rare airway tumor in adults for which surgery is considered a first-line treatment. However, some patients already lost the best opportunity of a surgical intervention when diagnoses are confirmed, and surgery causes considerable trauma resulting in partial loss of pulmonary function. Moreover, the tumor is resistant to radiotherapy and chemotherapy.

Nonstent Combination Interventional Therapy for Treatment of Benign Cicatricial Airway Stenosis.

Background: Benign cicatricial airway stenosis (BCAS) is a life-threatening disease. While there are numerous therapies, all have their defects, and stenosis can easily become recurrent. This study aimed to investigate the efficacy and complications of nonstent combination interventional therapy (NSCIT) when used for the treatment of BCAS of different causes and types.

[The influence of mitomycin C and paclitaxel on the proliferation and apoptosis of human pulmonary fibroblast].

Objective: To observe the inhibitory effect and potential mechanism of mitomycin C and paclitaxel on the proliferation of Human Pulmonary Fibroblast in vitro. So as to providing an experimental reference for the design of drug eluting airway stents.

Methods: Cell viability was measured by MTT assay after different concentrations of mitomycin C or paclitaxel varying from 10(-1)1 mol/L to 10(-4) mol/L had been applied to the fibroblasts for 24, 48 or 72 h, respectively.

[A method for the primary culture of fibroblasts isolated from human airway granulation tissues].

Objective: To establish a feasible method to culture primary fibroblasts isolated from human airway granulation tissues, and therefore to provide experimental data for the investigation of the pathogenesis of benign airway stenosis.

Methods: The granulation tissues were collected from 6 patients during routine bronchoscopy at our department of Beijing Tiantan Hospital from April to June 2011. Primary fibroblasts were obtained by culturing the explanted tissues.

Inhibitory effect of mitomycin C on proliferation of primary cultured fibroblasts from human airway granulation tissues.

Background: Airway granulation tissue and scar formation pose a challenge because of the high incidence of recurrence after treatment. As an emerging treatment modality, topical application of mitomycin C has potential value in delaying the recurrence of airway obstruction. Several animal and clinical studies have already proven its feasibility and efficacy.

[Effect of topical application with mitomycin C in the management of benign cicatricial airway stenosis].

Objective: To assess the efficacy and safety of topical application of mitomycin-C in the management of benign cicatricial airway stenosis (BCAS), and to discuss the feasibility of catheter drip to achieve the topical application of mitomycin-C.

Methods: Twenty patients with BCAS were divided into control group and experimental group (topical application of mitomycin-C). Patients in control group were treated only with interventional bronchoscopy which including balloon dilation, argon plasma coagulation/electrotomy, cryotherapy, stent placement and so on, while patients in experimental group were treated with interventional bronchoscopy adjuncted with topical application of mitomycin-C (0.

[The effects of a domestically made jet ventilator in dogs during interventional procedures by rigid bronchoscopy under general anesthesia].

Objective: To observe the effects of a domestically made jet ventilator in dogs during interventional procedures by rigid bronchoscopy under general anesthesia.

Methods: Ten healthy mongrel dogs were inserted with a rigid bronchoscope under general anesthesia, and the dogs underwent 3 different ventilation conditions randomly: spontaneous breathing alone (group A), and normal frequency jet ventilation with spontaneous breathing (group B), normal frequency jet ventilation without spontaneous breathing (group C). When the interventional procedure lasted 30 min, 60 min, 90 min, 120 min, blood gas analysis was performed.

[Interventional bronchoscopy with the use of mechanical ventilation by larynx mask or tracheal intubation under general anesthesia].

Objective: To explore and evaluate the technique of performing interventional bronchoscopy by using mechanical ventilation with larynx mask or tracheal intubation under general anesthesia.

Methods: From July 2009 to January 2010, 29 patients received interventional bronchoscopy by using mechanical ventilation with larynx mask or tracheal intubation under general anesthesia. Airway pressure and tidal volume before and after bronchoscope insertion, arterial blood gas analysis during interventional bronchoscopy, complications and operation time were recorded.

[A pilot study on interventional bronchoscopy in the management of airway stenosis with benign hyperplasia].

Objective: To evaluate the efficacy of different interventional bronchoscopic techniques for the management of benign cicatricial hyperplasia airway stenosis, and to study the factors associated with the treatment effects.

Methods: From December 2004 to December 2009, 36 patients with cicatricial airway stenosis were admitted to our department. An investigation was made to analyze the effects by different interventional bronchoscopic treatments.

[Evaluation of domestically made recalled nitinol alloy stent implantation for severe airway stenosis].

Objective: it is more difficult and carries more risks to place airway stent under local anaesthesia for the patient with severe airway stenosis. The technique and method of domestically made recalled nitinol alloy stent implantation for severe airway stenosis was explored and evaluated.

Methods: by using bronchoscopy via larynx mask, trachea intubation, or rigid bronchoscope under general anaesthesia and mechanical ventilation, stents are placed in the airway of patients with severe airway stenosis for which had been difficult to performed under local anaesthesia.

[The inhibition effect of paclitaxel on the proliferation of human pulmonary fibroblasts].

Objective: To observe the influence of paclitaxel on the proliferation of human pulmonary fibroblast (HPF), and therefore to explore the possible effect on granulation tissue formation in-stent restenosis after airway stent.

Methods: The HPFS were divided into 3 groups: 24 h group, 48 h group and 72 h group, and there were 3 different dosage groups in each time group. MTT assay was used for detecting cell proliferation.

Effect of three interventional bronchoscopic methods on tracheal stenosis and the formation of granulation tissues in dogs.

Background: Therapeutic approaches for tracheal stenosis caused by the formation of exuberant granulation tissues usually include electrocautery, mechanical dilation, laser therapy, argon plasma coagulation (APC), cryotherapy and stent placement. However, restenosis after stent insertion remains a significant limitation. We examined the efficacy of three different approaches, including induction of mechanical lesions, APC performed with different powers or durations and cryotherapy, to identify the method that limited the formation of granulation tissue.