Complement depletion with cobra venom factor alleviates acute hepatic injury induced by ischemia‑reperfusion.

Increasing evidence has demonstrated that complement activation is required for ischemia‑reperfusion injury (IRI)‑induced hepatic damage, and cobra venom factor (CVF) can deplete the complement components. The aim of the current study was to investigate the effect and intrinsic mechanism of CVF pretreatment on IRI‑induced acute hepatic injury in rats. Acute hepatic injury in rats was induced by bone fracture to simulate trauma, followed by hemorrhage for 90 min, and then the rats were resuscitated for a period of 20 min of reperfusion.

Necroptosis regulated proteins expression is an early prognostic biomarker in patient with sepsis: a prospective observational study.

Background And Aim: Increasing researchers indicate that necroptosis is playing an important role in the regulation of systemic inflammatory response syndrome. The current study was to investigate the prognostic biomarker of the regulated proteins of necroptosis in sepsis patients.

Results: One hundred and twenty-four patients were divided into three groups: 43 patients (34.

Interleukin-18 and miR-130a in severe sepsis patients with thrombocytopenia.

Background: Thrombocytopenia is one of the most common laboratory abnormalities encountered in patients with severe sepsis. It has been reported that thrombocytopenia is linked to mortality in patients with severe sepsis. However, the mechanism of thrombocytopenia in sepsis is unknown.