Synthesis and evaluation of 2-(2'-((dimethylamino)methyl)-4'-(2-fluoroethoxy-substituted)phenylthio)benzenamine derivatives as potential positron emission tomography imaging agents for serotonin transporters.

A series of diphenylsulfide derivatives with various substitutions at the 4-position on phenyl ring A and different lengths of the 2-fluoroethoxy-substituted side-chain at the 4'-position on ring B were synthesized and evaluated as potential positron emission tomography (PET) imaging agents for serotonin transporters (SERT). These ligands exhibited high SERT binding affinities (K = 0.11-1.

Identification of Buctopamine and Mebuctopamine, a β Receptor Agonist and Its Metabolite, in Swine Hair and Feed Additives.

4-[2-(t-Butylamino)-1-hydroxyethyl]phenol (buctopamine, 4), a new β receptor agonist (β-agonist), was found to be an adulterant in feed additives for swine in Taiwan, where using β-agonists in food-production animals is prohibited. Buctopamine and its metabolite, 4-[2-(t-butylamino)-1-hydroxyethyl]-2-methoxyphenol (mebuctopamine, 2), were detected in swine hair specimens. Authentic compounds 2 and 4 were synthesized with 98.