Vasculoprotective effects of , and decoction via the NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats.

Background And Aim: , and decoction (CJID) is efficacious for hypertension. NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX)-induced reactive oxygen species (ROS) generation modulates nuclear factor kappa B (NF-κB) activation and thus mediates hypertension-induced vascular remodeling. This research aims to investigate the anti-remodeling effect of CJID through the mechanism of NOXs-ROS-NF-κB pathway in spontaneously hypertensive rats (SHRs).

Retraction: The unanimity of fluid restriction is still debating in patients with heart failure.

The paper entitled "The unanimity of fluid restriction is still debating in patients with heart failure" by Chen et al., which was published online on April 21, 2020, has been withdrawn by the Publisher because it commented an article by Dr. De Vecchis et al.

Ascending Aortic Aneurysm After Repair of Aortico-Left Ventricular Tunnel.

Ascending aortic aneurysm following aortico-left ventricular tunnel (ALVT) repair is an uncommon but life-threatening complication. A 27-year-old man had received patch closure for ALVT at infancy. Eighteen years later, aortic valve replacement for severe aortic regurgitation and direct suture for recurrent slit tunnel were performed.

A case report of a teenager with severe hand, foot, and mouth disease with brainstem encephalitis caused by enterovirus 71.

Background: Hand, foot, and mouth disease (HFMD) is an acute viral infection occurring mostly in infants and children. Enterovirus 71 (EV71) infection mostly occurs in children < 5 years of age. Severe cases, however, are usually encountered in children under the age of 3 years, and exceedingly rare in teenagers > 14 years and adults.

Significance of preoperative acute kidney injury in patients with acute type A aortic dissection.

Background/purpose: Acute type A aortic dissection (AAD) is a medical emergency with high mortality even with emergency repair. We explored the risk factors for in-hospital mortality and the impact of preoperative acute kidney injury (AKI) in patients with AAD.

Methods: Our hospital database contained records for 156 consecutive patients who underwent AAD repair between March 2000 and February 2013.

Fate of distal aorta after acute type A aortic dissection repair: Change and persistency of postoperative false lumen status.

Background: The role of false lumen patency related to aortic growth, re-interventions, and post-discharge mortality in the chronic phase of repaired type A acute aortic dissection (TAAAD) remains controversial. We investigated the role of postoperative false lumen patency during long-term follow-up.

Methods: Based on postoperative CT images of 70 candidates, 58 eligible patients without alteration of false lumen status were assigned into three groups: complete patency, partial patency, and complete thrombosis.

Indonesian herbal medicine prevents hypertension-induced left ventricular hypertrophy by diminishing NADPH oxidase-dependent oxidative stress.

Indonesian herbal medicine , and decoction (CJID) are known to be efficacious for hypertension. Oxidative stress plays an important role in hypertension-induced left ventricular hypertrophy (H-LVH). This study evaluated whether CJID inhibit cardiac remodeling in spontaneously hypertensive rats (SHRs) through mechanism of oxidative stress-related cardiac-NADPH oxidase (NOXs) pathway: NOX1, NOX2 and NOX4.

Pharmacogenetic dosing of warfarin in the Han-Chinese population: a randomized trial.

Aim: This study aimed to determine clinical utility of genotype-guided dosing for warfarin in Han-Chinese.

Methods: A total of 320 patients were randomly assigned International Warfarin Pharmacogenetic Consortium algorithm, Taiwan algorithm and optimal clinical care arms. The primary outcome of the study was the percentage of time in the therapeutic range during the first 90 days of treatment.

Double right coronary artery and its clinical implications.

Congenital anomalies of the coronary arteries are present in 0.2-1.4% of the general population.

Stable haemodynamics associated with no significant electrocardiogram abnormalities is a good prognostic factor of survival for acute type A aortic dissection repair.

Objectives: Acute type A aortic dissection (AAD) is a medical emergency with high mortality even with emergency repair. We explored the prognostic factors of in-hospital mortality for AAD repair.

Methods: One hundred and thirty-three consecutive patients operated on for AAD between 1997 and 2011 were enrolled in our study.

Acute aortic dissection: an update.

The aorta, which has a complex intrinsic biology and sophisticated mechanical properties for conducting the blood ejected from the left ventricle to the rest of the systemic arterial bed, is the largest and strongest artery in the body. It carries roughly 200 million liters of blood in an average lifetime. Any process that undermines the architecture threatens the structure, stability, and functionality of the aorta.

Double right coronary artery or split right coronary artery?

The prevalence of congenital anomalies of the coronary arteries (CAAs) is reported to be approximately 0.2-1.4% of the general population.