Metagenomics and metabolomics to investigate the effect of Amygdalus mongolica oil on intestinal microbiota and serum metabolites in rats.

Background: Renal fibrosis (RF) is an inevitable consequence of multiple manifestations of progressive chronic kidney diseases (CKDs). Mechanism of Amygdalus mongolica (Maxim.) in the treatment of RF needs further investigation.

Metabolomics reveal the mechanism for anti-renal fibrosis effects of an -butanol extract from .

To reveal the mechanism of anti-renal fibrosis effects of an -butanol extract from renal fibrosis was induced with unilateral ureteral obstruction (UUO) and then treated with an -butanol extract (BUT) from (Rosaceae). Sixty male Sprague-Dawley rats were randomly divided into the sham-operated, renal fibrosis (RF) model, benazepril hydrochloride-treated model (1.5 mg kg) and BUT-treated (1.

Metabolomic assessment of mechanisms underlying anti-renal fibrosis properties of petroleum ether extract from .

Context: The petroleum ether extract (PET) of (Maxim.) Ricker (Rosaceae) has an ameliorative effect on renal fibrosis (RF).

Objective: To evaluate the antifibrotic effects of seeds PET on RF by serum metabolomics, biochemical and histopathological analyses.

Protective effects of Amygdalus mongolica on rats with renal fibrosis based on serum metabolomics.

Ethnopharmacological Relevance: Renal fibrosis (RF) is a common outcome of various progressive chronic kidney diseases (CKDs) and, thus, seriously endangers human health. As the active ingredient of Amygdalus mongolica, amygdalin inhibits RF. Furthermore, our previous studies demonstrated that n-butanol extract (BUT) and petroleum ether extract (PET), which are effective components of A.