Publications by authors named "Ying-Bo Zhou"

Objective: Although extensive research has been carried out on CD4T cells infiltrating the labial glands in patients with primary Sjögren's Syndrome (pSS), it is still unclear how CD4T cells remain in the labial gland tissue and develop into tissue resident cells. The aim of this study was to investigate the molecular mechanism by which CD4T reside in labial glandular tissue of pSS patients.

Methods: Lymphocyte infiltration in labial salivary glands (LSG) of pSS patients was detected by H&E staining.

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with complex genetic predisposing factors involved. PU.1 is an important member of the ETS transcription factors family which has diverse functions such as regulating the proliferation, differentiation of immune cells and multiple inflammatory cytokines.

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Background: Overexpression of CD40 has been reported in patients with primary Sjögren's syndrome (pSS). The increased CD40 expression promote autoimmune response and enhance inflammation in pSS. The aim of this study is to block CD40-CD154 interaction with CD40 DNA vaccine to slow the disease progression of SS in non-obese diabetic (NOD) mice.

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