Publications by authors named "Ying Zhuan Zhan"
Objective: Metastases and invasion are the main reasons for oncotherapy failure. Momordica cochinchinensis (Mu Bie Zi in Chinese) had been used for a variety of purposes, and shown anti-cancer action. In this article, we focused on effects on regulation of breast cancer cell ZR-75-30 metastases and invasion by extracts of Momordica cochinchinensis seeds (ESMCs).
View Article and Find Full Text PDFObjective: To investigate the effects of Bai-Chuan capsule (BC) on the left ventricular hypertrophy in spontaneously hypertensive rats (SHR).
Methods: Taking SHR and Wistar Kyoto rats (WKY) as the model group and the control group respectively, Captopril as positive drug, administered BC 0.3 g/kg, Captopril 3.
Article Synopsis
- Store-operated Ca(2+) entry (SOCE) is thought to play a role in calcium influx in vascular smooth muscle cells, and the study explored how this relates to the vasodilatory effects of imperatorin, a dietary compound.
- The researchers conducted experiments on rat mesenteric arteries and VSMCs, using both measurement of isometric tension and confocal microscopy to assess calcium levels.
- Despite imperatorin causing vasodilation, the study found that it does not inhibit SOCE-induced calcium increases or contractions, suggesting that the vasodilation effect is not due to the SOCE mechanism, and it shares similarities with the effects of nifedipine.
The furanocoumarin imperatorin has been reported to have hypotensive effect, and we have investigated its activity on myocardial hypertrophy. Imperatorin displayed similar chromatographic retention peak to verapamil in the model of cardiac muscle/cell membrane chromatography, and could reduce in a concentration-dependent way protein content and cell size of myocytes prestimulated with angiotensin II. The ratio of heart weight to body weight (mg/g) (4.
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