Development and validation of machine learning-based prediction model for outcome of cardiac arrest in intensive care units.

Cardiac arrest (CA) poses a significant global health challenge and often results in poor prognosis. We developed an interpretable and applicable machine learning (ML) model for predicting in-hospital mortality of CA patients who survived more than 72 h. A total of 721 patients were extracted from the Medical Information Mart for Intensive Care IV database, divided into the training set (n = 576) and the internal validation set (n = 145).

Applications of membrane technology in the resource recovery of power lithium-ion battery precursor wastewater: A review.

New energy materials and technologies are developing rapidly, and the sales of electric vehicles are increasing significantly. The cathode material is the core of electric vehicle batteries. The production of electrode precursors generates a large amount of wastewater.

Natural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.

Ulcerative colitis (UC) is an autoimmune disease with an incompletely understood pathogenesis. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and more studies demonstrated that JAK/STAT signaling pathway is associated with the pathogenesis of UC.

Effect of Salt Reduction Interventions in Lowering Blood Pressure and Salt Intake in Zhejiang Province, China, 2017-2021: A Randomized Controlled Trial.

Background: Addressing high-salt diets in China through interventions can significantly reduce blood pressure (BP) and the associated health risks.

Objective: This study aims to evaluate the effectiveness of a comprehensive salt reduction intervention implemented across counties in Zhejiang Province, focusing on system establishment, extensive publicity, and targeted population interventions.

Methods: The Salt Reduction and Hypertension Prevention Project was initiated in Zhejiang Province.

The Effect of Protein-Starch Interaction on the Structure and Properties of Starch, and Its Application in Flour Products.

Grains are an energy source for human beings, and the two main components-starch and protein-determine the application of grains in food. The structure and properties of starch play a decisive role in determining processing characteristics, nutritional properties, and application in grain-based foods. The interaction of proteins with starch greatly affects the structure, physicochemical, and digestive properties of the starch matrix.

A J-Domain Protein J3 Antagonizes ABI5-BINDING PROTEIN2 to Regulate CONSTANS Stability and Flowering Time.

CONSTANS (CO) plays a vital role in activating the expression of the florigen FT during photoperiod-dependent flowering. The diurnal oscillation of CO protein abundance is strictly controlled by daylength and the circadian clock. We showed previously that ABI5-BINDING PROTEIN2 (AFP2) represses CO expression to delay flowering.

Design of an ultrasound appointment system based on a patient-centered real-time dynamic resource allocation strategy.

Introduction: The existing ultrasound appointment system faces multiple challenges, including a lack of diversity in its operation modes, sluggish efficiency, and limited flexibility. During emergency situations, such as disease outbreaks or severe disaster events, the demand for ultrasound examinations skyrockets, making it imperative to offer patients efficient and user-friendly ultrasound appointment services.

Methods: This study introduces the application of a patient-centered real-time dynamic resource allocation strategy in an ultrasound appointment system.

Copper contamination determined the impact of phages on microbially-driven nitrogen cycling in coastal wetland sediments.

Phages have garnered increasing attention due to their potential roles in biogeochemical cycling. However, their impacts on nitrogen cycling have primarily been inferred from the presence of putative auxiliary metabolic genes (AMGs) and the virus-host linkage, despite of very limited direct experimental evidence. In this study, a series of microcosms were established with the inoculation of either native or non-native phages to simulate coastal wetlands with different phage sources and different levels of copper (Cu) contamination.

Impact of early CVP monitoring on 1-year mortality in patients with congestive heart failure in the ICU: a retrospective analysis based on the MIMIC-IV2.2 database.

Background: Central venous pressure (CVP) monitoring is critical for fluid management in critically ill patients. This study evaluated the impact of CVP monitoring on 1-year mortality in intensive care unit (ICU) patients with congestive heart failure (CHF).

Methods: Data from the Medical Information for Critical Care IV (MIMIC-IV) database were analyzed for ICU patients admitted for the first time with a stay > 24 h.

Recurrent laryngeal nerve thermal injury in radiofrequency ablation for papillary thyroid carcinoma and related risk factors: a prospective large cohort study.

Objective: To establish a prediction model for recurrent laryngeal nerve thermal injury (RLNTI) in radiofrequency ablation (RFA) of papillary thyroid carcinoma (PTC).

Materials And Methods: This prospective study was conducted at a single center from July 2016 to September 2022. Patients diagnosed with PTC and received US-RFA by different interventional therapy groups were enrolled, and classified as derivation cohort and validation cohort based on therapy groups.

Spatial top-down proteomics for the functional characterization of human kidney.

Background: The Human Proteome Project has credibly detected nearly 93% of the roughly 20,000 proteins which are predicted by the human genome. However, the proteome is enigmatic, where alterations in amino acid sequences from polymorphisms and alternative splicing, errors in translation, and post-translational modifications result in a proteome depth estimated at several million unique proteoforms. Recently mass spectrometry has been demonstrated in several landmark efforts mapping the human proteoform landscape in bulk analyses.

Single-cell eQTL mapping reveals cell subtype-specific genetic control and mechanism in malignant transformation of colorectal cancer.

Colorectal cancer (CRC) is a heterogeneous disease that develops through a stepwise accumulation, yet the underlying mechanisms at single-cell resolution remain unclear. Here, we profiled 751,531 single-cell transcriptomes, spatial transcriptomics, and snMultiomes from 142 multistage samples, revealing the cellular and molecular alterations and dynamic intercellular crosstalk during CRC development. Additionally, we created a CRC sc-eQTL map identifying 16,833 significant pairs across 28 cell subtypes, with over 76% of sc-eQTLs being cell-type-specific and fewer than 15% detectable in bulk datasets.

Chaihu Shugan San Exerts Antidepressant Effects by Regulating Glucocorticoid Metabolism in CUMS Rats and Network Pharmacology Provides Complementary Mechanistic Insights.

Traditional Chinese medicine Chaihu Shugan San (CSGS) is a classic Chinese herb prescription for improving depression, but its specific molecular mechanism has not been fully clarified. This study integrates network pharmacology and experimental validation to investigate CSGS's antidepressant effects, focusing on its impact on GC metabolism and related pathways. In this research, the antidepressant mechanism of CSGS in relation to the depression model induced by chronic unpredictable mild stress will be discussed.

Associations of triglyceride glucose-body mass index and the combination of sedentary behavior and physical activity with risks of all-cause mortality and myocardial infarction: a cohort study from the UK biobank.

Background: Triglyceride glucose-body mass (TyG-BMI) index, sedentary behavior (SB) and physical activity (PA) are independently associated with all-cause mortality and myocardial infarction (MI). However, it remains unclear whether TyG-BMI index and the combination of SB and PA exhibit joint effects on all-cause mortality and MI.

Methods: Among 502 356 participants from the UK Biobank, 297 761 eligible participants were selected.

HFPEF and HFA-PEFF scores for heart failure risk stratification in hypertrophic cardiomyopathy patients.

Aims: HFPEF and HFA-PEFF scores have demonstrated prognostic value in heart failure (HF) with preserved ejection fraction. This study aimed to explore the value of the HFPEF and HFA-PEFF scores for HF risk stratification in patients with hypertrophic cardiomyopathy (HCM).

Methods And Results: In this cohort study, 1068 HCM patients were included.

Synchrotron-Based X-Ray Molecular Probes for Imaging in Intelligent Biomedicine.

With the construction and operational launch of third-generation synchrotron radiation sources, X-ray molecular probe technology is actively explored and developed, playing an increasingly significant role in modern life sciences. This review provides an overview of synchrotron-based X-ray imaging techniques and emphasizes the applications of X-ray molecular probes across various fields associated with intelligent biomedicine. Building on this foundation, it further discusses future advancements in X-ray molecular probes and forecasts their application trends in intelligent biomedicine, particularly in the realm of personalized treatment.

Mechanism of Bile-Processed Coptidis Rhizoma in the Treatment of Type 2 Diabetes Mellitus in Rats Based on Dissolution Kinetics and Untargeted Metabolomics.

Bile-processed Coptidis Rhizoma (BPCR) exhibits stronger efficacy in treating T2DM than Coptidis Rhizoma(CR) alone. However, the synergistic mechanism of its processing remains unknown. This study utilized HPLC to determine the content and dissolution characteristics of alkaloid components in BPCR before and after processing.

Pharmacological effects and mechanism of Ilexsaponin A1 in modulating platelet function.

Ethnopharmacological Relevance: Ilex pubescens Hook. & Arn. is a traditional Chinese medicine for promoting blood circulation.

LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis.

Osteoarthritis (OA) is a degenerative disease which places an enormous burden on society, effective treatments are still limited. As a non-invasive and safe physical therapy, low-intensity pulsed ultrasound (LIPUS) can alleviate OA progression, but the underlying mechanism is not fully understood, especially the mechanical transduction between LIPUS and the organism. In this pioneering study, the biomechanical effects of LIPUS on living mice chondrocytes and living body zebrafish are investigate by using fluorescence imaging technology, to dynamically "visualize" its invisible mechanical stimuli in the form of calcium oscillations.

Leaf nitrogen allocation to non-photosynthetic apparatus reduces mesophyll conductance under combined drought-salt stress in .

Leaf nitrogen allocation plays a crucial role in determining both photosynthetic function and structural development of plants. However, the effects of drought, salt stress, and their combination on leaf nitrogen allocation, and how these affect mesophyll conductance ( ) and photosynthesis, remain poorly understood. In this study, we first investigated variations in photosynthetic characteristics and leaf nitrogen allocation, and analyzed the relationship between and leaf nitrogen allocation ratios in under drought, salt and combined drought-salt stress.

Achieving Optimal Transfection Conditions in Chicken Primordial Germ Cells Under Feeder- and Serum-Free Medium.

The successful application of primordial germ cells (PGCs) is an ideal method for generating gene-edited birds. However, barriers to efficient DNA transfection in PGCs lead to low transfection efficiency, limiting the generation of genetically modified chickens. The current study utilized chemical transfection and electroporation methods to determine the optimal transfection conditions for the PGC line under feeder- and serum-free medium.

Notch1 siRNA and AMD3100 Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease.

: As a key mechanism of metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, inflammation triggered by chronic liver injury and immune cells with macrophages enables MASLD to progress to an advanced stage with irreversible processes such as fibrosis, cell necrosis, and cancer in the liver. The complexity of MASLD, including crosstalk between multiple organs and the liver, makes developing a new drug for MASLD challenging, especially in single-drug therapy. It was reported that upregulation of Notch1 is closely associated with the function of pro-inflammatory macrophages.

Recent advances and developments in solar-driven photothermal catalytic CO reduction into multicarbon (C) products.

Solar-driven catalytic conversion of carbon dioxide (CO) into value-added C chemicals and fuels has attracted significant attention over the past decades, propelled by urgent environmental and energy demands. However, the catalytic reduction of CO continues to face significant challenges due to inherently slow reduction kinetics. This review traces the historical development and current state of photothermal CO reduction, detailing the mechanisms by which CO is transformed into C products.

FBXW7 Directly Ubiquitinates and Degrades CTNNB1 Mediating the Suppression of ENKUR in Endometrial Cancer.

Enkurin (ENKUR) is a tumor suppressor in some malignancies. However, its role in endometrial cancer (EC) remains unknown. Here, we firstly observed that reduced ENKUR expression promotes progression and poor prognosis in EC.

Annual cycle variations in the gut microbiota of migratory black-necked cranes.

Introduction: Migratory birds exhibit unique annual cycles that complicate their gut microbiota. However, the annual dynamics of gut microbiota in migratory birds remain unclear, hindering our understanding of their environmental adaptation.

Methods: Here, we collected fecal samples from black-necked cranes () across four seasons at their breeding grounds and used wintering ground data from databases to characterize their gut microbial compositions throughout the year.