Molecular and functional characterization of short peptidoglycan recognition proteins in Vesicomyidae clam.

Within cold seep environments, the Vesicomyidae clam emerges as a prevalent species, distinguished by its symbiotic relationship with microorganisms housed within its organ gill. Given the extreme conditions and the symbiotic nature of this association, investigating the host's immune genes, particularly immune recognition receptors, is essential for understanding their role in facilitating host-symbiotic interactions. Three short peptidoglycan recognition proteins (PGRPs) were identified in the clam.

Comparative study of lysine acetylation in Vesicomyidae clam Archivesica marissinica and the manila clam Ruditapes philippinarum: adaptation mechanisms in cold seep environments.

Background: The deep-sea cold seep zone is characterized by high pressure, low temperature, darkness, and oligotrophy. Vesicomyidae clams are the dominant species within this environment, often forming symbiotic relationships with chemosynthetic microbes. Understanding the mechanisms by which Vesicomyidae clams adapt to the cold seep environment is significant.

Effect of Cyclic Warm-Rolling Technique on Mechanical Properties of MoCu30 Thin Plates with Heterogeneous Structure.

By employing a cyclic warm rolling technique, MoCu30 alloy sheets of different thicknesses were prepared to investigate the effects of various rolling reduction rates on the microstructure and mechanical properties of MoCu30 alloys. Additionally, the evolution of microscale heterogeneous deformation during the tensile process was observed based on DIC technology. This study reveals that Mo-Cu interfaces at different deformation rates exhibit an amorphous interlayer of 0.

Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice.

Background: Enhanced glycolysis is a crucial metabolic event that drives the development of liver fibrosis, but the molecular mechanisms have not been fully understood. Lactate is the endproduct of glycolysis, which has recently been identified as a bioactive metabolite binding to G-protein-coupled receptor 81 (GPR81). We then questioned whether GPR81 is implicated in the development of liver fibrosis.

Forming Characteristics of Tailor Rolled Blank of Aluminum Alloy during Three-Point Bending.

This paper presents an investigation on the forming characteristics of the tailor rolled blank of an aluminum alloy (Al-TRB) during three-point bending at room temperature through experiments and finite element simulations. The strain distribution, spring-back characteristics, and metal flow law of 6000 series Al-TRB during three-point bending are explored. The prepared Al-TRB has good bending properties, and no surface cracks appear in the bending region of the Al-TRB when bent to 180°.

Review on Cellular Automata for Microstructure Simulation of Metallic Materials.

The cellular automata (CA) method has played an important role in the research and development of metallic materials. CA can interpret the microstructure changes of materials and obtain more abundant, accurate and intuitive information of microstructure evolution than conventional methods. CA can visually represent the process of grain formation, growth, development and change to us in a graphical way, which can assist us in analysis, thinking and solving problems.

Hydrothermal carbonization of Chinese medicine residues: Formation of humic acids and combustion performance of extracted hydrochar.

Aiming at the sustainable management of high-moisture Chinese medicine residues (CMR), an alternative way integrating hydrothermal carbonization (HTC), humic acids (HAs) extraction and combustion of remained hydrochar has been proposed in this study. Effect of HTC temperature, HTC duration, and feedwater pH on the mass yield and properties of HAs was examined. The associated formation mechanism of HAs during HTC was proposed.

Microstructure and Mechanical Properties of Ti/Al-SiC/Ti Clad Plates Prepared via the Powder-in-Tube Method.

SiC particle-reinforced Ti/Al/Ti clad plates were successfully fabricated by the powder-in-tube method. The surface micrography, element diffusion, peeling strength and tensile property of clad plates were studied after annealing and cold rolling. The experimental results show that 6 wt.

Negative regulation of pro-apoptotic AMPK/JNK pathway by itaconate in mice with fulminant liver injury.

Accumulating evidence indicates that metabolic responses are deeply integrated into signal transduction, which provides novel opportunities for the metabolic control of various disorders. Recent studies suggest that itaconate, a highly concerned bioactive metabolite catalyzed by immune responsive gene 1 (IRG1), is profoundly involved in the regulation of apoptosis, but the underlying mechanisms have not been fully understood. In the present study, the molecular mechanisms responsible for the apoptosis-modulatory activities of IRG1/itaconate have been investigated in mice with lipopolysaccharide (LPS)/D-galactosamine (D-Gal)-induced apoptotic liver injury.

Quantitative evaluation of anisometropic amblyopia treatment efficacy by coupling multiple visual functions via CRITIC algorithm.

Background: The evaluation of amblyopia treatment efficacy is essential for amblyopia prevention, control, and rehabilitation.

Methods: To evaluate the amblyopia treatment efficacy more precisely and quantitatively, this study recorded four visual function examination results, i.e.

Advancing Strategies for Proteolysis-Targeting Chimera Design.

Proteolysis-targeting chimeras (PROTACs) have shown great therapeutic potential by degrading various disease-causing proteins, particularly those related to tumors. Therefore, the introduction of PROTACs has ushered in a new chapter of antitumor drug development, marked by significant advances over recent years. Herein, we describe recent developments in PROTAC technology, focusing on design strategy, development workflow, and future outlooks.

Immune response gene 1 deficiency aggravates high fat diet-induced nonalcoholic fatty liver disease via promotion of redox-sensitive AKT suppression.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder worldwide. Immune response gene 1 (IRG1) catalyzes the production of bio-active itaconate, which is actively involved in the regulation of signal transduction. A recent study has found that the expression of IRG1 was significantly down-regulated in obesity-associated fatty liver, but the potential roles of IRG1 in the development NAFLD remain unclear.

Drying of Chinese medicine residues (CMR) by hot air for potential utilization as renewable fuels: drying behaviors, effective moisture diffusivity, and pollutant emissions.

Unlabelled: High moisture in Chinese medicine residues (CMR) can decrease the energy efficiency of thermochemical conversion, which necessitates the pre-drying. Owing to the complex constituents and decoction, CMR may possess distinct drying characteristics. It is necessary to understand its drying behaviors, effective moisture diffusivity, and pollutant emissions for future design and optimization of an industrial-level dryer.

CaO-assisted hydrothermal treatment combined with incineration of sewage sludge: Focusing on phosphorus (P) fractions, P-bioavailability, and heavy metals behaviors.

Dewatering of sewage sludge (SS) was the prerequisite for saving its drying energy and sustaining its stable combustion. Hydrothermal treatment (HT) has been a promising technology for improving SS dewaterability with high energy efficiency. However, the knowledge of phosphorus (P) transformation and heavy metals (HMs) behaviors in the combined HT and incineration process was still lack.

Activation of GPR81 Aggravates Remote Organ Injury During Hepatic Ischemia-Reperfusion Injury.

Hepatic ischemia-reperfusion injury (HIRI) is a serious situation with high morbidity and mortality, which is usually accompanied with hyperlactatemia due to impaired lactate clearance in liver. G-protein-coupled receptor 81 (GPR81) has recently been identified as the bioactive receptor of lactate. GPR81 is profoundly involved in the modulation of metabolism and inflammation, but its significance in HIRI remains unclear.

A Pyridazinone Compound for Effectively Treating Non-alcoholic Steatohepatitis by Targeting THRβ.

Developing effective therapies and medicines to conquer nonalcoholic steatohepatitis (NASH) is of great significance for public health and is faced with a major challenge. The activation of the thyroid hormone receptor agonist THRβ could be regulated by target drugs that has brought huge potential to the treatment of NASH. In this work, pyridazinone compound YWS01125 was synthesized for the first time.

Immune response gene 1 deficiency impairs Nrf2 activation and aggravates liver fibrosis in mice.

A growing body of evidence suggests that metabolic events play essential roles in the development of liver fibrosis. Immune response gene 1 (IRG1) catalyzes the generation of itaconate, which function as a metabolic checkpoint under several pathological circumstances. In the present study, the hepatic level of IRG1 was determined in mice with carbon tetrachloride (CCl)-induced liver fibrosis.

Risk factors of pulmonary embolism in the elderly patients: a retrospective study.

Aim: We aimed to summarize the clinical feature and risk factors of patients suffering from pulmonary embolism (PE) in the elderly patients, and explore the change in D-dimer after anti-coagulant therapy.

Methods: A total of 426 patients with PE admitted from August 2012 to January 2019 in the Cangzhou Central Hospital were analyzed in this retrospective study. A comparison of clinical features and risk factors was conducted between the elderly group and non-elderly groups.

Correlating phosphorus transformation with process water during hydrothermal carbonization of sewage sludge via experimental study and mathematical modelling.

Recently, hydrothermal carbonization (HTC) based phosphorus (P) recovery from sewage sludge (SS) has attracted considerable interests worldwide. However, they concentrated on P transformation in the hydrochars, while ignored that the variations of process water (PW) might influence P transformation, since it exposed to water thoroughly during HTC. In this study, correlation of P transformation with PW were examined via experimental study and mathematical modelling.

MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling.

Aims: The heart undergoes pathological remodelling under increased stress and neuronal imbalance. MicroRNAs (miRNAs) are involved in post-transcriptional regulation of genes in cardiac physiology and pathology. However, the mechanisms underlying miRNA-mediated regulation of pathological cardiac remodelling remain to be studied.

Rational design of SphK inhibitors using crystal structures aided by computer.

Sphingosine kinases (SphKs) are lipid kinases that catalyze the phosphorylation of sphingosine (Sph) to sphingosine-1-phosphate (S1P). As a bioactive lipid, S1P plays a role outside and inside the cell to regulate biological processes. The overexpression of SphKs is related to a variety of pathophysiological conditions.

Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovitise, and its pathogenesis is complicated. Sphingosine-1-phosphate (S1P) is a lipid produced by sphingosine kinase 1 and 2 (SphK1/2), which participate in some of most-spread skeletal diseases such as rheumatoid arthritis or osteoarthritis. To explore the anti-inflammatory activity of 2-epi-jaspine B analogs as SphKs inhibitors, we used LPS-induced rheumatoid arthritis fibroblast-like synovial cells (HFLS-RA) as the research object to evaluate the anti-inflammatory activity of 16 2-epi-jaspine B analogs and the newly synthesized salt CHJ01.