Effect of soil-groundwater system on migration and transformation of organochlorine pesticides: A review.

Soil is the place where human beings, plants, and animals depend on for their survival and the link between the various ecological layers. Groundwater is an important component of water resources and is one of the most important sources of water for irrigated agriculture, industry, mining and cities because of its stable quantity and quality. Soil and groundwater are important strategic resources highly valued by countries around the world.

Cardiac compressed sensing real-time cine for the assessment of left ventricular function: a large sample size analysis.

Background: Segmented cine imaging using a balanced steady-state free precession sequence is the gold standard for accurately quantifying cardiac function and myocardial mass. However, this method suffers from inefficient K-space sampling, resulting in long scan times, and requires multiple breath holds that can be difficult for some patients. Real-time compressed sensing (CS) cine reduces image acquisition time through K-space undersampling and iterative reconstruction, enabling rapid magnetic resonance (MR) imaging.

Superior Energy-Storage Performances under a Moderate Electric Field Achieved in Antiferroelectric-like NaBiTiO-Based Relaxor Ferroelectric Ceramics by a Synergistic Optimization Strategy.

The progress of power systems and electronic devices promotes the development of lead-free dielectric energy-storage material. Particularly, NaBiTiO-based ferroelectric ceramics featuring large spontaneous polarization as well as wide dielectric adjustability and stability are highly recognized as promising candidates. However, their large remanent polarization () and low electric breakdown strength () result in unsatisfactory recoverable energy density () and/or energy conversion efficiency (η), severely restricting their energy-storage applications.

Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles.

Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, both and . Most of the review literature employs meta-analysis methods to explore the association between dairy intake and breast cancer risk.

BOP2-TE: Bayesian optimal phase 2 design for jointly monitoring efficacy and toxicity with application to dose optimization.

We propose a Bayesian optimal phase 2 design for jointly monitoring efficacy and toxicity, referred to as BOP2-TE, to improve the operating characteristics of the BOP2 design proposed by Zhou. BOP2-TE utilizes a Dirichlet-multinomial model to jointly model the distribution of toxicity and efficacy endpoints, making go/no-go decisions based on the posterior probability of toxicity and futility. In comparison to the original BOP2 and other existing designs, BOP2-TE offers the advantage of providing rigorous type I error control in cases where the treatment is toxic and futile, effective but toxic, or safe but futile, while optimizing power when the treatment is effective and safe.

Ailanthone targets the KMT2A-MEN1 complex to suppress lung metastasis of osteosarcoma.

Background: Lung metastasis is the leading cause of death in patients with osteosarcoma (OS), and new drugs are urgently needed. Epigenetic reprogramming is a recently proposed hallmark of malignancy; therefore, targeting epigenetic enzymes might provide a novel therapeutic strategy for OS lung metastasis. We recently reported that ailanthone (AIL), a natural product isolated from the Chinese medicinal plant Ailanthus altissima, inhibits OS cell growth and induces substantial metabolic changes; however, its direct targets remain unclear.

Laparoscopic Cytoreduction After Neoadjuvant Chemotherapy in High-Grade Epithelial Ovarian Cancer: A LANCE Randomized Clinical Trial.

Importance: Despite the absence of high-quality evidence of its safety and effectiveness, minimally invasive surgery (MIS) is increasingly used to treat advanced epithelial ovarian cancer (EOC).

Objective: To assess the feasibility of conducting a full-scale randomized clinical trial (RCT) designed to compare the efficacy of MIS vs laparotomy in patients with advanced-stage EOC and a complete or partial response to neoadjuvant chemotherapy (NACT).

Design, Setting, And Participants: This lead-in pilot phase of LANCE (Laparoscopic Cytoreduction After Neoadjuvant Chemotherapy), an international, open-label, noninferiority RCT, opened to enrollment in September 2020 and enrolled the 100th eligible patient in February 2023.

Interpretable machine learning model for digital lung cancer prescreening in Chinese populations with missing data.

We developed an interpretable model, BOUND (Bayesian netwOrk for large-scale lUng caNcer Digital prescreening), using a comprehensive EHR dataset from the China to improve lung cancer detection rates. BOUND employs Bayesian network uncertainty inference, allowing it to predict lung cancer risk even with missing data and identify high-risk factors. Developed using data from 905,194 individuals, BOUND achieved an AUC of 0.

Coupling Thiosulfate-Driven denitrification and anammox to remove nitrogen from actual wastewater.

A coupled thiosulfate-driven denitrification and anammox (TDDA) process was established to remove nitrogen from wastewater. It was optimized in an up-flow anaerobic sludge blanket reactor using synthetic wastewater, and its reliability was then verified with actual wastewater. The results demonstrated that nitrate, nitrite, and ammonium could be synergistically removed, and the highest total nitrogen removal efficiency reached 97.

New insights into the stages of cadmium remediation in ryegrass enhanced by kitchen compost-derived dissolved organic matter: Activation, absorption, and storage.

Dissolved organic matter (DOM) regulates plant behavior in both agricultural and environmental fields. However, the regulatory mechanisms by which DOM influences soil-plant system interactions during the phytoremediation of Cd-contaminated soils remain unclear. Therefore, this study investigated the enhanced effect of kitchen compost-derived DOM on the Cd remediation capability of ryegrass across three phases of phytoremediation.

Realizing linear-polarization-decoupled quasi-perfect absorption through mirror-symmetric QR-code metasurfaces.

Metamaterial absorbers (MAs) with irregular structures facilitate the attainment of unique absorption properties, leveraging the extensive geometric freedom. However, a challenge arises from the fact that polarization-dependent spectra do not coincide with cross-polarization. In this study, we introduce a MA featuring a mirror-symmetric quick response (QR)-code structure to achieve linear-polarization-decoupled absorption characteristics.

Hydrogen Spillover-Bridged Interfacial Water Activation of WC and Hydrogen Recombination of Ru as Dual Active Sites for Accelerating Electrocatalytic Hydrogen Evolution.

Tungsten carbide (WC) is a promising alternative to platinum catalysts for hydrogen evolution reaction (HER). However, strong tungsten-hydrogen bond hinders hydrogen desorption while favoring H reduction, thus limiting HER kinetics. Inspired by the phenomenon of hydrogen spillover in heterogeneous catalysis, a ruthenium (Ru) doped-driven activated hydrogen migration from WC surface to Ru is reported.

Predictive slope stability early warning model based on CatBoost.

A model for predicting slope stability is developed using Categorical Boosting (CatBoost), which incorporates 6 slope features to characterize the state of slope stability. The model is trained using a symmetric tree as the base model, utilizing ordered boosting to replace gradient estimation, which enhances prediction accuracy. Comparative models including Support Vector Machine (SVM), Light Gradient Boosting Machine (LGBM), Random Forest (RF), and Logistic Regression (LR) were introduced.

TFE3 and TP53 were novel diagnostic biomarkers related to mitochondrial autophagy in chronic rhinosinusitis with nasal polyps.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) belongs to a subtype of Chronic rhinosinusitis which is a heterogeneous inflammatory condition. It has been reported that mitophagy may provide a new therapeutic option for CRSwNP.

Methods: The GSE136825 (training dataset) and GSE179265 (validation dataset) were scoured from the Gene Expression Omnibus database.

Exosomal miRNA as biomarker in cancer diagnosis and prognosis: A review.

Exosomes, which are extracellular vesicles with a diameter ranging from 40 to 160 nm, are abundantly present in various body fluids. Exosomal microRNA (ex-miR), due to its exceptional sensitivity and specificity, has garnered significant attention. Notably, ex-miR is consistently detected in almost all bodily fluids, highlighting its potential as a reliable biomarker.

Utidelone-based therapy in advanced or metastatic solid tumors after failure of standard therapies: a prospective, multicenter, single-arm trial.

Treatment options are limited for tumors after failure of standard therapies. Utidelone (UTD1), a novel microtubule stabilizer, given via 5 days intermittent infusion, has demonstrated high activity in heavily pretreated metastatic breast cancer, while its efficacy in other cancers was unclear. Peripheral neuropathy is a common and severe adverse event (AE) of UTD1.

Encapsulating Transition Metal Nanoparticles inside Carbon (TM@C) Chainmail Catalysts for Hydrogen Evolution Reactions: A Review.

Green hydrogen energy from electrocatalytic hydrogen evolution reactions (HERs) has gained much attention for its advantages of low carbon, high efficiency, interconnected energy medium, safety, and controllability. Non-precious metals have emerged as a research hotspot for replacing precious metal catalysts due to low cost and abundant reserves. However, maintaining the stability of non-precious metals under harsh conditions (e.