Red fluorescent AIE bioprobes with a large Stokes shift for droplet-specific imaging and fatty liver diagnosis.

Lipid droplets (LDs) as spherical dynamic subcellular organelles, play an important role in various cellular functions such as protein degradation, lipid metabolism, energy storage, signal transduction, and membrane formation. Abnormal function of LDs will lead to a series of diseases and hence monitoring the status of LDs is particularly important. In this study, we synthesized a water-insoluble red fluorescent emitting small molecule fluorescent probe (TPE-TCF), which exhibited aggregation-induced emission (AIE) properties and enabled highly selective real-time imaging of LDs (Pearson's R value was 0.

Self-Produced O CNs-Based Nanocarriers of DNA Hydrophobization Strategy Triggers Photodynamic and Mitochondrial-Derived Ferroptosis for Hepatocellular Carcinoma Combined Treatment.

Hypoxia can aggravate tumor occurrence, development, invasion, and metastasis, and greatly inhibit the photodynamic therapy (PDT) effect. Herein, carbon nitride (CNs)-based DNA and photosensitizer co-delivery systems (BPSCNs) with oxygen-producing functions are developed to address this problem. Selenide glucose (Seglu) is used as the dopant to prepare red/NIR-active CNs (SegluCNs).

Efficient Fenton-like degradation of tetracycline by stalactite-like CuCo-LDO/CN catalysts: The overlooked contribution of dissolved oxygen.

In the Fenton-like processes, the resources that exist in the system itself (e.g., dissolved oxygen, electron-rich pollutants) are often overlooked.

Carbon Nitride-Based siRNA Vectors with Self-Produced O Effects for Targeting Combination Therapy of Liver Fibrosis via HIF-1α-Mediated TGF-β1/Smad Pathway.

Hypoxia is an important feature, which can upregulate the hypoxia-inducible factor-1α (HIF-1α) expression and promote the activation of hepatic stellate cells (HSCs), leading to liver fibrosis. Currently, effective treatment for liver fibrosis is extremely lacking. Herein, a safe and effective method is established to downregulate the expression of HIF-1α in HSCs via targeted delivery of VA-PEG-modified CNs-based nanosheets-encapsulated (VA-PEG-CN@GQDs) HIF-1α small interfering RNA (HIF-1α-siRNA).

Defect-rich MoS/NiS nanosheets loaded on SiNWs for efficient and stable photoelectrochemical hydrogen production.

Photoelectrochemical (PEC) reaction with efficient, stable, and cost-effective photocathodes using non-precious metals will be one of the most environmentally friendly technologies for hydrogen (H) generation under the worldwide pressure for carbon neutrality. Herein, a new 3-dimentional (3D) SiNWs@MoS/NiS photocathode was designed and synthesized. Defect-rich MoS/NiS nanosheets on silicon nanowires (SiNWs) provide more active sites to promote charge transfer and photo-generated electron-hole separation.

CuCo and sulfur doped carbon nitride composite as an effective Fenton-like catalyst in a wide pH range.

The heterogeneous Fenton-like reaction, as an advanced oxidation process, is widely recognized attributed to its recyclability, wide pH response range, easy solid-liquid separation, and non-production of iron sludge. Recently, the bimetallic catalysts have attracted intense attention due to their high catalytic performance and excellent stability over a wide pH range. In this article, CuCo/SCN bimetallic catalyst was prepared by pyrolysis method with sulfur doped carbon nitride (SCN) as the carrier.

Classification and research progress of implant surface antimicrobial techniques.

Due to the good biocompatibility and ideal mechanical property, titanium implants have been widely used in dental clinic and orthopedic surgery. However, bacteria induced infection can cause per-implant inflammation and decrease the success rate of implant surgery. Therefore, developing antimicrobial techniques is essential to successful application of titanium implants.

Direct Z-scheme SiNWs@CoO photocathode with a cocatalyst of sludge-derived carbon quantum dots for efficient photoelectrochemical hydrogen production.

Solar driven photoelectrochemical (PEC) hydrogen production has attracted considerable attention, but the design of highly efficient, robust and low-cost photocathode still remains a significant challenge. Herein, we report a novel SiNWs@CoOZ-scheme heterojunction photocathode with carbon quantum dots eco-friendly derived from sludge (SCQDs) as the co-catalyst. The photocathode not only leads to effective separation of electron-hole pair, lower transmission resistance, and longer lifetime of charge carriers, but also elevates the stability by preventing direct contact between the SiNWs and the electrolyte as well as the self-oxidation.

A 12-Year-Old Girl Presenting With Recurrent Dyspnea and Pulmonary Ground-Glass Opacities.

A 12-year-old girl presented with shortness of breath with exercise for 2 weeks. Her oxygen saturation was 85% during exercise. Birth and family histories were unremarkable.

Effects of several tea extracts on nonalcoholic fatty liver disease in mice fed with a high-fat diet.

Nonalcoholic fatty liver disease (NAFLD) is considered as a severe threat to human health. It has been reported that tea has abundant bioactive compounds and beneficial effects. In our study, the effects of 12 tea extracts on NAFLD were assessed and compared at the dose of 200 mg/kg body weight in mice fed with a high-fat diet (HFD) for 15 weeks.

Clinical features, treatment, and survival outcome of primary pulmonary NUT midline carcinoma.

Objective: NUT midline carcinoma (NMC), a rare type of squamous cell carcinoma, is genetically characterised by NUT midline carcinoma family member 1 (NUTM1) gene rearrangement. NMC can arise from the lungs; however, there is no standard for the management of primary pulmonary NMC. This study aimed to confirm the clinical features and report the treatments, especially with immune checkpoint inhibitors (ICIs), and outcomes of patients with primary pulmonary NMC.

Case report: dermatomyositis associated with lung cancer with heterogeneous morphology.

Dermatomyositis (DM) complicated with non-small cell lung cancer (NSCLC) is not rare, and could rapidly develop into severe lung cancer [performance-status score (PS) between 2 and 4]. Moreover, tumor has remarkable heterogeneity, and it is not possible to properly target treatments in cases of relapse without knowing pathological diagnosis. We retrospectively analyzed the diagnosis and treatment of a patient with DM complicated with NSCLC, which developed into severe lung cancer with heterogeneity of the tumor during chemotherapy.

The enhancement of synthesized wastewater on non-uniform electrokinetic remediation of a Cd-spiked natural clayey soil.

It is usually very difficult to achieve satisfactory extraction efficiencies in electrokinetic remediation of heavy metal-contaminated soils of high acid/base buffer capacity. Enhancement agent is often required. In this study, synthesized citric acid industrial wastewater (CAIW) is used as the enhancement agent to remediate cadmium-spiked natural clayey soil from Shanghai, China.

[Enhanced Electrokinetic Remediation of Heavy Metals Contaminated Soils by Stainless Steel Electrodes as well as the Phenomenon and Mechanism of Electrode Corrosion and Crystallization].

Electrode corrosion and salt crystallization are important challenges that restrict the engineering application of electrokinetic technology. In the present study, using stainless steel as an electrode, and deionized water (DW), citric acid (CA) and polyaspartic acid (PASP) as electrolytes, Pb/Cu-contaminated soil was remediated by electrokinetic. All of the EK experiments were conducted in a 2 L soil cell reactor with a moisture level of about 35% blended with 1000 mg·g of Pb and 778 mg·g of Cu under a constant voltage gradient (1 V·cm, 2 V·cm) for 150 h.

A case report of acute fibrinous and organizing pneumonia with pneumothorax and avian exposure history.

Acute fibrinous and organizing pneumonia (AFOP) is an uncommon variant of acute lung injury. Here, we report a patient with AFOP and a previously unreported condition, pneumothorax. After our experience with this case, we suggest that exposure to birds may be associated with AFOP; pneumothorax can develop in patients with AFOP; and glucocorticoids are very effective for treating AFOP.

Validation of human small airway measurements using endobronchial optical coherence tomography.

Background: Small airway remodeling is the cardinal feature underlying chronic airway diseases. There is no modality which identifies small airway pathological changes, which is crucial for early diagnosis, efficacy and prognostic assessment.

Objective: To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo.

Sputum matrix metalloproteinase-8 and -9 and tissue inhibitor of metalloproteinase-1 in bronchiectasis: clinical correlates and prognostic implications.

Background And Objective: The triplet of airway infection, inflammation and bronchial wall destruction associated with excessive matrix metalloproteinases (MMP) release and imbalance of tissue inhibitor metalloproteinase-1 (TIMP-1) is implicated in bronchiectasis. We sought to determine the associations between sputum MMP (MMP-8, MMP-9) and TIMP-1 and the severity of bronchiectasis; the utility of MMP in predicting risks of future bronchiectasis exacerbations (BE); and the changes in MMP levels during BE.

Methods: We recruited 102 patients with stable bronchiectasis and 22 healthy subjects.

A Highly Selective and Sensitive Turn-On Fluorescent Chemosensor Based on Rhodamine 6G for Iron(III).

Recently, more and more rhodamine derivatives have been used as fluorophores to construct sensors due to their excellent spectroscopic properties. A rhodamine-based fluorescent and colorimetric Fe(3+) chemosensor 3',6'-bis(ethylamino)-2-acetoxyl-2',7'-dimethyl-spiro[1H-isoindole-1,9'-[9H]xanthen]-3(2H)-one (RAE) was designed and synthesized. Upon the addition of Fe(3+), the dramatic enhancement of both fluorescence and absorbance intensity, as well as the color change of the solution, could be observed.

[Bronchoesophageal fistula secondary to mediastinal lymph node tuberculosis: a case report and review of the literature].

Objective: To analyze the clinical features of 1 case of bronchoesophageal fistula (BEF) secondary to mediastinal lymph node tuberculosis.

Methods: The clinical, auxiliary examinational and pathological data of 1 case with BEF were presented, and the literatures were reviewed.

Results: The patient was a 19 year old female, who was admitted to hospital because of fever and cough associated with liquid intake.

A review on techniques to enhance electrochemical remediation of contaminated soils.

Electrochemical remediation is a promising remediation technology for soils contaminated with inorganic, organic, and mixed contaminants. A direct-current electric field is imposed on the contaminated soil to extract the contaminants by the combined mechanisms of electroosmosis, electromigration, and/or electrophoresis. The technology is particularly effective in fine-grained soils of low hydraulic conductivity and large specific surface area.

Desorption of cadmium from a natural Shanghai clay using citric acid industrial wastewater.

The sorption/desorption characteristics of heavy metals onto/from soil particle surfaces are the primary factors controlling the success of the remediation of heavy-metal contaminated soils. These characteristics are pH-dependent, chemical-specific, and reversible; and can be modified by enhancement agents such as chelates and surfactants. In this study, batch experiments were conducted to evaluate the feasibility of using citric acid industrial wastewater (CAIW) to desorb cadmium from a natural clay from Shanghai, China at different soil mixture pHs.