Publications by authors named "Ying Wo"
Aim: To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China.
Materials & Methods: A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract infections. WUPyV was detected using real-time PCR and complete genome was sequenced for randomly selected positive nasopharyngeal aspirate.
Background: Adenovirus is a frequent cause of mild self-limiting upper respiratory tract infection, gastroenteritis, and conjunctivitis. Severe or fatal infection mostly occurs in newborn, elderly or immunocompromised persons.
Methods: Fatal adenovirus pneumonia in three immunocompetent adults was identified.
Article Synopsis
- - The study examined the epidemiology of Saffold cardiovirus (SAFV) in Chinese pediatric patients with a focus on three groups: those with respiratory infections, diarrhea, and hand, foot, and mouth disease (HFMD), between 2009 and 2012.
- - Out of 6052 patients, 115 were confirmed SAFV-positive, with a higher detection rate in the HFMD group, and severe clinical outcomes, including nervous system issues, were more prevalent among these patients.
- - Four SAFV genotypes were identified, and testing revealed distinct geographical clustering, suggesting a link between SAFV infection and HFMD while indicating a broader range of clinical manifestations.
Human adenoviruses (HAdV) of species B, C, and E (HAdV-B, -C, -E) are frequent causative agents of acute respiratory infections worldwide. No specific analysis has been done on the epidemiological and clinical features of HAdV in pediatric pneumonia in China. Nasopharyngeal aspirates were collected from hospitalized children with pneumonia from June 2009 to May 2014.
View Article and Find Full Text PDFHuman rhinovirus-C (HRV-C) has been increasingly detected in patients with acute respiratory diseases (ARDs). Prolonged surveillance was performed on children with ARD to investigate the molecular epidemiology and clinical characteristics of HRV in Chongqing, China. Nasopharyngeal aspirates (NPA) were collected from hospitalized children with ARD during 2009-2012.
View Article and Find Full Text PDFUnlabelled: Over the course of two waves of infection, H7N9 avian influenza A virus has caused 436 human infections and claimed 170 lives in China as of July 2014. To investigate the prevalence and genetic diversity of H7N9, we surveyed avian influenza viruses in poultry in Jiangsu province within the outbreak epicenter. We found frequent occurrence of H7N9/H9N2 coinfection in chickens.
View Article and Find Full Text PDFBackground: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus (SFTSV) in China. Humans of all ages living in endemic areas have high risk of acquiring SFTS. Most clinical data so far have been from adults and no clinical study was available from children yet.
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- Enterovirus 118 (EV-118) was found in two 5-month-old boys with pneumonia in China, showing genetic similarities to an Israeli strain rather than a Peruvian one.
- The complete genome of EV-118 is 7,360 nucleotides long and includes a single open reading frame that encodes a 2,206-amino-acid polyprotein.
- This detection marks the first identification of EV-118 genome sequences in China, highlighting genetic differences from strains found in Peru.
Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009-2012.
Influenza Other Respir Viruses
May 2014
Background: Human adenovirus 55 (HAdV-55) has caused recent outbreaks of acute respiratory disease (ARD) among adults and military trainees. The active surveillance for HAdV infections was sparse in China, and current knowledge on the HAdV-type distributions and its molecular evolution is lacking.
Objectives: To acquire better understanding on the prevalence and molecular evolution of HAdV-55 strains in China, for an informed strategy for disease control and prevention.
Article Synopsis
- The study aimed to assess the prevalence of human enteroviruses (HEVs) in healthy children, their parents, and children suffering from hand, foot, and mouth disease (HFMD) through a case-control approach involving throat samples.
- Results showed a significant difference in HEV positive rates, with HFMD patients having much higher rates of enterovirus types EV71, CVA16, and CVA10 compared to healthy controls, indicating a strong association between these viruses and HFMD severity.
- Additionally, analysis revealed that children are more likely to test positive for HEV than adults, highlighting the need for targeted attention on HFMD prevention and control measures.
Article Synopsis
- Human enterovirus 68 (HEV-68) is linked to respiratory issues in children, and a study in mainland China from 2009 to 2012 found HEV-68 in a small percentage of tested samples.
- Out of 1,565 child samples, 41 tested positive for HEV, with 7 specifically identified as HEV-68, while 2 HEV-68 samples were also found in adult cases.
- The study suggests that HEV-68 may be a major contributor to respiratory infections in kids and highlights the need for more research to understand the virus's varying impact on health, ranging from mild to severe symptoms.
Coxsackieviruses A10 (CV-A10) and A6 (CV-A6) have been associated with increasingly occurred sporadic hand-foot-mouth disease (HFMD) cases and outbreak events globally. However, our understanding of epidemiological and genetic characteristics of these new agents remains far from complete. This study was to explore the circulation of CV-A10 and CV-A6 in HFMD and their genetic characteristics in China.
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