Child psychological maltreatment, depression, psychological inflexibility and difficulty in identifying feelings, a moderated mediation model.

Child psychological maltreatment has a strong relationship with college students' depression. However, the potential mediating and moderating variables between the two need further exploration. This study collected subjective data of college students from two universities in China through a cross-sectional survey, including variables such as child psychological maltreatment, psychological inflexibility, difficulty in identifying feelings, and depression.

Therapeutic applications of drug coated balloons in symptomatic intracranial arterial stenosis: systematic review and quantitative meta-analysis.

Background: Intracranial atherosclerotic stenosis (ICAS) represents a major cause of ischemic stroke, with endovascular treatments, such as stenting, facing challenges such as restenosis and complications. Drug coated balloons (DCBs) provide a promising alternative by delivering targeted drug without permanent implants. This review systematically evaluates the efficacy and safety of DCBs for symptomatic ICAS, providing evidence based insights to guide clinical practice.

Engineering Iridium Nanoclusters for Boosting Ferroptotic Cell Death by Regulating GPX4 and p53 Functions.

Emerging evidence indicates that modulating glutathione peroxidase 4 (GPX4) to induce ferroptosis is a promising strategy for tumor treatment. However, most of the GPX4 small molecule inhibitors face limitations due to their poor delivery efficacy and low specificity of ferroptosis activation. Herein, a ferroptosis-inducing nanomedicine is developed that integrates nutlin-3 with iridium oxide nanoclusters (NUT-IrO NCs) for enhanced ferroptosis-driven multimodal therapeutic efficacy in colorectal cancer (CRC).

Microstructure and Properties of AlCrCoFeNi High-Entropy Alloys Prepared by Spark Plasma Sintering.

CoCrFeNi high-entropy alloys represent a novel structural material with considerable application potential in a variety of fields, including aerospace, automobiles, ships, machining, energy, soft magnetic materials, and hydrogen storage materials. The present study investigates the impact of the Al element on the structure and properties of the alloy. The preparation of the AlCrCoFeNi ( = 0.

First-principles calculation of the stopping power of protons in hexagonal boron nitride with different stacking sequences.

This study employs the real-time time-dependent density functional theory method to conduct an in-depth investigation of the energy dissipation mechanism of proton in hexagonal boron nitride (h-BN) materials. By calculating the stopping power to quantify the energy dissipation of proton, we find that the energy dissipation in h-BN is primarily dependent on electron excitation, with relatively minor nuclear energy loss. Furthermore, we analyze the micro-dynamic behavior of radiation particles in detail by tracking the forces exerted on proton and the charge transfer process.

Optical biosensing of monkeypox virus using novel recombinant silica-binding proteins for site-directed antibody immobilization.

The efficient immobilization of capture antibodies is crucial for timely pathogen detection during global pandemic outbreaks. Therefore, we proposed a silica-binding protein featuring core functional domains (cSP). It comprises a peptide with a silica-binding tag designed to adhere to silica surfaces and tandem protein G fragments (2C2) for effective antibody capture.

Non-Volatile Multifunctional Dipole Molecules Enable 19.2% Efficiency for Printable Mesoscopic Perovskite Solar Cells.

Dipole molecules (DMs) show great potential in defect passivation for printable mesoscopic perovskite solar cells (p-MPSCs), although the crystallization process of p-MPSCs is more intricate and challenging than planar perovskite solar cells. In this work, a series of non-volatile multifunctional DMs are employed as additives to enhance the crystallization of perovskites and improve both the power conversion efficiency (PCE) and stability of the devices. This enhancement is achieved by regulating the side groups of benzoic acid molecules with the electron-donating groups such as guanidine (─NH─C(═NH)─NH), amino (─NH) and formamidine (─C(═NH)─NH).

Ultrasound localization microscopy in the diagnosis of breast tumors and prediction of relevant histologic biomarkers associated with prognosis in humans: the protocol for a prospective, multicenter study.

Background: Benign and malignant breast tumors differ in their microvasculature morphology and distribution. Histologic biomarkers of malignant breast tumors are also correlated with the microvasculature. There is a lack of imaging technology for evaluating the microvasculature.

Targeting the tumor microenvironment with mesenchymal stem cells based delivery approach for efficient delivery of anticancer agents: An updated review.

Drug delivery to cancer cells continues to present a major therapeutic challenge. Mesenchymal stem cells (MSCs) possess an intrinsic ability to migrate specifically to tumor tissues, making them promising candidates for targeted drug delivery. Evidence from preclinical studies indicates that MSCs loaded with therapeutic anti-cancer agents exhibit considerable anti-tumor activity.

Cilia-Mimic Locomotion of Magnetic Colloidal Collectives Enhanced by Low-Intensity Ultrasound for Thrombolytic Drug Penetration.

Rapid thrombolysis is very important to reduce complications caused by vascular blockage. A promising approach for improving thrombolysis efficiency is utilizing the permanent magnetically actuated locomotion of nanorobots. However, the thrombolytic drug transportation efficiency is challenged by in-plane rotating locomotion and the insufficient drug penetration limits further improvement of thrombolysis.

Novel Design of Eco-Friendly High-Performance Thermoplastic Elastomer Based on Polyurethane and Ground Tire Rubber toward Upcycling of Waste Tires.

Waste rubber tires are an area of global concern in relation to reducing the consumption of petrochemical products and environmental pollution. Herein, eco-friendly high-performance thermoplastic polyurethane (PU) elastomers were successfully in-situ synthesized through the incorporation of ground tire rubber (GTR). The excellent wet-skid resistance of PU/GTR elastomer was achieved by using mixed polycaprolactone polyols with Mn = 1000 g/mol (PCL-1K) and PCL-2K as soft segments.