Research progress on the bioactivity of platycodin D from Platycodon grandifloras.

Platycodon grandiflorus, in the family Platycodonaceae, has been traditionally utilized in China to treat sore throats, hoarseness, and coughs with phlegm. As a medicinal and food plant, P. grandiflorus has a long history of use.

AIDS-Associated Infection with Thoracic Spinal Cord Involvement Leading to Paraplegia: A Case Report and Literature Review.

Background: is a common opportunistic infection in patients with acquired immune deficiency syndrome (AIDS) in South China. Spinal cord abscesses caused by are exceptionally rare and present with non-specific symptoms, which may result in delayed diagnosis and heightened adverse prognoses.

Case Presentation: We report a case of a spinal cord abscess in a 30-year-old patient with AIDS that was caused by infection.

Transcriptome analysis of the hypothalamus and testes in Brandt's Vole: new insights into mechanisms of photoperiodic plasticity in postnatal testicular development.

Postnatal gonadal development is regulated by photoperiod via the hypothalamus, especially in seasonal breeding small rodents. However, the precise molecular mechanisms remain unclear. In this study, we conducted a comparative analysis of the transcriptomes of the hypothalamus and testes in 10-week-old male Brandt's voles born under long (LP, 16L:8D) and short photoperiod (SP, 8L:16D) conditions.

Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis.

Background And Aims: Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these associations with GERD.

Ultra-sparse-view Cone-beam CT Reconstruction Based Strictly-structure-preserved Deep Neural Network in Image-guided Radiation Therapy.

Radiation therapy is regarded as the mainstay treatment for cancer in clinic. Kilovoltage cone-beam CT (CBCT) images have been acquired for most treatment sites as the clinical routine for image-guided radiation therapy (IGRT). However, repeated CBCT scanning brings extra irradiation dose to the patients and decreases clinical efficiency.

Continuous glucose monitoring (CGM) system based on protein hydrogel anti-biofouling coating for long-term accurate and point-of-care glucose monitoring.

Continuous Glucose Monitoring (CGM) device was a kind of based on flexible electrode interstitial fluid (ISF) implantation that used electrochemical methods to track blood glucose fluctuations, which made continuous real-time glucose monitoring and personalized blood glucose management increasingly possible. However, when the electrode of CGM in the body fluid environment for a long time, the occurrence of bio-fouling will lead to CGM signal deviation, service life reduction, accuracy decline and other problems. Therefore, in this paper, we constructed a new strategy that provided a well-defined, anti-biofilm coating based and integrated smartphone-controlled wearable microneedle system CGM (acCGM) that can significantly improve accuracy during use and potentially extend service life.

Divergent Photoperiodic Responses in Hypothalamic Expression and Gonadal Activity Between Offspring and Paternal Brandt's Voles.

The postnatal development of gonadal glands in seasonal breeders, particularly small rodent species, is influenced by photoperiodic patterns. However, little research has been conducted on the effects of pattern similarity and age differentiation especially in molecular features. This study compares the postnatal development of gonadal glands and the expression of hypothalamic genes related to reproductive regulation in male offspring of Brandt's voles () born under three types of changing photoperiodic patterns: increasing long photoperiod (ILP, 12 h + 3 min/day), natural increasing long photoperiods (NLPs), and decreasing short photoperiods (DSPs, 12 h - 3 min/day), as well as in their paternal voles exposed to these patterns at the same period.

Androgen Receptor Expression Governs the Seasonal Inhibition of Testicular Development and Subsequent Recovery in .

Commonly in seasonal breeding animals, testicular development is inhibited prior to Sertoli cell maturation when environmental conditions become unfavorable, with recovery occurring once conditions improve. However, the precise molecular mechanisms governing this process remain unclear. We investigated the role of androgen receptor (AR) in the seasonal regulation of testicular development in a wild population of , a subspecies of brown rats in Northeast China residing in high-latitude regions, known for its seasonal reproductive patterns.

Dextran from human feces-derived Weissella cibaria facilitates intestinal mucosal barrier function by modulating gut bacteria and propionate levels.

The disruption of the intestinal mucosal barrier is strongly associated with the onset of various diseases, including inflammatory bowel disease. Exopolysaccharides (EPS) support the functionality of the intestinal barrier. Weissella Cibaria (W.

Role of the Transcription Factor FoxO in Type 2 Diabetes and Its Complications.

FoxO proteins represent a subfamily of the forkhead box family (Fox) superfamily of proteins. It is involved in cell proliferation, differentiation, oxidative stress, apoptosis as well as tumors and metabolic disorders by regulating cellular functions. This paper aims to summarize the role of the transcription factor FoxO in type 2 diabetes and its complications, which may add to the potential of FoxO as a therapeutic target for future research.

Ultralight, Elastic, Thermally Insulating, and High-Temperature Resistant AlO-SiO-BO Nanofibrous Aerogels Prepared via the Direct Foaming Method.

Ceramic nanofibrous aerogels exhibit ultralow density and thermal conductivity, which make them ideal candidates for thermal protection in extreme environments. However, the current limitations in pore-forming techniques hinder their further advancement. In this study, ultralight, highly elastic, and high-temperature-resistant ceramic nanofibrous aerogels were successfully prepared through the direct foaming method using flexible AlO-SiO-BO nanofibers as raw materials and Tween 80 as the foaming agent.

Risk Prediction of Myelosuppression Following First-line Chemotherapy in Colorectal Cancer.

Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with over 1.9 million new cases and 904,000 deaths in 2022. Chemotherapy is a primary treatment for CRC but often leads to myelosuppression, significantly affecting treatment efficacy and patient outcomes.

Isoliquiritigenin Protects Against Diabetic Nephropathy in db/db Mice by Inhibiting Advanced Glycation End Product-Receptor for Advanced Glycation End Product Axis.

Diabetes nephropathy (DN) is a severe diabetic chronic microvascular complication and the major cause of end-stage renal disease (ESRD). Our study aimed to investigate the effects of isoliquiritigenin (ISL) a natural flavonoid compound on DN and to explore the underlying mechanisms. The db/db mice were received intragastric treatments of ISL (5, 10, or 20 mg/kg), vehicle or positive drug metformin (300 mg/kg) once a day for 12 weeks, and the db/m mice treated with vehicle were used as controls.

Recent developments and challenges of molecular design in linear cyanido-bridged multimetallic complexes.

Cyanido-bridged multimetallic complexes have been extensively studied for their potential applications in molecular electronics and spintronics. The design of these complexes involves the strategic placement of metal centers and the use of cyanide bridges to facilitate electron transfer between metal ions. The challenges in this field include the precise control of the electronic states and the stability of the complexes under various conditions.

An Optimized Method for Batch Recovery Based on Erasure Coding in Heterogeneous Network.

With the rapid development of IoT technology, sensors are widely used for monitoring environmental parameters. The data collected by sensors needs to be stored, and distributed storage systems provide an excellent platform to handle this vast amount of data. To enhance data reliability and reduce storage costs, erasure coding technology can be employed within distributed storage systems.

Surfactant-free W/O high internal phase emulsions co-stabilized by beeswax and phytosterol crystal scaffold: A promising fat mimetic with enhanced mechanical and mouthfeel properties.

Water-in-oil high internal phase emulsions (W/O-HIPEs) typically rely on large amounts of surfactants to disperse water droplets and usually use crystalline saturated triacylglycerides (TAGs) to enhance processing properties. However, these practices conflict with consumer demands for 'natural' ingredients. This study seeks to develop novel crystal fractions similar to saturated TAGs for the preparation of W/O-HIPEs as low-calorie fat mimetics, focusing on their mechanical and mouthfeel properties, which have received little attention thus far.

Tunable Memory Performances of Hyperbranched Polyimides Functionalized with Metal-Porphyrins.

With the rapid advancement of information technology, the need to achieve ultra-high-density data storage has become a pressing necessity. This study synthesized three hyperbranched polyimides (HBPI-TAPP, HBPI-(Zn)TAPP, and HBPI-(Cu)TAPP) by polymerizing 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TAPP), which features a cavity for metal ion coordination, with 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), to systematically investigate the effect of metal ion species on storage performance. According to the results, memory devices based on HBPI-(Zn)TAPP exhibit volatile SRAM (static random-access memory) characteristics, whereas devices employing HBPI-TAPP and HBPI-(Cu)TAPP demonstrate non-volatile WORM (write-once, read-many) characteristics.

The total extract of Abelmoschus manihot (L.) medic flowers (TEA) mediated Nrf2-TFAM signalling to regulate mitochondrial antioxidant mechanism.

Skin, as the first line of defence of the human body, is exposed to dangers such as overheating substances, ultraviolet rays, and environmental pollutants, and the incidence of skin diseases is increasing annually. Oxidative stress plays a dominant role in most skin diseases. Abelmoschus manihot (L.

Systemic Sodium Iodate Injection as a Model for Expanding Geographic Atrophy.

Purpose: Geographic atrophy (GA), an advanced form of dry age-related macular degeneration (AMD), has limited treatment options. This study introduces a novel mouse model featuring an expanding GA patch that can be used to test mechanisms and therapeutics.

Methods: C57Bl/6J male mice (n = 96) aged 9-10 weeks received an intraperitoneal (IP) injection of 20 mg/kg sodium iodate (NaIO3).

Association of Metformin use with risk of dementia in patients with type 2 diabetes: A systematic review and meta-analysis.

Aim: There is ongoing debate concerning the association of metformin with the risk of dementia in type 2 diabetes mellitus (T2DM). This study was conducted to evaluate the impact of metformin therapy on dementia in patients with T2DM.

Materials And Methods: PubMed, Embase, Cochrane Library, Web of Science and the ClinicalTrials.

Erratum: Regulation of ezrin tension by S-nitrosylation mediates non-small cell lung cancer invasion and metastasis: Erratum.

[This corrects the article DOI: 10.7150/thno.32479.

Global, regional, and national burden of acute lymphoblastic leukemia in children: Epidemiological trends analysis from 1990 to 2021.

Children are the main susceptible group to acute lymphoblastic leukemia (ALL), and the lack of sufficient data has impeded a comprehensive understanding of its global impact. This study analyzed the annual numbers and rates of incidence, deaths, and disability-adjusted life years (DALYs) of childhood ALL from 1990 to 2021, disaggregated by age group, gender, and socio-demographic index (SDI) at the global, regional, and national levels, based on the 2021 Global Burden of Disease (GBD) database. Although global deaths and DALYs rates for childhood ALL showed declining trends, the incidence rate fluctuated.

The Value of LC-MS/MS in Apparent Bilateral Aldosterone Suppression in Adrenal Venous Sampling for Primary Aldosteronism.

Context: Adrenal venous sampling (AVS) is recommended for subtyping primary aldosteronism (PA), however, it is unreliable when apparent bilateral aldosterone suppression (ABAS) occurs, defined as aldosterone/cortisol ratio in the adrenal vein being bilaterally lower than that in the inferior vena cava. The value of Liquid chromatography-tandem mass spectrometry (LC-MS/MS) in PA subtyping when ABAS occurs is unclear.

Objective: To determine whether LC-MS/MS can reduce the occurrence of ABAS and misdiagnosis of PA subtyping.