Can structural or functional changes following traumatic brain injury in the rat predict epileptic outcome?

Purpose: Posttraumatic epilepsy (PTE) occurs in a proportion of traumatic brain injury (TBI) cases, significantly compounding the disability, and risk of injury and death for sufferers. To date, predictive biomarkers for PTE have not been identified. This study used the lateral fluid percussion injury (LFPI) rat model of TBI to investigate whether structural, functional, and behavioral changes post-TBI relate to the later development of PTE.

Progressive metabolic and structural cerebral perturbations after traumatic brain injury: an in vivo imaging study in the rat.

Unlabelled: Traumatic brain injury (TBI) has a high incidence of long-term neurologic and neuropsychiatric morbidity. Metabolic and structural changes in rat brains were assessed after TBI using serial (18)F-FDG PET and 3-dimensional MRI in vivo.

Methods: Rats underwent lateral fluid percussion injury (FPI; n = 16) or a sham procedure (n = 11).

Progressive brain changes on serial manganese-enhanced MRI following traumatic brain injury in the rat.

Traumatic brain injury (TBI) has a high incidence of long-term morbidity. Manganese-enhanced MRI (MEMRI) provides high contrast structural and functional detail of the brain in-vivo. The study utilized serial MEMRI scanning in the fluid percussion injury (FPI) rat's model to assess long-term changes in the brain following TBI.

MRI-based large deformation high dimensional mapping of the hippocampus in rats: development and validation of the technique.

Purpose: To report the detection of structural and functional biological changes in living animals using small animal in vivo MRI that complements traditional ex vivo histological techniques. We report the development and validation of the application of large deformation high dimensional mapping (HDM-LD) segmentation for the hippocampus in the rat.

Materials And Methods: High resolution volumetric T2 weighted MRI images were acquired at 4.