Role of clinical biomarkers in predicting the effectiveness of omalizumab.

Objective: To explore whether baseline clinical biomarkers and characteristics can be used to predict the responsiveness of omalizumab.

Methods: We retrospectively analyzed a cohort of patients with severe asthma who received omalizumab treatment and collected their baseline data and relevant laboratory examination results along with case records of omalizumab treatment responsiveness after 16 weeks. We compared the differences in variables between the group of patients that responded to omalizumab therapy and the non-responder group, and then performed univariate and multivariate logistic regression.

Artesunate inhibits airway remodeling in asthma the MAPK signaling pathway.

Artesunate (ART), is a semi-synthetic water-soluble artemisinin derivative extracted from the plant , which is often used to treating malaria. and studies suggested it may help decrease inflammation and attenuate airway remodeling in asthma. However, its underlying mechanism of action is not elucidated yet.

Usage, acceptability, and preliminary effectiveness of an mHealth-based integrated modality for smoking cessation interventions in Western China.

Introduction: Many smokers have not accessed professional smoking cessation assistance due to limited smoking cessation services. We developed a novel mHealth-based integrated modality for smoking cessation (WeChat + Quitline modality, WQ modality) and applied it to a large public welfare project (China Western-QUIT Program) in western China. This study evaluated the usage, acceptability, and preliminary effectiveness of the WQ modality in the population of western China.

A Longitudinal Study of Trajectories and Factors Influencing Patient-Reported Outcomes in Chronic Obstructive Pulmonary Disease.

Purpose: To explore the trajectory of patient-reported outcomes and the factors influencing them in patients with COPD.

Patients And Methods: The study population, 236 patients with stable COPD who attended the outpatient clinic of the Department of Respiratory and Critical Care Medicine in a tertiary care hospital in Nanning City between October 2020 and November 2021, answered the modified patient-reported outcome scale for COPD (mCOPD-PRO). Patient-reported outcomes were investigated at the time of the patient's outpatient visit (T1), 1 month after the visit (T2), 3 months after the visit (T3), and 6 months after the visit (T4).

Health Priorities in Chronic Obstructive Pulmonary Disease Patients with Multimorbidity: A Qualitative Study.

Purpose: To explore the health priorities of patients with multimorbidity in COPD and the factors as to why their condition is prioritized.

Methods: This qualitative study was conducted from February to April 2022 at a hospital in China. A specially selected sample of 18 patients completed a general information sheet and face-to-face interviews.

Diagnostic and Staging Value of Serum Angiotensin-Converting Enzyme in Sarcoidosis.

Objective: To investigate the diagnostic and staging value of serum angiotensin-converting enzyme (sACE) in sarcoidosis.

Methods: Patients with suspected sarcoidosis treated in the Department of Pulmonary and Critical Care Medicine of the China-Japan Friendship Hospital from 2010 to 2020 were included. The data of sACE, erythrocyte sedimentation rate (ESR), complete blood count (CBC), lung function, bronchoalveolar lavage, and biopsy were collected.

Weakened Cd toxicity to fungi under coexistence of Pb in solution.

The coexistence of heavy metals in aquatic systems causes complex toxicity in microorganisms. In this study, we explored the influences of Pb addition on Cd toxicity in Rhodotorula mucilaginosa (Rho). Cd toxicity alone was tested with up to 200 mg/L Cd to induce stress.

Puzzling onsets of pneumonia sequentially after each session of bronchial thermoplasty: a case report.

Background: Bronchial thermoplasty (BT) is a novel bronchoscopic intervention for severe persistent asthma. An increase in transient respiratory adverse events associated with BT were noted over the treatment periods, however, these events appear sporadic and should not always recur in a single individual and BT-related pneumonia has rarely been reported.

Case Presentation: We present a case of uncontrolled severe asthma who developed puzzling pneumonia sequentially after each session of BT procedures.

Application of Pb(II) to probe the physiological responses of fungal intracellular vesicles.

Vesicles (Ves) within fungal cells are the critical linkage between intracellular and extracellular systems. This study explored the application of Pb to probe the physiology of intracellular Ves in Rhodotorula mucilaginosa (Rho). At low Pb levels (0-500 mg/L), there was no evident change in the content of extracellular polymeric substances (EPS) or microbial activity.

A traditional Chinese patent medicine-Suhuang zhike capsule for cough variant asthma in adults: A protocol of systematic review and meta-analysis of randomized controlled trials.

Background: Many people with cough variant asthma use Traditional Chinese Patent Medicine-Suhuang anti-tussive capsule to help reduce symptoms. However there is no systematic reviews had promising its efficacy and safety for cough variant asthma.

Methods: Four English databases (PubMed, Web of science, EMBASE, and Springer Cochrane Library) and 4 Chinese databases (Wanfang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) were researched for the randomized controlled trials of Suhuang anti-tussive capsule for cough variant asthma.

Contrasting the Pb (II) and Cd (II) tolerance of Enterobacter sp. via its cellular stress responses.

Successful application of microorganisms to heavy metal remediation depends on their resistance to toxic metals. This study contrasted the differences of tolerant mechanisms between Pb and Cd in Enterobacter sp. Microbial respiration and production of formic acid showed that Enterobacter sp.

Chinese consensus statement on standard procedure and perioperative management of bronchial thermoplasty.

Bronchial thermoplasty (BT) is a non-pharmacologic therapy for severe asthma. The proper procedure and perioperative management are very important for the effectiveness and safety of BT. China Asthma Alliance assembled a group of experts in asthma and BT to review the literature, drew on their own experiences, discussed, and then finalized by consensus to establish this standard practice guideline.

[Comparison of the Effectiveness of Different Supraglottic Ventilation Methods during Bronchial Thermoplasty].

Objective: To compare the effectiveness of high-frequency jet ventilation via Wei jet nasal airway and controlled ventilation with improved laryngeal mask airway during bronchial thermoplasty.

Methods: Twenty-eight patients undergoing bronchial thermoplasty were equally divided into two groups: group A (high-frequency jet ventilation through Wei jet nasal airway) and group B (controlled ventilation with improved laryngeal mask airway). Pulse oxygenation,heart rate,and mean arterial blood pressure were recorded after entering the operating room (T0), 1 minute after administration/induction (T1), bronchoscope inserting (T2), 15 minutes (T3)/30 minutes (T4)/45 minutes (T5) after ventilation,at the end of the operation (T6), and at the recovery of patients' consciousness (T7).

[Effectiveness and safety of bronchial thermoplasty in patients with severe asthma].

Objective: To assess the effectiveness and safety of bronchial thermoplasty (BT) in patients with severe asthma.

Method: The China-Japan Friendship Hospital recruited 12 patients with severe asthma who were voluntary to take BT treatment from March 2014 to November 2014. The levels of airway inflammation and biological markers (percentage of blood eosinophils, percentage of sputum eosinophils, serum IgE, fractional exhaled nitric oxide) of the patients were examined before the treatment in order to identify the types of airway inflammation.

[Airway inflammatory phenotypes of asthmatic patients].

Objective: To analyze the airway inflammatory phenotypes and clinical features of severe asthma compared to mild-moderate ("common") asthma.

Methods: A total of 946 cases of asthma were retrospectively analyzed in our hospital from January 2013 to December 2014. Sixty-one patients were classified to the severe asthma group, and 885 patients to the common asthma group.

[Values of fractional exhaled nitric oxide in the diagnosis of chronic cough].

Objective: To evaluate the diagnostic value of fractional exhaled nitric oxide (FeNO) in the diagnosis of chronic cough.

Methods: A total of 106 subjects with chronic cough and normal chest radiographs were recruited from October 2009 to September 2010. Based on the management guidelines of the Chinese Respiratory Society for cough, the golden standard methods were used to make the definite diagnosis of chronic cough, including sputum cell counts, pulmonary function tests, bronchial hyperresponsiveness, 24-h esophageal pH monitoring, skin pricking test and serum immunoglobulin E.

[Survey of asthma control and perception in asthmatic outpatients of Beijing urban district].

Objective: To evaluate the status of asthma control and asthma perception in asthmatic outpatients of Beijing urban district.

Methods: A questionnaire survey in a face-to-face setting was conducted among 360 asthmatic out-patients, 144 males and 316 females, aged (48 +/- 15), from June 2007 to December 2007 in 3 class 3 first level general hospitals in 3 Beijing urban districts.

Results: Among 360 asthmatic patients, 325 (90.

[The effect of a vascular endothelial growth factor receptor inhibitor on airway inflammation and airway remodeling in a murine model of asthma].

Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and the effect of a VEGF receptor inhibitor on airway inflammation and remodeling in a murine model of asthma.

Methods: BALB/c mice were randomly divided into three groups: group A (control group, n = 10), group B (asthmatic model group, n = 10) and group C (VEGF receptor inhibitor group, n = 10). The asthmatic model was established by OVA sensitization and challenge.

[Covert infection of severe acute respiratory syndrome in health-care professionals and its relation to the workload and the type of work].

Objective: To study severe acute respiratory syndrome (SARS) covert infection in health-care professionals and its relation to work intensity and type of work.

Methods: Specific antibodies to SARS virus in 1 127 serum specimens from health-care professionals who had a close contact history with patients of SARS and 92 healthy persons were assayed with ELISA.

Results: The health-care professionals consisted of 287 men and 840 women, aged 21 - 55 years (mean 34 +/- 9 years).