The roles of SHANK1 in the development of colon cancer.

SH3 and multiple ankyrin repeat domains protein 1 (SHANK1) belongs to a family of postsynaptic scaffolding proteins. In this study, we found that SHANK1 was abnormally high expressed in colon cancer tissues compared to normal tissues. Colon cancer patients with low SHANK1 expression had better prognosis.

The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells.

Endemic arsenism is widely distributed in the world, which can damage multiple organs, especially in skin and liver. The etiology is clear, but the mechanisms involved remain unknown. Ubiquitin-proteasome pathway (UPP) is the main pathway regulating protein degradation of which proteasome subunit beta type-5(PSMB5) plays a dominant role.

BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling.

Chromatin accessibility is critical for tumor development, whose mechanisms remain unclear. As a crucial regulator for chromatin remodeling, BRD4 promotes tumor progression by regulating multiple genes. As a small-molecule inhibitor of BRD4, JQ1 has potent chemotherapeutic activity against various human cancers.

Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network.

Circular RNAs (circRNAs) are involved in cancer development via inhibition of miRNAs, which are associated with differentiation, proliferation, migration, and carcinogenicity. Curcumin has antioxidant and anti-cancer properties, and it has also been used as a radiosensitizer. In this study, we explored the potential relationships among curcumin, circRNAs, and nasopharyngeal carcinoma (NPC).

Corrigendum: The Fruits of : A Review of a Chinese Food-Medicine.

[This corrects the article DOI: 10.3389/fphar.2019.

Highly Efficient Microcavity Organic Light-Emitting Devices with Narrow-Band Pure UV Emission.

Ultraviolet organic light-emitting devices (UVOLEDs) may combine the tunability properties of organic materials through modifying the molecular structure and the advantages such as large-area, low-cost, and facile to realize high-performance UV sources. In the state-of-the-art UVOLEDs, the external quantum efficiencies (EQE) are more than 3%, but only a few have achieved pure UV emission and could not compromise the durability and irradiance at the same time. Portable compact UV sources with a narrow band made significant achievements in biomedical science and forensic appraisal.

Glaucocalyxin A inhibits hydrogen peroxide-induced oxidative stress and inflammatory response in coronary artery smooth muscle cells.

Atherosclerosis is a complex chronic inflammatory disease that remains one of the leading causes of death and disability worldwide. A previous study reported that glaucocalyxin A (GLA), a natural ent-Kaurane diterpenoid triptolide, exhibits anti-atherosclerotic activity. However, the underlying molecular mechanism has not yet been explored.

Braided composite stent for peripheral vascular applications.

Braided composite stent (BCS), woven with nitinol wires and polyethylene terephthalate (PET) strips, provides a hybrid design of stent. The mechanical performance of this novel stent has not been fully investigated yet. In this work, the influence of five main design factors (number of nitinol wires, braiding angle, diameter of nitinol wire, thickness and stiffness of the PET strip) on the surface coverage, radial strength, and flexibility of the BCS were systematically studied using computational models.

Attention-based fusion network for human eye-fixation prediction in 3D images.

Human eye-fixation prediction in 3D images is important for many 3D applications, such as fine-grained 3D video object segmentation and intelligent bulletproof curtains. While the vast majority of existing 2D-based approaches cannot be applied, the main challenge lies in the inconsistency, or even conflict, between the RGB and depth saliency maps. In this paper, we propose a three-stream architecture to accurately predict human visual attention on 3D images end-to-end.

LncRNA nuclear-enriched abundant transcript 1 regulates hypoxia-evoked apoptosis and autophagy via mediation of microRNA-181b.

Nuclear-enriched abundant transcript 1 (NEAT1), a vital long noncoding RNA (lncRNA), exhibits the functions in disparate cancers. Nevertheless, the influences of NEAT1 in congenital heart disease (CHD) remain unreported. The research delves into whether NEAT1 affects H9c2 cells apoptosis and autophagy under the hypoxia condition.

The Fruits of : A Review of a Chinese Food-Medicine.

(Swingle) C. Jeffrey, a member of the family Cucurbitaceae, is a unique economic and medicinal plant grown in China. For more than 300 years, has been used as a natural sweetener and as a traditional medicine for the treatment of pharyngitis, pharyngeal pain, as well as an anti-tussive remedy in China.

Retrospective Comparison of Endoscopic Full-Thickness Versus Laparoscopic or Surgical Resection of Small (≤ 5 cm) Gastric Gastrointestinal Stromal Tumors.

Aim And Background: The aim of this study was to compare the efficacy and safety between endoscopic full-thickness resection (EFR) and laparoscopic or surgical resection methods for gastric gastrointestinal stromal tumor (GIST) in size of 5.0 cm or less. Gastric GISTs are common, and resection is the most effective treatment.

Curcumin enhances radiosensitization of nasopharyngeal carcinoma by regulating circRNA network.

Circular RNAs (circRNAs) are involved in the regulation of gene expression in different physiological and pathological processes. These macromolecules can act as microRNA (miRNA) sponges and play an important role as gene regulators throughout the circRNA-miRNA pathway. In this study, we established a radioresistance model with the nasopharyngeal carcinoma cell line CNE-2, and then analyzed the differences in the circRNAs between radioresistant and normal nasopharyngeal carcinoma cell lines using a high-throughput microarray.

Effect of anaerobic sludge on the bioelectricity generation enhancement of bufferless single-chamber microbial fuel cells.

Enhancing the self-buffering capacity is critical in the operation of bufferless microbial fuel cells (BLMFCs). Inorganic carbon (IC) is an ideal endogenous buffer, but its spontaneously accumulated concentration is insufficient to adjust anolyte pH. In this study, BLMFCs were operated with anaerobic sludge to enhance IC accumulation and increase anolyte pH.

Postnatal delayed growth impacts cognition but rescues programmed impaired pulmonary vascular development in an IUGR rat model.

Background And Aims: Intrauterine growth restriction (IUGR) is a state of slower fetal growth usually followed by a catch-up growth. Postnatal catch-up growth in IUGR models increases the incidence of pulmonary arterial hypertension in adulthood. Here, we hypothesize that the adverse pulmonary vascular consequences of IUGR may be improved by slowing down postnatal growth velocity.

Succinylation Improves the Thermal Stability of Egg White Proteins.

Succinylation can improve the thermal stability of various proteins. In this study, succinylated egg white protein (SEWP) samples with different succinylation degrees were prepared by adding various succinic anhydride additives to egg white protein (EWP). The thermal stability of SEWP and the conformational structure under various succinylation degrees were investigated.

Treatment of inadvertent subclavian artery cannulation with a percutaneous vascular closure device.

Inadvertent puncture of the subclavian artery is an uncommon but potentially fatal complication of the commonly performed internal jugular vein catheterization. We report a case of accidental subclavian artery catheterization close to the vertebral artery during internal jugular venous cannulation, which was successfully managed in the interventional suite with catheter removal and use of a vascular closure device.

The Structure-Property Correlations in the Isomerism of Au (SR) Nanoclusters by Density Functional Theory Study.

Isomerism of atomically precise noble metal nanoclusters provides an excellent platform to investigate the structure-property correlations of metal nanomaterials. In this study, we performed density functional theory (DFT) and time-dependent (TD-DFT) calculations on two Au (SR) nanoclusters, one with a hexagonal closed packed core (denoted as Au ), and the other one with a face-centered cubic core (denoted as Au ). The structural and electronic analysis on the typical Au-Au and Au-S bond distances, bond orders, composition of the frontier orbitals and the origin of optical absorptions shed light on the inherent correlations between these two clusters.

Intrauterine Growth Restriction Programs Intergenerational Transmission of Pulmonary Arterial Hypertension and Endothelial Dysfunction via Sperm Epigenetic Modifications.

Intrauterine life represents a window of phenotypic plasticity which carries consequences for later health in adulthood as well as health of subsequent generations. Intrauterine growth-restricted fetuses (intrauterine growth restriction [IUGR]) have a higher risk of pulmonary arterial hypertension in adulthood. Endothelial dysfunction, characterized by hyperproliferation, invasive migration, and disordered angiogenesis, is a hallmark of pulmonary arterial hypertension pathogenesis.

Selectivity-tunable amine aerobic oxidation catalysed by metal-free N,O-doped carbons.

Herein, we present a series of N,O-doped mesoporous carbons obtained at different pyrolysis temperatures as the first metal-free catalysts which successfully switch between imine and nitrile products for amine oxidation. Systematic characterization studies and control experiments revealed that the C-O group on the surface could function as a catalytically active site for nitrile synthesis and the N-doping environment was essential.

Functional Identification and Characterization of the Nuclear Egress Complex of a Gammaherpesvirus.

The herpesvirus nuclear egress complex (NEC) is composed of two viral proteins. They play key roles in mediating the translocation of capsids from the nucleus to the cytoplasm by facilitating the budding of capsids into the perinuclear space (PNS). The NEC of alphaherpesvirus can induce the formation of virion-like vesicles from the nuclear membrane in the absence of other viral proteins.

Study on the degradation of accumulated bisphenol S and regeneration of magnetic sludge-derived biochar upon microwave irritation in the presence of hydrogen peroxide for application in integrated process.

Based on the multi-functional magnetic sludge-derived biochar (MSBC), an innovative integrated process-coupling accumulation by adsorbing, degradation by microwave (MW)-induced catalytic oxidation in the presence of HO and the regeneration of adsorbent simultaneously, was proposed. In this study, bisphenol S (4,4'-sulfonyldiphenol) was chosen as the pollutant model, its behaviors and related mechanism of BPS and MSBC in MW + HO system were investigated. The BPS effective degradation on MSBC was proved by decoupling the adsorption and degradation with solvent extraction.

Effect of lncRNA THOR on proliferation and migration of colon cancer cells.

The effect of long non-coding RNA (lncRNA) THOR on proliferation and migration of colon cancer cells was investigated. Lentiviral vector expressing lncRNA THOR shRNA was used to establish colon cancer SW620 lncRNA THOR knockdown cell line (experimental group), and at the same time, a control vector cell line (control group) was established by empty vector virus. Proliferation ability of the two groups was analyzed by CCK8 and EdU methods.

Exposing the Delocalized Cu-S π Bonds on the Au Cu (SPhtBu) Nanocluster and Its Application in Ring-Opening Reactions.

Bimetallic nanomaterials are of major importance in catalysis. A Au-Cu bimetallic nanocluster was synthesized that is effective in catalyzing the epoxide ring-opening reaction. The catalyst was analyzed by SCXRD and ESI-MS and found to be Au Cu (SPhtBu) (Au Cu for short).