Publications by authors named "Ying Lin"

Background: Platostoma palustre is a kind of plant resource with medicinal and food value, which has been differentiated into many different varieties after a long period of breeding. The cultivars of Taiwan(TW) and Pingyuan(PY) are widely grown in Guangdong, but a clear basis for species differentiation has not yet been established, resulting in the mixing of different species which limits their production and application.

Results: Regarding leaf surface morphology, the TW exhibited greater leaf area, non-glandular hairs, and the number of stomata than the PY.

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β-Klotho (KLB), a type I transmembrane protein, serves as an obligate co-receptor determining the tissue-specific actions of endocrine fibroblast growth factors (FGFs). Despite accumulative evidence suggesting the occurrence of N-glycosylation in the KLB protein, the precise N-glycosites, glycoforms, and the impacts of N-glycosylation on the expression and function of the KLB protein remain unexplored. Employing a mass spectrometry-based approach, a total of 12 N-glycosites displaying heterogeneous site occupancy and glycoforms were identified within the extracellular region of the recombinant human KLB protein.

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  • The study aims to analyze the recurrence patterns and survival rates of patients with HER2-low breast cancer compared to those with HER2-0 tumors.
  • Over 2000 patients were evaluated, revealing that HER2-0 patients had a higher risk of visceral recurrence, specifically in the lungs, while HER2-low patients faced increased local recurrence risks but lower risk of contralateral breast cancer.
  • Ultimately, the findings suggest that while recurrence patterns differ between the two groups, HER2-low breast cancer does not appear to represent a separate prognostic category.
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  • Rebaudioside M (Reb M) is a zero-calorie sweetener with production issues due to its low yield and purity when synthesized from rebaudioside D (Reb D).
  • Researchers identified a modified enzyme variant (UGT76G1-L200A/L379M) that improved catalytic efficiency by ten times compared to the original enzyme, allowing for a higher yield of Reb M.
  • The study also revealed that molecular interactions in the modified enzyme contribute to this enhanced efficiency, showcasing a new approach in protein engineering for better enzymatic performance.
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  • * The text outlines a specific protocol for tyramide signal amplification (TSA) immunohistochemistry aimed at detecting Notch signaling components in blood vessels.
  • * It provides detailed steps including antigen retrieval, using specific blocking solutions, and a complex involving avidin/biotin-horseradish peroxidase conjugate with tyramide, as well as optimized washing procedures.
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The article reviews the clinical and mechanism researches of acupuncture-moxibustion in treatment of rheumatoid arthritis (RA) in recent two decades at home and abroad. The results indicate that acupuncture-moxibustion is conductive to RA with fewer adverse reactions for the patients, and improves joint function and quality of life to a certain extent. The therapeutic results of acupuncture-moxibustion result from the multi-target, multi-level collaborative effect on RA.

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  • Mesenchymal stem cells (MSCs) from gestational tissues are promising for treating congenital malformations but face challenges like invasiveness, prompting the exploration of less risky alternatives like naturally occurring exosomes (EXOs) and their mimics (MIMs) from amniotic fluid-derived MSCs (AF-MSCs).
  • The study involved creating MIMs, comparing their properties to EXOs, and evaluating their safety and distribution in a mouse model predisposed to neural tube defects.
  • Results indicated that MIMs and EXOs have similar characteristics, with MIMs yielding three times more product, and no adverse effects were found in pregnant mice, making MIMs a promising, minimally invasive therapeutic option.
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Uveitis, an autoimmune disease, often leads to blindness. CD4 T cells, including regulatory T cells (Tregs) and effector T cells (Th1 and Th17), play a critical role in its pathogenesis. Caloric restriction (CR) has been shown to alleviate autoimmune diseases.

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Introduction: Cancer remains a leading cause of death globally, with patients frequently experiencing malnutrition due to both the disease and its treatment, which negatively affects their quality of life and treatment outcomes. Oral nutritional supplements (ONS) provide a noninvasive solution to improve nutritional status, but poor patient adherence limits their effectiveness. Studies on ONS adherence vary in their definitions and assessment tools, creating inconsistencies.

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Hydroxytyrosol has been proven beneficial to human health. However, the process involving the conversion of L-DOPA to 3,4-dihydroxyphenylacetaldehyde (3,4-DHPAA) in hydroxytyrosol biosynthesis typically required the simultaneous use of decarboxylase and oxidative deaminase. In addition, phenylacetaldehyde reductase from Solanum lycopersicum (SlPAR) in hydroxytyrosol biosynthesis exhibits poor thermal stability.

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Aeromonas hydrophila is a serious human and animal co-pathogenic bacterium. The type II secretion system (T2SS), a key virulence factor, is vital for the secretion of exotoxins from the bacterium. exeA gene is important for the assembly of the T2SS.

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Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterised by insulin resistance, hyperglycaemia, and inflammation, with oxidative stress contributing to its progression. Curcumin (CUR), known for its anti-inflammatory, antioxidant, and insulin sensitising effects, has shown potential for the treatment of T2DM but is limited by low solubility and bioavailability. This study investigated long-circulating curcumin-loaded liposomes (CUR-LPs) to improve curcumin stability, solubility, and circulation and assessed their effect on insulin resistance in a murine model of T2DM.

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Objectives: To explore the enhanced sensitization effect of peritumoral electroacupuncture (PEA) on doxorubicin (DOX) chemotherapy in mice with triple-negative breast cancer (TNBC).

Methods: Eighteen female Balb/c mice were randomly divided into the model, DOX, and EA+DOX groups, with 6 mice in each group. TNBC cells were injected into the mammary fat pad of mice to establish the breast cancer-bearing mice model.

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Objective: The optimal treatment strategy for the management of multiple sclerosis is widely discussed due to the increasing availability of high-efficacy disease-modifying agents (heDMAs). This study evaluated the comparative effectiveness of heDMA and moderate-efficacy disease-modifying agents (meDMAs) use in reducing annualized relapse rate (ARR) among multiple sclerosis patients.

Methods: A retrospective cohort study was conducted using the 2015-2019 United States Merative MarketScan Commercial Claims Data.

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In patients with multiple sclerosis (MS), infections represent a significant concern, particularly given the immunomodulatory effects of disease-modifying agents (DMAs). High-efficacy DMAs (heDMAs) play a pivotal role in delaying MS progression, yet their use also raises concerns regarding the risk of infection. This study aimed to compare the infection risk with the use of heDMA and moderate-efficacy disease-modifying agents (meDMAs) in MS patients.

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To investigate whether Tasquinimod can influence cisplatin resistance in drug-resistant ovarian cancer (OC) cell lines by regulating histone deacetylase 4 (HDAC4) or p21, we explored its effects on the cell cycle, and associated mechanisms. RT-PCR and Western blot analyses, flow cytometry, CCK8 assay, and immunofluorescence were utilized to investigate the effects of Tasquinimod on gene expression, cell cycle, apoptosis, viability, and protein levels in OC cells. The results showed that Tasquinimod inhibited cell viability and promoted apoptosis in SKOV3/DDP (cisplatin) and A2780/DDP cells more effectively than DDP alone.

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Background: Anxiety and depressive disorders, characterized by high incidence and functional impairments, are emotional disorders with shared etiological and maintenance mechanisms. Dialectical behavior therapy (DBT) is a promising approach for the transdiagnostic treatment of emotional disorders. Developing a brief DBT intervention can facilitate the adoption of evidence-based therapy.

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Uveitis is the leading cause of visual impairment worldwide. Interleukin-6 (IL-6), which is upregulated in response to inflammation, is one of the most important inflammatory cytokines associated with uveitis. Two major IL-6 receptors (IL-6R) mediate the pro-inflammatory and anti-inflammatory biological effects of IL-6.

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Background: The efficacy of delayed stenting strategies in the management of high thrombus burden acute myocardial infarction remains uncertain. We aimed to compare the therapeutic effects and financial implications of immediate and delayed stenting strategies in patients with acute myocardial infarction and high thrombus burden treated at our institution.

Methods: This was a retrospective analysis of 158 patients who underwent intracoronary thrombus aspiration for acute ST-elevation myocardial infarction (STEMI) at the Second Affiliated Hospital of Shantou University Medical College between 2013 and 2023.

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