Publications by authors named "Ying L Tsung"
Article Synopsis
- Interleukin (IL)-12 activates a strong immune response that can eliminate large tumors, but the specific mechanisms behind this effect are still unclear.
- The study reveals that the rejection of the MCA207 tumor by IL-12 does not rely on common pathways like perforin or nitric oxide, suggesting a unique mechanism.
- It was found that activated macrophages, especially those induced by a combination of cyclophosphamide and IL-12, are crucial for tumor rejection, as they can kill tumor cells through a novel method that persists even after cell fixation.
We have demonstrated previously that established small and large murine MCA207 sarcomas can be completely eradicated by treatment with interleukin (IL) 12 alone and cyclophosphamide plus IL-12 (Cy+IL-12), respectively. The antitumor effect of IL-12/Cy+IL-12 has been found to be dependent on IFN-gamma and T cells. The role of IFN-gamma in IL-12-induced tumor rejection is unclear, because after IL-12 administration IFN-gamma is produced by multiple cell types, and it acts on most cell types because of the ubiquitous expression of its receptor.
View Article and Find Full Text PDF