The high-quality development of tourism is crucial to the sustainable development of regional economy. To evaluate high-quality tourism development, this paper has developed an index system with 6 second-level indicators and 24 third-level indicators and used methods of entropy-weight, AHP, and TOPSIS to empirically assess the high-quality tourism development of 9 cities in Fujian Province. According to the results, there are obvious regional differences in the development of high-quality tourism in Fujian Province.
View Article and Find Full Text PDFA vertical-type InGaN light-emitting diode with a resonant cavity was demonstrated with a 9 μm aperture size and a short cavity formed by hybrid distributed Bragg reflectors (DBRs). The approach involved designing epitaxial structures and utilizing an electrochemical etching process to convert heavily doped n-type gallium nitride (n-GaN) layers into porous GaN layers as a porous-GaN DBR structure. Thirteen pairs of the conductive porous-GaN:Si/GaN:Si DBR structure provided a vertical current path in a vertical-type light-emitting diodes (LED) structure.
View Article and Find Full Text PDFObjective: To explore the efficacy of serplulimab plus chemotherapy in esophageal squamous cell carcinoma (ESCC) patients with liver metastases.
Methods: A post hoc exploratory analysis of ASTRUM-007 study was performed, focusing on the association between the liver metastases status and the clinical outcomes. A systematic literature search of electronic databases was conducted to identify eligible randomized controlled trials for the meta-analysis.
Background: Only a few cases have been reported about active foreign body implantation in the cavernous body of the penis.
Case Presentation: A 47-year-old man inserted two needles from the glans penis into the bilateral penile sponge body. Subsequently, two needles migrated through the penile cavernous body into the pelvic cavity.
Kidney Blood Press Res
April 2024
Introduction: Upper urinary tract stones combined with parenchymal infiltrative renal pelvic cancer are challenging to detect on imaging and to evaluate the differential diagnosis.
Case Presentation: The symptoms and diagnoses in three cases of parenchymal infiltrative renal pelvic cancer and upper urinary tract stones that occurred between June 2019 and June 2022 were reviewed. Primary symptoms of lumbar discomfort and hematuria were evident in all 3 patients.
Comput Biol Med
February 2024
Comprehensive and exceedingly precise centralized patient monitoring has become essential to advance predictive, preventive, and efficient patient care in contemporary healthcare. Millimeter-wave (mmWave) technology, boasting high-frequency and high-speed wireless communication, holds promise as a viable solution to this challenge. This paper presents a new approach that combines mmWave communication and computer vision (CV) to achieve real-time patient monitoring and data transmission in indoor medical environments.
View Article and Find Full Text PDFObjective: Peritoneal dialysis-related peritonitis (PDRP) presents a significant challenge for nephrologists. Continuous intraperitoneal cefazolin and ceftazidime are recommended for the treatment of peritonitis. However, some pharmacokinetic studies have shown that doses of 15-20 mg/kg/d may not achieve sufficient therapeutic levels.
View Article and Find Full Text PDFJ Therm Biol
October 2023
Ambient temperature and the bedding thermal resistance are two key factors affecting sleepers' thermal comfort. Six duvets with thermal resistance of 3.81, 5.
View Article and Find Full Text PDFJanus kinases (JAKs) play a critical role in modulating the function and expression of inflammatory cytokines related to rheumatoid arthritis (RA). Herein, we report the design, synthesis, and structure-activity relationships (SARs) of a series of novel quinazoline derivatives as JAK inhibitors. Among these inhibitors, compound 11n showed high potency against JAKs (JAK1/JAK2/JAK3/TYK2, IC = 0.
View Article and Find Full Text PDFThis study tested if matrix metalloproteinase (MMP)-9 promoted microvascular pathology that initiates hypertensive (HT) kidney disease in salt-sensitive (SS) Dahl rats. SS rats lacking Mmp9 (Mmp9) and littermate control SS rats were studied after one week on a normotensive 0.3% sodium chloride (Pre-HT SS and Pre-HT Mmp9) or a hypertension-inducing diet containing 4.
View Article and Find Full Text PDFUnlabelled: Accurate estimates of bacterial carbon metabolic rates are indispensable for understanding the regulation of carbon fluxes in aquatic environments. Here, changes in bacterial growth, production, and cell volume in both pre-filtered and unfiltered seawater during 24 h incubation were monitored. The methodological artifacts during Winkler bacterial respiration (BR) measurements in subtropical Hong Kong coastal waters were assessed.
View Article and Find Full Text PDFIn this paper, a multifunctional terahertz (THz) absorber based on Dirac semimetal and vanadium dioxide ( ) is proposed. By modulating the temperature of , the absorber can be switched between the narrow band and wide band. When is in the metallic state, the absorber has a broadband absorption effect with a bandwidth of approximately 4 THz.
View Article and Find Full Text PDFFirst-line systemic therapeutic options for advanced esophageal squamous cell carcinoma (ESCC) are limited. In this multicenter, double-blind phase 3 trial, a total of 551 patients with previously untreated, locally advanced or metastatic ESCC and PD-L1 combined positive score of ≥1 were randomized (2:1) to receive serplulimab (an anti-PD-1 antibody; 3 mg/kg) or placebo (on day 1), plus cisplatin (50 mg/m) (on day 1) and continuous infusion of 5-fluorouracil (1,200 mg/m) (on days 1 and 2), once every 2 weeks. The study met the primary endpoints.
View Article and Find Full Text PDFUltraviolet-C AlGaN resonant-cavity light-emitting diodes with top and bottom pipe-AlGaN-distributed Bragg reflectors (DBRs) have been demonstrated. For the top/bottom DBR structures, 20 pairs of n-AlGaN:Si/n-AlGaN:Si stack structures were transformed into the pipe-AlGaN:Si/n-AlGaN:Si DBRs through a doping-selective electrochemical wet etching process. The reflectivity of the pipe-AlGaN DBR structure was measured as 90% at 276.
View Article and Find Full Text PDFNew data are accumulating on the involvement of interaction among circular RNAs (circRNAs), microRNAs (miRNAs/miRs), and messenger RNAs (mRNAs) in cerebral infarction (CI). This study aims to illustrate the GEO database-based identification of a circRNA-miRNA-mRNA crosstalk network underlying immune cell infiltration in CI. The differential analysis suggested that 1696 circRNAs, 1989 miRNAs, and 5550 mRNAs that were differentially expressed in CI samples were retrieved from GEO database.
View Article and Find Full Text PDFQuilts play a vital role in the thermal comfort of sleeping people. This study aims to investigate the comfortable indoor temperatures and thermal responses when people sleep in different quilts. The experiment tested three kinds of quilts (down, silk, and polyester), and each kind of quilt involved six filling weights.
View Article and Find Full Text PDFRenin is the rate-limiting enzyme in the renin-angiotensin-aldosterone system (RAAS) which regulates blood pressure and renal function and hence is an attractive target for the treatment of hypertension and cardiovascular/renal diseases. However, the development of direct renin inhibitors (DRIs) with favorable oral bioavailability has been a longstanding challenge for many years. This problem was thought to be because most of the reported DRIs were peptide-like structures or nonpeptide-like structures with a molecular weight (MW) of > 600.
View Article and Find Full Text PDFPrevention of phenotype switching of vascular smooth muscle cells is an important determinant of normal vascular physiology. Hydrogen peroxide (HO) promotes osteogenic differentiation of vascular smooth muscle cells through expression of Runt related transcription factor 2 (Runx2). In this study, an increase in dietary NaCl increased endothelial HO generation through NOX4, a NAD(P)H oxidase.
View Article and Find Full Text PDFInt J Occup Saf Ergon
June 2023
Workwear is urgently needed in mining that is applied to ensure the basic safety and performance of miners. However, the protective and ergonomic functions of workwear are limited. This study aimed to develop and evaluate a new design of mining workwear.
View Article and Find Full Text PDFSmall-molecule irreversible tyrosine kinase inhibitors as high potent agents have led to improvements in disease-free and overall survival in patients with HER2-amplified cancer. The approved irreversible HER2 inhibitors, neratinib and pyrotinib, both lack HER2 selectivity, leading to off-target adverse events in patients. The development of HER2 mutation during treatment also hampers the progress of the treatment.
View Article and Find Full Text PDFColorectal cancer (CRC) is the most common gastrointestinal cancer, with a high mortality rate but limited therapeutic targets. DIRAS family GTPase 2 () is a member of the Ras-related small G-protein family whose biological functions and underlying mechanism in CRC remain poorly understood. In this study, we identified the crucial roles of DIRAS2 in CRC.
View Article and Find Full Text PDFBackground: Alveolar echinococcosis (AE) can cause severe liver fibrosis and could be fatal if left untreated. Currently, there are no effective therapeutic options for AE-induced liver fibrosis. In view of the therapeutic potential of adipose-derived stem cells (ADSCs), we investigated whether ADSCs transplantation has the ability to control or reverse fibrosis progression in the liver of Echinococcus multilocularis (E.
View Article and Find Full Text PDFBackground: Alveolar echinococcosis (AE) is a chronic disease caused by the larval stage of Echinococcus multilocularis. Assessing the metabolic activity of AE lesions is critical to evaluate disease progression and survey treatment options. There is an urgent need to identify more rapid, convenient, and non-invasive clinical detection methods to substitute the current techniques.
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