Matrix metalloproteinase-9 regulates afferent arteriolar remodeling and function in hypertension-induced kidney disease.

This study tested if matrix metalloproteinase (MMP)-9 promoted microvascular pathology that initiates hypertensive (HT) kidney disease in salt-sensitive (SS) Dahl rats. SS rats lacking Mmp9 (Mmp9) and littermate control SS rats were studied after one week on a normotensive 0.3% sodium chloride (Pre-HT SS and Pre-HT Mmp9) or a hypertension-inducing diet containing 4.

[Clinical application of virtual surgery combined with guide plate in reduction and fixation of condylar neck fracture in 7 patients].

Purpose: To explore the value of virtual surgery and 3D printing model combined with guide plate in treatment of mandibular condylar neck fracture.

Methods: Seven patients with mandibular condylar neck fracture were scanned by CT for original data. The data were exported in DICOM format.

Long non-coding RNA human leucocyte antigen complex group-18 HCG18 (HCG18) promoted cell proliferation and migration in head and neck squamous cell carcinoma through cyclin D1-WNT pathway.

Emerging evidence has demonstrated that long noncoding RNA (lncRNAs) play a vital role in the development of head and neck squamous cell carcinoma (HNSCC); however, the biological effects and underlying mechanisms of human leukocyte antigen complex group-18 HCG18 (HCG18) have not yet been reported in HNSCC. In this study, we detected the expression of the HCG18 in HNSCC cell lines and patient tissues. We observed that HCG18 was upregulated in HNSCC patient tissues and cell lines.

Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4.

Prevention of phenotype switching of vascular smooth muscle cells is an important determinant of normal vascular physiology. Hydrogen peroxide (HO) promotes osteogenic differentiation of vascular smooth muscle cells through expression of Runt related transcription factor 2 (Runx2). In this study, an increase in dietary NaCl increased endothelial HO generation through NOX4, a NAD(P)H oxidase.

Cellular antioxidant mechanisms control immunoglobulin light chain-mediated proximal tubule injury.

A major cause of morbidity and mortality in multiple myeloma is kidney injury from overproduction of monoclonal immunoglobulin light chains (FLC). FLC can induce damage through the production of hydrogen peroxide, which activates pro-inflammatory and pro-apoptotic pathways. The present study focused on catalase, a highly conserved antioxidant enzyme that degrades hydrogen peroxide.

USP8 and TP53 Drivers are Associated with CNV in a Corticotroph Adenoma Cohort Enriched for Aggressive Tumors.

Context: Pituitary corticotroph adenomas are rare tumors that can be associated with excess adrenocorticotropin (ACTH) and adrenal cortisol production, resulting in the clinically debilitating endocrine condition Cushing disease. A subset of corticotroph tumors behave aggressively, and genomic drivers behind the development of these tumors are largely unknown.

Objective: To investigate genomic drivers of corticotroph tumors at risk for aggressive behavior.

[Investigation of surgical - orthodontic treatment of dentigerous cysts in 19 children and adolescents].

Purpose: To evaluate the therapeutic effect of dentigerous cysts in children and adolescents with surgical windowing and orthodontic traction.

Methods: A total of 19 cases were collected from the First People 's Hospital of Yongkang between 2014 to 2016. All cases were treated with surgical windowing and orthodontic traction.

Correction: Mendelian and Non-Mendelian Regulation of Gene Expression in Maize.

[This corrects the article DOI: 10.1371/journal.pgen.

miR-324-3p promotes gastric cancer development by activating Smad4-mediated Wnt/beta-catenin signaling pathway.

Background: Emerging evidence suggested that miRNAs can function as oncogenes or tumor suppressors by regulating downstream target genes. miR-324-3p has been reported to function in several carcinomas, but its role in gastric cancer (GC) is still unknown. This study aims to explore the effects of miR-324-3p on the development of GC.

[Desensitizing effect of stannous fluoride-containing toothpaste for patients with dentine hypersensitivity: a Meta-analysis].

Objective: This study aims to assess the effects of desensitizing toothpaste containing stannous fluoride on dentine hypersensitivity by performing Meta-analysis of randomized controlled trials (RCT) involving the treatment of dentine hypersensitivity with stannous fluoride-containing toothpaste.

Methods: The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.

A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men.

Evaluation of cancer genomes in global context is of great interest in light of changing ethnic distribution of the world population. We focused our study on men of African ancestry because of their disproportionately higher rate of prostate cancer (CaP) incidence and mortality. We present a systematic whole genome analyses, revealing alterations that differentiate African American (AA) and Caucasian American (CA) CaP genomes.

[Methodological and reporting quality assessment for Chinese systematic reviews and meta analysis in oral medicine].

Purpose: To evaluate the methodology and reporting quality of Chinese systematic reviews and meta analysis in oral medicine.

Methods: Chinese literatures of systematic reviews and meta analysis in oral medicine were searched in the CBM, VIP, WANFANG Database and CNKI from the establishment date to August 30, 2014. Two researchers screened and evaluated the data independently, and disagreements were resolved by discussion.

Multicolor Photodetector of a Single Er(3+)-Doped CdS Nanoribbon.

Er(3+)-doped CdS nanoribbons (Er-CdS NRs) are synthesized by thermal evaporation and then characterized by field emission scanning electron microscopy (FE-SEM), high-resolution transmission electron microscopy (HRTEM), photoluminescence (PL), and absorption spectra. The Er-CdS NR photodetector is studied systematically, including spectral response, light intensity response, and photoconductance (G) versus temperature (T). It is found that Er-CdS NR has the ability of detecting multicolor light including blue, red, and near-infrared light with higher responsivity (R λ ) and external quantum efficiency (η).

Copy number variation detection using next generation sequencing read counts.

Background: A copy number variation (CNV) is a difference between genotypes in the number of copies of a genomic region. Next generation sequencing (NGS) technologies provide sensitive and accurate tools for detecting genomic variations that include CNVs. However, statistical approaches for CNV identification using NGS are limited.

Mendelian and non-Mendelian regulation of gene expression in maize.

Transcriptome variation plays an important role in affecting the phenotype of an organism. However, an understanding of the underlying mechanisms regulating transcriptome variation in segregating populations is still largely unknown. We sought to assess and map variation in transcript abundance in maize shoot apices in the intermated B73 × Mo17 recombinant inbred line population.

Changes in genome content generated via segregation of non-allelic homologs.

A careful analysis of two maize recombinant inbred lines (RILs) relative to their inbred parents revealed the presence of several hundred apparently de novo copy number variants (CNVs). These changes in genome content were validated via both PCR and whole exome-array capture-and-sequencing experiments. One hundred and eighty-five genomic regions, which overlap with 38 high-confidence genes, exhibited apparently de novo copy number variation (CNV) in these two RILs and in many instances the same apparently de novo CNV events were observed in multiple RILs.

Posterior lumbar vein off the retrohepatic inferior vena cava: a novel anatomical variant with surgical implications.

Purpose: Resection of tumors involving the inferior vena cava requires vascular control of posteriorly draining lumbar veins to ensure a bloodless field. Surgical texts and atlases assert that lumbar veins do not insert into the inferior vena cava superior to the renal hilum. However, at our institution we have encountered patients undergoing inferior vena cava tumor thrombectomy who have a posterior lumbar vein cephalad to the renal veins.

Duplicated vena cava with tumor thrombus from renal cancer: use of venogram for safer operative planning.

Renal and adrenal tumors can invade into the inferior vena cava (IVC) in 4%-10% of cases. Consequently, urologists must remain well versed in the anatomy of the IVC. The IVC develops embryologically from the coordinated growth and regression of a series of veins.

[Treatment of 37 cases with panfacial fracture].

Purpose: To report the treatment experience of panfacial fracture.

Methods: Thirty-seven patients with panfacial fracture were treated with rigid internal fixation combined with intermaxillary or craniomaxillary traction. The fracture was repositioned in the order of "from fixed to mobile and from simple to complex".

B73-Mo17 near-isogenic lines demonstrate dispersed structural variation in maize.

Recombinant inbred lines developed from the maize (Zea mays ssp. mays) inbreds B73 and Mo17 have been widely used to discover quantitative trait loci controlling a wide variety of phenotypic traits and as a resource to produce high-resolution genetic maps. These two parents were used to produce a set of near-isogenic lines (NILs) with small regions of introgression into both backgrounds.

High-resolution genotyping via whole genome hybridizations to microarrays containing long oligonucleotide probes.

To date, microarray-based genotyping of large, complex plant genomes has been complicated by the need to perform genome complexity reduction to obtain sufficiently strong hybridization signals. Genome complexity reduction techniques are, however, tedious and can introduce unwanted variables into genotyping assays. Here, we report a microarray-based genotyping technology for complex genomes (such as the 2.

Genome-wide patterns of genetic variation among elite maize inbred lines.

We have resequenced a group of six elite maize inbred lines, including the parents of the most productive commercial hybrid in China. This effort uncovered more than 1,000,000 SNPs, 30,000 indel polymorphisms and 101 low-sequence-diversity chromosomal intervals in the maize genome. We also identified several hundred complete genes that show presence/absence variation among these resequenced lines.

Repeat subtraction-mediated sequence capture from a complex genome.

Sequence capture technologies, pioneered in mammalian genomes, enable the resequencing of targeted genomic regions. Most capture protocols require blocking DNA, the production of which in large quantities can prove challenging. A blocker-free, two-stage capture protocol was developed using NimbleGen arrays.