miRNA‑22‑3p inhibits cell viability and metastasis of nasopharyngeal carcinoma by targeting FOXP1.

Nasopharyngeal carcinoma (NPC) is a malignant tumor with a high incidence rate in certain regions. MicroRNA (miRNA/miR)-22-3p is implicated in the regulation of tumorigenesis and progression. However, the biological role of miRNA-22-3p in the progression of NPC remains unclear.

Molecular disturbances and thyroid gland dysfunction in rats chronically exposed to a high dose of NaAsO₂: Insights from proteomic and phosphoproteomic analyses.

Arsenic is a ubiquitous hazardous metalloid that poses a significant threat to human health. Although researchers have investigated the detrimental effects of arsenic on the thyroid, a comprehensive exploration of its toxicological impact and underlying molecular mechanisms remains to be conducted. Both this study and our previous reports demonstrated that chronic exposure to sodium arsenite (NaAsO) results in histological impairment and dysfunction of the thyroid glands in Sprague-Dawley (SD) rats.

Curcumin-carbon dots suppress periodontitis via regulating METTL3/IRE1α signaling.

This study aimed to investigate the effects of curcumin-carbon dot conjugates (CUR-CD) on periodontitis. Porphyromonas gingivalis lipopolysaccharide (LPS) was used to establish periodontitis mode in vivo and in vitro. Histological analysis was conducted using hematoxylin and eosin (HE) staining.

Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation.

Implant-associated Staphylococcus aureus (S. aureus) osteomyelitis (IASO) leads to high orthopedic implant failure rates due to the formation of Staphylococcal abscess community within the bone marrow and bacterial colonization in the osteocyte lacuno-canalicular network (OLCN). To address this, antimicrobial peptides (HHC36)-loaded titania nanotubes (NTs) are developed on titanium screws (Ti-NTs-P-A), which integrate pH-responsive polymethacrylic acid to control HHC36 release for eradicating bacteria in IASO.

Ligamental reconstruction improved the functional outcomes of patients with anterior cruciate ligament injury and early-stage symptomless osteoarthritis.

Background: The optimal treatment for anterior cruciate ligament (ACL) injuries with early-stage symptomless osteoarthritis (OA) remains unclear. This study aimed to compare the clinical outcomes of ACL reconstruction (ACLR) in patients with ACL injury in the presence and absence of early-stage symptomless OA.

Methods: Medical records of patients with early-stage symptomless OA who sustained ACL injury and underwent ACLR from January 2018 to December 2020 at a single institution were retrospectively reviewed.

PENTAGON: Physics-enhanced neural network for volumetric flame chemiluminescence tomography.

This study proposes a physics-enhanced neural network, PENTAGON, as an inference framework for volumetric tomography applications. By leveraging the synergistic combination of data-prior and forward-imaging model, we can accurately predict 3D optical fields, even when the number of projection views decreases to three. PENTAGON is proven to overcome the generalization limitation of data-driven deep learning methods due to data distribution shift, and eliminate distortions introduced by conventional iteration algorithms with limited projections.

Pseudokinase STK40 promotes T1 and T17 cell differentiation by targeting FOXO transcription factors.

Inappropriate CD4 T helper (T) cell differentiation leads to progression of inflammatory and autoimmune diseases, yet the regulatory mechanisms governing stability and activity of transcription factors controlling T cell differentiation remain elusive. Here, we describe how pseudokinase serine threonine kinase 40 (STK40) facilitates T1/T17 differentiation under pathological conditions. STK40 in T cells is dispensable for immune homeostasis in resting mice.

A narrow complex tachycardia with a short HV interval: What is the mechanism?

The case was a 15-year-old male with a history of paroxysmal supraventricular tachycardia refractory to medical therapy and prior catheter. A repeat electrophysiology study and catheter ablation were applied. Baseline AH and HV intervals were 100 and 55 ms during normal sinus rhythm (NSR), respectively.

Ferroptosis as a new tool for tumor suppression through lipid peroxidation.

As a newly defined type of programmed cell death, ferroptosis is considered a potent weapon against tumors due to its distinct mechanism from other types of programmed cell death. Ferroptosis is triggered by the uncontrolled accumulation of hydroperoxyl polyunsaturated fatty acid-containing phospholipids, also called lipid peroxidation. The lipid peroxidation, generated through enzymatic and non-enzymatic mechanisms, drives changes in cell morphology and the destruction of membrane integrity.

Hypermethioninemia due to methionine adenosyltransferase I/III deficiency and brain damage.

Background And Objectives: Methionine adenosyltransferase I/III deficiency used to be considered a relatively benign disease. This study aims to elucidate the clinical characteristics of methionine adenosyltransferase I/III deficiency patients with neurological manifestations.

Methods: The clinical data, blood amino acids, plasma total homocysteine, gene variants, brain imaging, treatments and outcomes of 15 patients with methionine adenosyltransferase I/III deficiency were retrospectively analyzed.

Rituximab induces ferroptosis and RSL3 overcomes rituximab resistance in diffuse large B-cell lymphoma cells.

Diffuse large B-cell lymphoma (DLBCL) is the most common malignant lymphoma in adults, and the use of rituximab has greatly improved the survival of DLBCL patients. Currently, the first-line treatment regimen for DLBCL is still rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), which significantly improves outcomes for DLBCL patients. However, a percentage of patients still experience refractory or relapsed disease.

Fourier phase retrieval using physics-enhanced deep learning.

Fourier phase retrieval (FPR) aims to reconstruct an object image from the magnitude of its Fourier transform. Despite its widespread utility in various fields of engineering and science, the inherent ill-posed nature of the FPR problem poses a significant challenge. Here we propose a learning-based approach that incorporates the physical model of the FPR imaging system with a deep neural network.

Evaluation of four machine learning methods in predicting orthodontic extraction decision from clinical examination data and analysis of feature contribution.

Introduction: The study aims to predict tooth extraction decision based on four machine learning methods and analyze the feature contribution, so as to shed light on the important basis for experts of tooth extraction planning, providing reference for orthodontic treatment planning.

Methods: This study collected clinical information of 192 patients with malocclusion diagnosis and treatment plans. This study used four machine learning strategies, including decision tree, random forest, support vector machine (SVM) and multilayer perceptron (MLP) to predict orthodontic extraction decisions on clinical examination data acquired during initial consultant containing Angle classification, skeletal classification, maxillary and mandibular crowding, overjet, overbite, upper and lower incisor inclination, vertical growth pattern, lateral facial profile.

Portable X-ray fluorescence of zinc and selenium with nail clippings-Mother and Infant Nutrition Investigation (MINI).

Zinc and selenium are essential minerals for human nutrition. Reliable biomarkers of zinc status and selenium status in humans are therefore important. This work investigates a novel portable X-ray fluorescence (XRF) method with the ability to rapidly assess zinc and selenium in nail clippings.

[Electroacupuncture preconditioning prevents urticaria by regulating inflammatory response in rats with urticaria].

Objectives: To observe the effect of electroacupuncture (EA) preconditioning at "Quchi" (LI11) and "Xuehai" (SP10) in prevention of urticaria.

Methods: Twenty-four male SD rats were randomly divided into control, model and preconditioning of EA (Pre-EA) groups (8 rats/group). The urticaria model was established by intradermal injection of dilute allogeneic antioalbumin serum at the spots of the bilateral symmetry of the spine on the back, and followed by tail venous injection of mixture solution of egg albumin diluent, plus 0.

Enhancing cotton whitefly (Bemisia tabaci) detection and counting with a cost-effective deep learning approach on the Raspberry Pi.

Background: The cotton whitefly (Bemisia tabaci) is a major global pest, causing significant crop damage through viral infestation and feeding. Traditional B. tabaci recognition relies on human eyes, which requires a large amount of work and high labor costs.

Psychological responses and factors associated with depression and anxiety in entry personnel under quarantine during pandemic in China.

Background: The global COVID-19 pandemic has highlighted critical concerns surrounding mental health. Social isolation measures, such as the quarantine of incoming travelers, are essential public health strategies for the prevention and control of infectious diseases. However, quarantine can lead to adverse psychological outcomes, including feelings of confinement, boredom, perceived scarcity of supplies and information, financial hardship, and social stigma.

A call for improving of musculoskeletal education on physical medicine and rehabilitation studies: a systematic review with meta-analysis.

Background: The incidence of musculoskeletal diseases is increasing in clinical practice, leading to a growing demand for rehabilitation medicine. However, education in musculoskeletal education is lacking in the training of physical medicine and rehabilitation students. This study aims to evaluate the impact of musculoskeletal education on medical students' learning of rehabilitation medicine and analyze the correlation between influencing factors and education.