Publications by authors named "Ying Jang"
Acyclovir is commonly used to prevent and treat herpes simplex virus (HSV) reactivation after hematopoietic cell transplant (HCT), and only few reports have been published on acyclovir-resistant HSV in HCT recipients. We reviewed the medical records of patients with a microbiologic diagnosis of acyclovir-resistant HSV by plaque reduction test who received an HCT from 2002 through 2014. A total of 4 028 HCTs were performed during the study period, and 18 of the recipients met the diagnostic criteria for acyclovir-resistant HSV.
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- PTEN is a crucial tumor suppressor that influences cell functions, and its specific role in squamous cell carcinoma (SCC) of the tongue is not fully understood.
- The study established a cell line to examine how PTEN affects SCC-4 cell proliferation, invasion, and apoptosis, finding that it induces cell death through the inhibition of a certain signaling pathway.
- PTEN also regulates the epithelial-mesenchymal transition, enhancing E-cadherin (which hampers invasion) while reducing proteins like vimentin and SNAIL, thus providing insights into its role in tongue carcinoma progression and metastasis.
Small guanosine triphosphatases (GTPases) become activated when GDP is replaced by GTP at the highly conserved nucleotide binding site. This process is intrinsically very slow in most GTPases but is significantly accelerated by guanine nucleotide exchange factors (GEFs). Nucleotide exchange in small GTPases has been widely studied using spectroscopy with fluorescently tagged nucleotides.
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