Clinical analysis of colistin sulfate in the treatment of pneumonia caused by carbapenem-resistant Gram-negative bacteria.

Background: Multidrug-resistant Gram-negative bacteria, exacerbated by excessive use of antimicrobials and immunosuppressants, are a major health threat.

Aim: To study the clinical efficacy and safety of colistin sulfate in the treatment of carbapenem-resistant Gram-negative bacilli-induced pneumonia, and to provide theoretical reference for clinical diagnosis and treatment.

Methods: This retrospective analysis involved 54 patients with Gram-negative bacilli pneumonia admitted to intensive care unit of The General Hospital of the Northern Theater Command of the People's Liberation Army of China from August 2020 to June 2022.

[Association between vaccination and the risk of immunoglobulin A vasculitis in children].

Objectives: To study the effect of vaccination on the short-term risk of immunoglobulin A vasculitis (IgAV) in children.

Methods: A retrospective analysis was conducted on the general data and the vaccination history within one year prior to onset in children with IgAV hospitalized in the Children's Hospital Affiliated to Zhengzhou University from November 2021 to January 2023. Vaccine exposure rates in the risk period (3 months prior to IgAV onset) and the control period were compared by autocontrol-case crossover analysis, and the odds ratio and 95% confidence interval (95%) were calculated.

Potential contribution of the gut microbiota to the development of portal vein thrombosis in liver cirrhosis.

Background: Portal vein thrombosis (PVT) is a serious complication of liver cirrhosis (LC) and is closely related to gut homeostasis. The study aimed to investigate the composition of gut microbiota and its putative role in PVT development in LC.

Methods: 33 patients with LC admitted between January 2022 and December 2022 were enrolled in this study.

[Relationship between coronavirus disease 2019 vaccination and the risk of immune thrombocytopenia].

Objectives: To study the relationship between coronavirus disease 2019 (COVID-19) vaccination and the risk of immune thrombocytopenia (ITP).

Methods: A retrospective analysis was conducted on children aged 3-17 years with newly diagnosed ITP who were hospitalized in Children's Hospital Affiliated to Zhengzhou University from November 2021 to December 2022. Clinical data and COVID-19 vaccination status were compared among three groups: ITP patients vaccinated within 12 weeks before onset, vaccinated more than 12 weeks before onset, and unvaccinated.

Immobilization of the Polar Group into an Ultramicroporous Metal-Organic Framework Enabling Benchmark Inverse Selective CO/CH Separation with Record CH Production.

One-step harvest of high-purity light hydrocarbons without the desorption process represents an advanced and highly efficient strategy for the purification of target substances. The separation and purification of acetylene (CH) from carbon dioxide (CO) by CO-selective adsorbents are urgently demanded yet are very challenging owing to their similar physicochemical properties. Here, we employ the pore chemistry strategy to adjust the pore environment by immobilizing polar groups into an ultramicroporous metal-organic framework (MOF), achieving one-step manufacture of high-purity CH from CO/CH mixtures.

Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.

Cyclic GMP-AMP synthase (cGAS), a cytosolic DNA sensor, acts as a nucleotidyl transferase that catalyzes ATP and GTP to form cyclic GMP-AMP (cGAMP) and plays a critical role in innate immunity. Hyperactivation of cGAS-STING signaling contributes to hyperinflammatory responses. Therefore, cGAS is considered a promising target for the treatment of inflammatory diseases.

Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain.

The B-cell lymphoma 2 (BCL-2) protein family plays a pivotal role in regulating the apoptosis process. BCL-2, as an antiapoptotic protein in this family, mediates apoptosis resistance and is an ideal target for cell death strategies in cancer therapy. Traditional treatment modalities target BCL-2 by occupying the hydrophobic pocket formed by BCL-2 homology (BH) domains 1-3, while in recent years, the BH4 domain of BCL-2 has also been considered an attractive novel target.

Two-Dimensional Metal-Organic Framework with Ultrahigh Water Stability for Separation of Acetylene from Carbon Dioxide and Ethylene.

Highly selective separation and purification of acetylene (CH) from ethylene (CH) and carbon dioxide (CO) are daunting challenges in light of their similar molecule sizes and physical properties. Herein, we report a two-dimensional (2D) stable metal-organic framework (MOF), ([Cu(Hmpba)]·1.5DMF) (Hmpba = 4-(3,5-dimethyl-1-pyrazol-4-yl)benzoic acid), with topology, stacked together through π-π interactions for efficient separation of CH from CH and CO.

Supplementation of guanidinoacetic acid and rumen-protected methionine increased growth performance and meat quality of Tan lambs.

Objective: Tan lambs (n = 36, 3 mo old, 19.1±0.53 kg) were used to assess effects of dietary guanidinoacetic acid (GAA) and rumen-protected methionine (RPM) on growth performance, carcass traits, meat quality, and serum parameters.

Propane-Trapping Ultramicroporous Metal-Organic Framework in the Low-Pressure Area toward the Purification of Propylene.

The propane (CH)-trapping adsorption behavior is considered as a potential performance to directly produce high-purity propylene (CH). Herein, we report an ultramicroporous Mn-based metal-organic framework () with a reverse CH-selective behavior in the low-pressure area. The pore structure of this material possesses more electronegative aromatic benzene rings for the stronger binding affinity to CH, and the material shows outstanding reverse ideal adsorbed solution theory (IAST) selectivity values.

In-situ synthesized porphyrin polymer/TiO composites as high-performance Z-scheme photocatalysts for CO conversion.

The promising photocatalytic conversion of CO into valuable fuel promotes the development of photocatalyst through various methods. In this work, TiO nanoparticle was composited with covalent porphyrin polymers (COP-Ps) to fabricate composite photocatalysts. The resultant COP-Ps/TiO composites by in situ hydrothermal method exhibit much improved photocatalytic activity for the conversion of CO into CO relative to two components, and it is attributable to improved charge transfer between two moieties led by strong interaction.

Recent Progress of Nanoscale Metal-Organic Frameworks in Synthesis and Battery Applications.

As one type of promising inorganic-organic hybrid crystal material, metal-organic frameworks (MOFs) have attracted widespread attention in many potential fields, particularly in energy storage and conversion. Recently, effective strategies have been developed to construct uniform nanoscale MOFs (NMOFs), which not only retain inherent advantages of MOFs but also develop some improved superiorities, including shorter diffusion pathway for guest transportation and more accessible active sites for surface adsorption and reaction. Additonally, their nanometer size provides more opportunity for post-functionalization and hybridization.

miR-296-5p Inhibits the Secretion of Pulmonary Surfactants in Pulmonary Epithelial Cells via the Downregulation of Wnt7b/-Catenin Signaling.

Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS.

Houttuynia cordata Thunb rescues retinal ganglion cells through inhibiting microglia activation in a rat model of retinal ischemia-reperfusion.

Aim: To determine whether Houttuynia cordata Thunb (HCT) can increase the survival of the retinal ganglion cells (RGCs) and inhibit microglia activation following retinal ischemia-reperfusion (RIR) injury.

Methods: Rat model of RIR was induced by transient elevation of the intraocular pressure (IOP). HCT was orally administered for 2d before the performance of retinal RIR model and once a day for the next 14d.

Small RNA Sequencing Reveals Differentially Expressed miRNAs in Necrotizing Enterocolitis in Rats.

Necrotizing enterocolitis (NEC) is the leading cause of death due to gastrointestinal disease in preterm infants. The role of miRNAs in NEC is still unknown. The objective of this study was to identify differentially expressed (DE) miRNAs in rats with NEC and analyze their possible roles.

Microporous Metal-Organic Framework with a Completely Reversed Adsorption Relationship for C Hydrocarbons at Room Temperature.

As a new type of porous material, metal-organic frameworks (MOFs) have been widely studied in gas adsorption and separation, especially in C hydrocarbons. Considering the stronger interaction between the unsaturated molecules and the metal sites, and the smaller molecular size of unsaturated molecules, the usual relationship of affinities and adsorption capacities among C hydrocarbons in most common MOFs is CH > CH > CH. Herein, a unique microporous metal-organic framework, (activated ), with a completely reversed adsorption relationship for C hydrocarbons (CH > CH > CH) has been successfully synthesized, which breaks the traditional concept of the adsorption relationship of MOFs for C hydrocarbons.

Visualizing the prediction of laser cleaning: a dynamic preview method with a multi-scale conditional generative adversarial network.

By producing high power per unit area and obtaining immediate feedback, lasers offer the potential for high-precision surface processing. However, due to having many complex and nonlinear physiochemical processes, unfitted values of parameters can easily result in undesired cleaning results: the substrate is either damaged or not cleaned. Thus, an accurate, flexible, and automatic image preview method is highly demanded in the cleaning practice.

Benchmark selectivity -xylene separation by a non-porous molecular solid through liquid or vapor extraction.

Solid-liquid separation of similarly sized organic molecules utilizing sorbents offers the potential for new energy-efficient approaches to a number of important industrial separations such as xylenes (C8) separations. Research on selective C8 sorption has tended to focus upon rigid porous materials such as zeolites and MOFs but has revealed generally weak selectivity that is inconsistent across the range of C8 molecules. Nevertheless, there are a few recent examples of non-porous molecular materials that exhibit relatively high selectivity for -xylene (X) from X/X, approaching that of the current benchmark X sorbent, the zeolite H/ZSM-5.

Inhibitory effect of Houttuynia cordata Thunb on LPS-induced retinal microglial activation.

Aim: To identify the effect of Houttuynia cordata Thunb (HCT) on lipopolysaccharide (LPS)-induced microglial activation and investigate its possible molecular mechanisms.

Methods: The primary retinal microglial cells were cultured from the retinas of newborn Sprague-Dawley rats and exposed to LPS, and/or HCT with different concentrations. The survival ability of retinal microglia cells was tested by standard MTT method.

Engineering Donor-Acceptor Heterostructure Metal-Organic Framework Crystals for Photonic Logic Computation.

Photonic materials use photons as information carriers and offer the potential for unprecedented applications in optical and optoelectronic devices. In this study, we introduce a new strategy for photonic materials using metal-organic frameworks (MOFs) as the host for the rational construction of donor-acceptor (D-A) heterostructure crystals. We have engineered a rich library of heterostructure crystals using the MOF NKU-111 as a host.

Rational Construction of Highly Tunable Donor-Acceptor Materials Based on a Crystalline Host-Guest Platform.

Organic donor-acceptor systems have attracted much attention due to their various potential applications. However, the rational construction and modulation of highly ordered donor-acceptor systems could be a challenge due to the complicated self-assembly process of donor and acceptor species. Considering the well-defined arrangement of species at the molecule level, a crystalline host-guest system could be an ideal platform for the rational construction of donor-acceptor systems.