Miniaturized thermal purge-and-trap device combined with self-calibration colorimetric/SERS dual-model optical sensors for highly rapid and selective detection of sulfur dioxide in wine.

Herein, the miniaturized thermal purge-and-trap (MTPT) device combined with self-calibration colorimetric/surface-enhanced Raman spectroscopy (SERS) dual-model optical sensors were designed for effective analysis of sulfur dioxide (SO) in wine. The SO can be rapidly separated from wine and enriched by MTPT device, ensuring colorimetric/SERS dual-model optical sensing based on Karl Fischer reaction. The high separation efficiency of miniaturized MTPT device combined with self-calibration of dual-model optical sensors significantly alleviate matrix interference and improve the detection accuracy.

Accurate attenuation characterization in optical coherence tomography using multi-reference phantoms and deep learning.

The optical attenuation coefficient (AC), a crucial tissue parameter indicating the rate of light attenuation within a medium, enables quantitative analysis of tissue properties and facilitates tissue differentiation. Despite its growing clinical significance, accurate quantification of AC from optical coherence tomography (OCT) signals remains a pressing concern. This study comprehensively investigates the factors influencing the accuracy of quantitative AC extraction among existing OCT-based AC extraction algorithms.

Stability and in vitro digestion behavior of astaxanthin-loaded Pickering emulsions stabilized by OSA-modified starch: Influence of oil phase content.

Astaxanthin, a lipid-soluble carotenoid, is widely recognized for its health-promoting properties. However, its use in functional foods is limited due to its low water solubility, chemical instability, and poor bioavailability. This study evaluated the potential of esterified starch-stabilized emulsions as astaxanthin carriers.

Prevention of Intrauterine Adhesion with Platelet-Rich Plasma Double-Network Hydrogel.

Intrauterine adhesion (IUA) can negatively impact on pregnancy outcomes, leading to reduced pregnancy rates, secondary infertility, and an increased risk of pregnancy complications. Studies have shown that the application of platelet-rich plasma (PRP) in IUA patients is effective. However, the clinical readhesive rate of IUA after treatment is still high, especially in severe cases.

Surface encapsulation of ZIF-8 on Ag nanoparticles modified cotton swab for highly rapid and selective surface-enhanced Raman spectroscopy analysis of glucose and lactic acid in human sweat.

Herein, ZIF-8 shell encapsulated Ag nanoparticles decorated cotton swab (CS@Ag@ZIF-8) was firstly designed and prepared for highly rapid and selective surface-enhanced Raman spectroscopy (SERS) analysis of glucose and lactic acid in human sweat. The CS not only act as support matrix for Ag modification and ZIF-8 encapsulation, but also provide great potential in-situ analysis of human sweat with low cost. The as-developed CS@Ag@ZIF-8 shows high SERS activity owing the good adsorption of ZIF-8 shell and electromagnetic enhancement of AgNPs.

The Study Progress and Analysis of Preventive Measures of Nursing Care for Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Hematologic Malignancies: A Retrospective Study.

Objective: To analyze the preventive and therapeutic effects of comprehensive nursing interventions on chemotherapy-induced oral mucositis in pediatric patients with hematologic malignancies.

Methods: A retrospective analysis was conducted, and 80 pediatric patients with hematologic malignancies who underwent chemotherapy in our hospital from January 2020 to December 2023 were selected as the research subjects. According to different nursing intervention methods, the patients were divided into an experimental group (45 cases) and a control group (35 cases).

Comparative metagenomics highlights the habitat-related diversity in taxonomic composition and metabolic potential of deep-sea sediment microbiota.

Sediment plays a pivotal role in deep-sea ecosystems by providing habitats for a diverse range of microorganisms and facilitates the cycling processes of carbon, sulfur and nitrogen. Beyond the normal seafloor (NS), distinctive geographical features such as cold seeps (CS) and hydrothermal vent (HV) are recognized as life oases harboring highly diverse microbial communities. A global atlas of microorganisms can reveal the notable association between geological processes and microbial colonization.

Influencing Factors Associated with Psychological Capital Among Ischemic Stroke Patients: A Latent Profile Analysis.

Background: China has the highest incidence of stroke worldwide because of a high rate of recurrence of ischemic stroke, which has significant negative impacts on the physical and mental health of patients. However, little research has been devoted to the psychological capital of ischemic stroke patients.

Purpose: To investigate the psychological capital of ischemic stroke patients, and uses latent profile analysis to identify the potential profiles of the psychological capital among patients as well as to explore heterogeneity within subgroups and the factors influencing it.

Topical 5-aminolevulinic acid-mediated photodynamic therapy versus loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia.

Objective: To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy (5-ALA PDT) and loop electrosurgical excision procedure (LEEP) among patients with cervical intraepithelial neoplasia (CIN).

Methods: We retrospectively identified patients who underwent either 5-ALA PDT or LEEP from Sep. 2012 to Dec.

Structural basis for the synergetic neutralization of hepatitis E virus by antibody-antibody interaction.

Neutralizing antibodies (nAbs) play a crucial role in virology, antibody drug development, and vaccine research. In this study, we investigated the synergistic effect of two hepatitis E virus (HEV) nAbs, 8H3, and 8C11, which have exhibited enhanced neutralizing activity in a rhesus monkey model. We presented crystal structures of 8H3 Fab alone and a triple complex of 8C11 Fab and 8H3 Fab simultaneously binding to the HEV E2s protein (8C11:E2s:8H3).

Design and fabrication of self-calibration colorimetric/fluorescence/SERS tri-modal optical sensor for highly rapid and accurate detection of mercury ions in foods.

The improvement of detection accuracy without loss of rapidity and sensitivity by optical sensors in complex food analysis is still full of challenges owing to the matrix interference. Herein, a novel and simple self-calibration colorimetric/fluorescence/surface-enhanced Raman spectroscopy (SERS) tri-modal optical sensor based on aminated Rhodamine 6G (R6G-NH) was developed for highly rapid, sensitive, and accurate detection of Hg in food samples. The high recognition specificity of R6G-NH for Hg can be achieved through the metal chelation interaction between Hg and -NH, -COOH groups in R6G-NH with formation of R6G-NH-Hg-R6G-NH complex.

Parallel beam splitting based on gradient metasurface: from classical to quantum.

Gradient metasurfaces are extensively utilized for polarized beam splitting (BS) in classical and quantum optics. Specifically, their phase gradient allows the path and polarization of multiple output lights to be locked by corresponding inputs. However, the full potential of this unique path-polarization-locked property in multi-beam splitting has not been investigated.

Proteomics-guided isolation of a novel serine protease with milk-clotting activity from tamarillo (Solanum betaceum Cav.).

Tamarillo is widely grown in Yunnan Province, China, and has been found that it can be used in cheese-making with a distinctive fruity flavour. However, this primary component responsible for curdling milk remains unclear. This study aimed to identify the main component in tamarillo responsible for curdling milk using proteomics and ammonium sulfate (AS) precipitation.

Molecular characterization of human HSPCs with different cell fates in vivo using single-cell transcriptome analysis and lentiviral barcoding technology.

Hematopoietic stem and progenitor cells (HSPCs) possess the potential to produce all types of blood cells throughout their lives. It is well recognized that HSPCs are heterogeneous, which is of great significance for their clinical applications and the treatment of diseases associated with HSPCs. This study presents a novel technology called Single-Cell transcriptome Analysis and Lentiviral Barcoding (SCALeBa) to investigate the molecular mechanisms underlying the heterogeneity of human HSPCs in vivo.

Spatiotemporal modeling of molecular holograms.

Quantifying spatiotemporal dynamics during embryogenesis is crucial for understanding congenital diseases. We developed Spateo (https://github.com/aristoteleo/spateo-release), a 3D spatiotemporal modeling framework, and applied it to a 3D mouse embryogenesis atlas at E9.

Defect-Engineering-Induced Vacancy-Rich BiS@AuNPs with Enhanced Photothermal Activity for Sensitive Bimodal-Type Gentamicin Monitoring.

One of the most promising approaches to effectively modulate the performance of immunochromatography (ICA) is the rational design of nanomaterials. It is anticipated to facilitate highly sensitive ICA analysis by introducing and controlling the internal defect structures of nanomaterials. Herein, we designed BiS@AuNPs with deep-level defect properties, revealing that these deep defects act as electron-hole nonradiative complex centers to promote phonon production, ultimately leading to photothermal analytical performance in ICA.

Association of maternal 25(OH)D levels during pregnancy with fetal birth weight and preschooler growth status: A retrospective birth cohort study.

Aim: There is limited and conflicting evidence available regarding the correlation between maternal vitamin D status and childhood overweight and body mass index (BMI). The aim of this study was to investigate the following: (1) potential association between maternal 25-hydroxyvitamin D (25(OH)D) levels and newborn growth status; (2) relationship between maternal 25OHD levels and BMI and the risk of overweight with preschoolers being overweight.

Methods: A cohort of 3213 eligible singleton mother-infant pairs were used to investigate the possible associations between maternal 25(OH)D levels and fetal growth status.

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging.

To systematically characterize the loss of tissue integrity and organ dysfunction resulting from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male mice during aging. We showed that senescence-sensitive spots (SSSs) colocalized with elevated entropy in organizational structure and that the aggregation of immunoglobulin-expressing cells is a characteristic feature of the microenvironment surrounding SSSs. Immunoglobulin G (IgG) accumulated across the aged tissues in both male and female mice, and a similar phenomenon was observed in human tissues, suggesting the potential of the abnormal elevation of immunoglobulins as an evolutionarily conserved feature in aging.

Structural insight into broadening SARS-CoV-2 neutralization by an antibody cocktail harbouring both NTD and RBD potent antibodies.

The continual emergence of highly pathogenic novel coronaviruses and their variants has underscored the importance of neutralizing monoclonal antibodies (mAbs) as a pivotal therapeutic approach. In the present study, we report the specific neutralizing antibodies 13H7 and 9G11, which target the N-terminal domain (NTD) and receptor-binding domain (RBD) of the SARS-CoV-2, respectively. The comparative analysis observed that 13H7 not only neutralizes early variants of concern (VOCs) but also exhibits neutralizing activity against the Omicron sublineage, including BA.

Respiratory pathogen analysis in pediatric inpatients unraveled the infection pattern of post the COVID-19 pandemic.

Background: To counteract the COVID-19 pandemic, nonpharmaceutical interventions (NPIs) were implemented globally, exerting a profound influence on a wide spectrum of infectious diseases, encompassing respiratory tract infections (RTIs). Subsequent to the easing of NPIs, China experienced a significant outbreak of (MP).

Methods: Over a decade from 2015 to 2024, our study scrutinized 12 common infectious diseases among pediatric children.

Behenic acid alleviates inflammation and insulin resistance in gestational diabetes mellitus by regulating TLR4/NF-κB signaling pathway.

Gestational diabetes mellitus (GDM) is a distinct form of diabetes that poses a significant threat to the health of both pregnant women and fetuses. The objective of this study was to investigate the impact of behenic acid (BA) on glucose metabolism, inflammation, and insulin resistance in GDM mice, and to elucidate the underlying molecular mechanism. Here, we demonstrated that daily administration of 10 mg/mL BA during pregnancy effectively ameliorated abnormal glucose metabolism in GDM mice and their offspring and improved birth outcomes in the offspring.