Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes.

Aim: We intended to examine the relationship between estimated glucose disposal rate (eGDR) and risks of all-cause and cardiovascular deaths in non-diabetic adults.

Methods: 38,175 participants from the National Health and Nutrition Examination Survey (1999-2018) were included, and deaths were identified through the National Death Index.

Results: With a median follow-up of 9.

Overexpression of α-synuclein in PDF neurons alters sleep-wake pattern by regulating lipid metabolism in Drosophila.

Parkinson's disease (PD) is a complex neurodegenerative disorder, characterized by the aggregation of α-synuclein (α-syn). Current research increasingly indicates the prevalence of sleep-wake disorders in early-stage PD, although the underlying pathogenic mechanisms remain unclear. In this study, transgenic Drosophila models were utilized to observe excessive daytime sleepiness and impaired anticipation in flies overexpressing α-syn in pan-neurons and circadian clock neurons.

Binge drinking and subsequent health and well-being among middled-aged Spanish adults: An outcome-wide analysis.

Background: Binge drinking has been associated with higher risks of adverse physical health outcomes. Motivations behind binge drinking may involve seeking pleasure and social connectedness, which are important aspects of life that constitute well-being. However, studies that apply a holistic framework of well-being to understand binge drinking remain limited, especially in non-English speaking populations.

Quantifying Biomass and Visualizing Cell Coverage on Fibrous Scaffolds for Cultivated Meat Production.

Cultivated meat represents a transformative solution to environmental and ethical concerns of traditional meat industries, replicating livestock meat's texture and sensory attributes in vitro with a focus on cost, safety, and nutritional quality. Central to this process are biomaterial scaffolds that support tissue development from isolated animal cells grown in or on these matrices. Understanding scaffold interactions with cells, including scaffold degradation and biomass production, is crucial for process design and for scaling-up goals.

Development of monoclonal antibodies against Mfa1 and their protective capacity in an experimental periodontitis model.

Unlabelled: (), a gram-negative, black-pigmented anaerobe, is a major etiological agent and a leading cause of periodontitis. Fimbriae protein Mfa1 is a key virulence factor of and plays a crucial role in bacterial adhesion, colonization, biofilm formation, and persistent inflammation, making it a promising therapeutic target. However, the role of anti-Mfa1 antibodies and the underlying protective mechanisms remain largely unexplored.

IIIVmrMLM.QEI: An effective tool for indirect detection of QTN-by-environment interactions in genome-wide association studies.

Although 3VmrMLM-MEJA and several indirect indicators have been employed to identify QTN-by-environment interactions (QEIs) in genome-wide association studies (GWAS), there is no convenient, flexible, and accurate method to comprehensively identify QEIs. To address this issue, 3VmrMLM-random was first extended to 3VmrMLM-fixed. Next, the two single-environment QTN detection methods were integrated with trait differences and regression parameters to indirectly detect QEIs.

Career choices and career mobility of chinese pharmacy graduates: a cross-sectional study.

Background: This study investigates the career mobility and employment status of Chinese pharmacy graduates, aiming to address workforce challenges and career planning within the pharmacy profession. Given the rapid expansion of the healthcare sector in China, understanding factors influencing job changes and career decisions is crucial for ensuring workforce stability and professional development. The study covers pharmacy graduates enrolled at Kunming Medical University from 1996 to 2012.

Resources Utilization Assessment and Cost-Minimization Analysis of the 6-Monthly Formulation of Triptorelin in the Treatment of Prostate Cancer in China.

Objective: Prostate Cancer can be treated with various formulations of Gonadotropin-Releasing Hormone Agonists (GnRHa), but cost analyses of these treatments in China are lacking. This study aims to evaluate the differences in cost and resource utilization between various formulations of GnRHa for Prostate Cancer by conducting a resource utilization assessment and cost minimization analysis.

Methods: From the perspective of society and medical healthcare, this study used the cost minimization model to generate cost and resource estimates for GnRHa drug acquisition and administration for "Current practice" and for a "Base case" scenario.

Morphometric Study on the Mandible of Colobine Fossil (Mesopithecus pentelicus) Found in East Asia, a Comparison With Extant Taxa.

A tooth-bearing mandible fossil of a colobine monkey discovered at Shuitangba, Zhaotong, Yunnan, China, was morphometrically analyzed and compared with extant Asian colobines. Our previous qualitative and quantitative descriptions indicate that it can be safely attributed to Mesopithecus pentelicus, a Miocene fossil colobine widely found in Europe and South Asia. The present research aims to explore fossil association with extant colobines and functionally propose its dietary preferences based on multivariate morphometric analyses of mandibular morphology.

Hyperbolic-Metamaterial-Based Optical Fiber SPR Sensor Enhanced by a Smart Hydrogel for Perspiration pH Measurements.

An optical fiber surface plasmon resonance (SPR) sensor, leveraging hyperbolic metamaterials (HMMs) and pH-sensitive hydrogels, has been devised for pH detection in perspiration. Dispersion-tunable HMMs enable the sensor to transcend the inherent structural constraints of an optical fiber and enhance its refractive index (RI) sensitivity. pH-sensitive hydrogels exhibit diverse swelling behaviors due to varying ionization degrees of carboxyl groups under different solution pH conditions, leading to a notable RI change.

Deniable ring signature scheme based on the ISRSAC digital signature algorithm.

This article introduces a deniable ring signature scheme within the framework of a ring signature protocol, which allows a member of the ring to assert or deny their role as the signature's originator without the involvement of a trusted third party. Deniable ring signatures find applications in various scenarios where balancing privacy protection with supervised oversight is crucial. In this work, we present a novel deniable ring signature scheme based on the ISRSAC digital signature, tailored for environments with regulatory requirements, empowering regulators to hold malicious signers accountable.

Is conduction system pacing more effective than right ventricular pacing in reducing atrial high-rate episodes in patients with heart failure and preserved ejection fraction?

Background: The relationship between conduction system pacing (CSP) and the incidence of atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF) remains uncertain. This study aims to investigate the occurrence of atrial high-rate episodes (AHREs) following CSP in patients with HFpEF, in comparison to right ventricular pacing (RVP).

Methods: Patients with HFpEF who received dual-chamber pacemakers for atrioventricular block were retrospectively enrolled from January 2018 to January 2023.

Dissolution Behavior of M5 Cladding in Hydrofluoric-Nitric Mixed Acid.

M5 cladding has emerged as a prominent fuel cladding material due to its excellent corrosion resistance. The dissolution behavior of M5 cladding is critical in both the initial cleaning stage and the reprocessing of spent fuel cladding. This study investigated the dissolution of M5 cladding in hydrofluoric-nitric (HF-HNO) mixed acid at varying concentrations.

Effects of Different Plasticizers on the Structure, Physical Properties and Film Forming Performance of Curdlan Edible Films.

This study successfully developed edible films with excellent mechanical strength and notable water resistance, utilizing curdlan (CL) as the primary matrix and incorporating various plasticizers, including glycerol (GLY), ethylene glycol (EG), propylene glycol (PRO), xylitol (XY), sorbitol (SOR), and polyethylene glycol (PEG). A comprehensive suite of analytical techniques, including Fourier transform infrared spectroscopy (FTIR), wide-angle X-ray diffraction (XRD), scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), and tensile testing, were employed to evaluate the films' structural and mechanical properties. After incorporating PEG, the water sensitivity increased slightly, with a contact angle (CA) of 97.

The Association Between Shift Work, Sleep Quality, and Health-Related Quality of Life Among Workers in the Logistics Industry.

The booming online shopping industry has accelerated the growth of logistic services, often subjecting workers to irregular schedules. This study aims to examine the association between night-shift work and health-related quality of life among logistics workers, with a special focus on the mediating role of sleep characteristics. A survey was conducted among logistics workers across China, who filled out an online questionnaire.

Hydroxyl-based acid-hypersensitive acetal ester bond: Design, synthesis and the application potential in nanodrugs.

Targeted drug delivery systems exploiting the acidic tumor microenvironment have been thriving, with responsive modifications to the active sites like hydroxyl groups enhancing stability, reducing toxicity, and boosting targeted bioavailability. Yet, the utility of hydroxyl-based acid-sensitive linkages is currently constrained by the intricacy of synthesis, questionable stability, and an inability to discern between physiological pH levels associated with health and disease. Here, we unveiled a novel hydroxyl-based acid-labile linkage, the "acetal ester bond", which not only excelled in its hypersensitive acid responsiveness, but was also facile to synthesize, with exceptionally high yields (>80 %) of final products derived from primary, linear secondary, cyclic secondary, and tertiary alcohols consistently, demonstrating its broad applicability.

Electrical Stimulation Therapy - Dedicated to the Perfect Plastic Repair.

Tissue repair and reconstruction are a clinical difficulty. Bioelectricity has been identified as a critical factor in supporting tissue and cell viability during the repair process, presenting substantial potential for clinical application. This review delves into various sources of electrical stimulation and identifies appropriate electrode materials for clinical use.

Field-road classification for agricultural vehicles in China based on pre-trained visual model.

Field-road classification that automatically identifies the activity (either in-field or on-road) of each point in Global Navigation Satellite System (GNSS) trajectories is a critical process in the behavior analysis of agricultural vehicles. To capture movement patterns specific to agricultural operations, we propose a multi-view field-road classification method, which extracts a physical and a visual feature vector to represent a trajectory point. We propose a task-specific approach using a pre-trained visual model to effectively extract visual features.

Current status and risk determinants of locomotive syndrome in geriatric cancer survivors in China-a single-center cross-sectional survey.

Objective: To assess the prevalence and risk determinants of locomotive syndrome (LS) in geriatric cancer survivors in China. To generate evidence-based insights for the clinical prevention and intervention strategies concerning LS in this vulnerable population, emphasizing the need for integrated public health initiatives focused on maintaining mobility among geriatric cancer survivors.

Methods: Six hundred geriatric cancer survivors were recruited at a hospital in China.

DNA target binding-induced pre-crRNA processing in type II and V CRISPR-Cas systems.

Precursor (pre)-CRISPR RNA (crRNA) processing can occur in both the repeat and spacer regions, leading to the removal of specific segments from the repeat and spacer sequences, thereby facilitating crRNA maturation. The processing of pre-crRNA repeat by Cas effector and ribonuclease has been observed in CRISPR-Cas9 and CRISPR-Cas12a systems. However, no evidence of pre-crRNA spacer cleavage by any enzyme has been reported in these systems.

Effect of long-term exposure to non-biodegradable and biodegradable microplastics in continuous anoxic/aerobic bioreactors: Nitrogen removal performance, microbial communities and functional gene responses.

The environmental hazards caused by microplastics (MPs) have received widespread attention, but the effects of non-biodegradable and biodegradable MPs of long-term presence on continuously operating sewage treatment bioreactors are not well known. In this study, we investigated the effect of a representative non-biodegradable MP, polyethylene terephthalate (PET), and a biodegradable MP, polylactic acid (PLA), on the nitrogen removal performance of conventional anoxic/aerobic (A/O) process. The NH-N removal efficiencies were suppressed to 91.

Developing a new index with time series Sentinel-2 for accurate tidal flats mapping in China.

Tidal flats are essential habitats for a wide variety of plants and animals along the coast, contributing significantly to biodiversity preservation. Despite efforts to employ remote sensing technology for mapping these areas, misidentification remains a persistent issue. Within the context of tidal flat mapping, one of the primary challenges lies in distinguishing between tidal flats and turbid water bodies.

Construction of a risk prediction model for isolated pulmonary nodules 5-15 mm in diameter.

Background: Based on current technology, the accuracy of detecting malignancy in solitary pulmonary nodules (SPNs) is limited. This study aimed to establish a malignant risk prediction model for SPNs 5-15 mm in diameter.

Methods: We collected clinical characteristics and imaging features from 317 patients with SPNs 5-15 mm in diameter from the 900th Hospital of the Joint Logistic Support Force as a training cohort and 100 patients with SPNs 5-15 mm in diameter as a validation cohort.