Publications by authors named "Yindi Hu"
Cancer‑induced bone pain (CIBP) is characterized as moderate to severe pain that negatively affects the daily functional status and quality of life of patients. When cancer cells metastasize and grow in bone marrow, this activates neuroinflammation in the spinal cord, which plays a vital role in the generation and persistence of chronic pain. In the present study, a model of CIBP was constructed by inoculating of MRMT‑1 rat breast carcinoma cells into the medullary cavity of the tibia in male Sprague‑Dawley rats.
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- The process starts with a three-component reaction involving 2-aminopyridine, 2-azidobenzaldehydes, and isocyanides, leading to azide intermediates without needing to separate them.
- Initial tests show that the resulting compounds can effectively inhibit glioma cells, highlighting potential uses in both synthesis and medicinal chemistry.
Article Synopsis
- Chronic pain from osteoarthritis makes it hard for patients to live their everyday lives.
- A study done on mice showed that a special treatment called lycorine helped reduce pain and improve movement by calming down inflammation in the spinal cord.
- Lycorine works by stopping certain harmful proteins and increasing helpful ones, which makes the pain from arthritis better.
Proteomic analysis of spinal cord tissue in a rat model of cancer-induced bone pain.
Front Mol Neurosci
December 2022
Background: Cancer-induced bone pain (CIBP) is a moderate to severe pain and seriously affects patients' quality of life. Spinal cord plays critical roles in pain generation and maintenance. Identifying differentially expressed proteins (DEPs) in spinal cord is essential to elucidate the mechanisms of cancer pain.
View Article and Find Full Text PDFChronic pain is the predominant problem for rheumatoid arthritis patients, and negatively affects quality of life. Arthritis pain management remains largely inadequate, and developing new treatment strategies are urgently needed. Spinal inflammation and oxidative stress contribute to arthritis pain and represent ideal targets for the treatment of arthritis pain.
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