The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation.

Introduction: The aim was to devise an animal model showing some of the neuropathological changes seen in senile dementia, and to investigate the effect of celastrol on cognition neuropathology in this model.

Material And Methods: Forty male Sprague Dawley rats weighing 300-350 g were randomly divided into 5 groups ( = 8 each): control (Con); inhaled sevoflurane (Sev); diabetes mellitus (DM); diabetes mellitus + inhaled sevoflurane (DM/Sev); diabetes + inhaled sevoflurane + celastrol (Cel). Diabetes was induced by an intraperitoneal injection of streptozotocin (STZ).