Investigation of the causal relationship between patient portal utilization and patient's self-care self-efficacy and satisfaction in care among patients with cancer.

Objective: The objective of this study was to examine the causal relationship between the usage of patient portals and patients' self-care self-efficacy and satisfaction in care outcomes in the context of cancer care.

Methods: The National Institute's HINTS 5 Cycle 1-4 (2017-2020) data were used to perform a secondary data analysis. Patients who reported being ever diagnosed with cancer were included in the study population.

A predictive model for depression risk in individuals with hypertension: evidence from NHANES 2007-2020.

Objective: Hypertension increases the prevalence of depression to a certain extent and identification and diagnosis of depression frequently pose challenges for clinicians. The study aimed to construct and validate a scoring model predicting the prevalence of depression with hypertension.

Methods: 6124 individuals with hypertension were utilized from the 2007 to 2020 National Health and Nutrition Examination Survey database (NHANES), including 645 subjects that were assessed to have depressive symptoms, 390 in the development group and 255 in the validation group.

Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis.

Mendelian randomization (MR) was employed to investigate the causal relationships between immune cell phenotypes, hyperthyroidism (HD), and potential metabolic mediators. In this study, we acquired 731 immune cell phenotypes from genome-wide association studies (GWAS) (n = 18,622), HD data from the research by Handan Melike Dönertaş et al. (3,731 cases, 480,867 controls), and aggregated statistics of 1,400 blood metabolites from UK Biobank (n = 115,078).

Unpacking multidimensional effects of economic restructuring and technological progress on carbon emission performance: the moderating role of environmental regulation.

The growth in carbon emissions poses a severe challenge to global sustainable development, making it imperative to explore the impacts of economic restructuring and technological progress on Carbon Emission Performance (CEP). However, existing studies often lack an integrated analysis of economic restructuring and technological progress, while giving limited attention to the indirect role of Environmental Regulation (ER). This study constructs a multidimensional theoretical framework, breaking down economic restructuring into four dimensions-industrial structure, factor input, ownership, and new-type urbanization (NTU), and refining technological progress into technological innovation and energy efficiency.

A Single-Arm, Open-Label, Phase Ib Clinical Study Evaluating the Efficacy and Safety of Durvalumab in Combination with Albumin-Bound Paclitaxel and Carboplatin as Neoadjuvant Therapy for Resectable Stage III Non-Small Cell Lung Cancer.

Objective: This study aimed to explore the clinical efficacy and safety of durvalumab combined with albumin-bound paclitaxel and carboplatin as neoadjuvant therapy for resectable stage III Non-small Cell Lung Cancer (NSCLC).

Methods: A single-arm open-label phase Ib study was conducted. A total of 40 patients with driver gene-negative resectable stage III NSCLC were enrolled.

Deciphering the Evolution of Current Distribution in Hybrid Silver Vanadium Oxide / Carbon Monofluoride Cathodes within Lithium Primary Batteries.

For batteries to function effectively all active material must be accessible requiring both electron and ion transport to each particle. A common approach to generating the needed conductive network is the addition of carbon. An alternative approach is the electrochemically induced formation of conductive reaction products generated with intimate contact to the active material.

Deep Learning-Based Super-Resolution Reconstruction on Undersampled Brain Diffusion-Weighted MRI for Infarction Stroke: A Comparison to Conventional Iterative Reconstruction.

Background And Purpose: DWI is crucial for detecting infarction stroke. However, its spatial resolution is often limited, hindering accurate lesion visualization. Our aim was to evaluate the image quality and diagnostic confidence of deep learning (DL)-based super-resolution reconstruction for brain DWI of infarction stroke.

The Space Radiobiological Exposure Facility on the China Space Station.

The Space Radiobiological Exposure Facility (SREF) is a general experimental facility at the China Space Station for scientific research in the fields of space radiation protection, space radiation biology, biotechnology, and the origin of life. The facility provides an environment with controllable temperatures for experiments with organic molecules and model organisms such as small animals, plant seeds, and microorganisms. The cultivation of small animals can be achieved in the facility with the use of microfluidic chips and images and videos of such experiments can be captured by microscopy.

Coordination of Focal Adhesion Nanoarchitecture and Dynamics in Mechanosensing for Cardiomyoblast Differentiation.

Focal adhesions (FAs) are force-bearing multiprotein complexes, whose nanoscale organization and signaling are essential for cell growth and differentiation. However, the specific organization of FA components to exert spatiotemporal activation of FA proteins for force sensing and transduction remains unclear. In this study, we unveil the intricacies of FA protein nanoarchitecture and that its dynamics are coordinated by a molecular scaffold protein, BNIP-2, to initiate downstream signal transduction for cardiomyoblast differentiation.

Benchmarking cross-species single-cell RNA-seq data integration methods: towards a cell type tree of life.

Cross-species single-cell RNA-seq data hold immense potential for unraveling cell type evolution and transferring knowledge between well-explored and less-studied species. However, challenges arise from interspecific genetic variation, batch effects stemming from experimental discrepancies and inherent individual biological differences. Here, we benchmarked nine data-integration methods across 20 species, encompassing 4.

From Marine Debris to a Valuable Medical Resource: A review on biology, chemistry, ethnopharmacology, bioactivity and application in biomedical materials of Cuttlebone.

Ethnopharmacological Relevance: Cuttlebone (CB), also known as SEPIAE ENDOCONCHA, is the inner shell of cuttlefish and has been employed in traditional medicine in numerous countries since antiquity. Despite its significant medicinal value, CB is often underestimated and discarded on the beach as debris in some countries, which considerably impacts the environment and economy.

The Aim Of The Review: This study aims to elucidate the value of CB, particularly in the context of its medicinal properties, to promote its rational utilization.

Targeting macrophages in cancer immunotherapy: Frontiers and challenges.

Background: Cancer immunotherapy has emerged as a groundbreaking approach in cancer treatment, primarily realized through the manipulation of immune cells, notably T cell adoption and immune checkpoint blockade. Nevertheless, the manipulation of T cells encounters formidable hurdles. Macrophages, serving as the pivotal link between innate and adaptive immunity, play crucial roles in phagocytosis, cytokine secretion, and antigen presentation.

Co-activating STING-TLR9 pathways promotes radiotherapy-induced cancer vaccination.

Vaccination may cure cancer patients by inducing tumor-specific immune responses. Radiotherapy is an appealing strategy to generate cancer vaccines in situ; thus far, however, only modest and short-lived immune responses are achieved. We here show that radiation combined with co-activating STING-TLR9 can generate powerful in situ cancer vaccines.

Soil aggregation alterations under soil microplastic and biochar addition and aging process.

Soil microplastics (MPs) are a substantial threat to soil health, particularly by disrupting soil aggregation. Additionally, MPs undergo aging processes in the soil, which may significantly alter their long-term impacts on soil structure. To investigate these effects, we conducted an eight-month soil incubation experiment, examining the influence of MPs and their aging on soil aggregation.

Association between the Achievement of Textbook Outcomes in Liver Surgery (TOLS) and Overall Survival in Perihilar Cholangiocarcinoma Patients Following Major Hepatectomy: A Multicenter Study.

Introduction Major hepatectomy is the mainstay of curative-intent resection for perihilar cholangiocarcinoma (pCCA) patients. Textbook Outcomes in Liver Surgery (TOLS) are a new composite parameter for evaluating the short-term outcomes of surgery; however, their association with overall survival (OS) is unknown. Therefore, this study aimed to investigate the association between TOLS and OS in pCCA patients following major hepatectomy.

Modeling regional private income and its embedded carbon emissions: sources, flows and inequalities.

Composing regional total income jointly with government income, private income represents levels of development and affluence from the household perspective. Considering the need for fair carbon emission reduction responsibility distributions among regions with divergent income levels, private income-embedded emission (PIEE) and the inter-regional inequalities remain to be explored. Combining input-output analysis and the Gini coefficient, this study traces the sources and disposals of regional private income in China, as well as their embedded carbon emission flow, and quantifies the distribution and inequality of PIEE across industrial sectors and provincial regions.

Impact of normocapnia vs. mild hypercapnia on prognosis after cardiac arrest: A systematic review and meta-analysis.

Objective: To explore the impact of mild hypercapnia or normocapnia on the prognosis of patients after the return of spontaneous circulation (ROSC) following cardiac arrest (CA).

Methods: This systematic review and meta-analysis followed the guidelines in the PROSPERO report. Information was retrieved in PubMed, Cochrane Library, Embase, and Web of Science to collect all publications in English from January 1, 2000, to March 1, 2024, involving post-CA with mild hypercapnia.

Hesperidin enhances broiler growth performance by augmenting gastric acid secretion via the proton pump pathway.

Hesperidin exhibits promising potential as a feed additive for augmenting gastric acid secretion in animals. Gastrointestinal function is essential for animal growth and the efficient digestion of dietary nutrients, with gastric acid secretion serving as one of its critical components. The secretion of gastric acid, together with other digestive fluids and substances, significantly influences the digestion and absorption of animal feed, which in turn affects growth performance.

Characteristic of Immunotherapy Trials in Head and Neck Squamous Cell Carcinoma: 2013-2023.

Objective: This research provides a comprehensive analysis of immunotherapy clinical trials for head and neck squamous cell carcinoma, aiming to enhance future trial designs.

Methods: We analyzed all clinical trials focused on head and neck squamous cell carcinoma immunotherapy registered on ClinicalTrials.gov from January 1st, 2013, to December 31st, 2023, examining general characteristics, methodological features, and types of immunotherapeutic drugs.

[Electroacupuncture combined with ear tip bloodletting for 60 cases of insomnia with phlegm-fire disturbing heart].

Objective: To observe the clinical efficacy of electroacupuncture combined with ear tip bloodletting for insomnia with phlegm-fire disturbing heart.

Methods: A total of 60 cases with insomnia of phlegm-fire disturbing heart were selected, and the treatment of electroacupuncture combined with ear tip bloodletting was delivered. Acupuncture was applied at Yintang (GV24), Shenting (GV24), Sishencong (EX-HN1) and bilateral Shenmen (HT7), Quchi (LI11), Zhaohai (KI6), Shenmai (BL62), Fenglong (ST40), Neiting (ST4), Yintang (GV24) and Shenting (GV24) were connected to electroacupuncture, continuous wave, 2 Hz in frequency.

Biomimetic Cerium-Assisted Supra-Carbon Dots Assembly for Reactive Oxygen Species-Activated Atherosclerosis Theranostic.

Theranostic applications in atherosclerosis plaque microenvironment-triggered nanoplatforms are significantly compromised by the complex synthesis procedure, non-specific distribution, and limited therapeutic function. Therefore, development of a facile and feasible method to construct a pathology-based stimuli-responsive nanoplatform with satisfactory theranostic performance remains a demanding and highly anticipated goal. Herein, a novel class of multifunctional supra-carbon dots (CDs), denoted as MM@Ce-CDs NPs, by a simple nanoassembly and a subsequent coating with macrophage membrane (MM), is developed for the targeted reactive oxygen species-trigged theranostic and positive regulation of the pathological plaque microenvironment in AS.

Porous Supramolecular Crystalline Materials for Photocatalysis.

Porous supramolecular crystalline materials (PSCMs), usually including hydrogen-bonded organic frameworks (HOFs), π frameworks, and so on, can be defined as a type of porous supramolecular assemblies stabilized by hydrogen-bonding, π-π stacking and other non-covalent interactions. Given the unique features of mild synthetic conditions, well-defined and tailorable structures, easy healing and regeneration, PSCMs have captured widespread interest in molecular recognition, sensor, gas storage and separation, and so on. Moreover, they currently emerge as promising photocatalysts because it is readily to endow PSCMs with photo-function, and the hydrogen-bonding and π-π stacking can serve as electron transfer channels to boost photocatalytic activity.

Untangling the Role of Capping Agents in Manipulating Electrochemical Behaviors Toward Practical Aqueous Zinc-Ion Batteries.

Long-standing challenges including notorious side reactions at the Zn anode, low Zn anode utilization, and rapid cathode degradation at low current densities hinder the advancement of aqueous zinc-ion batteries (AZIBs). Inspired by the critical role of capping agents in nanomaterials synthesis and bulk crystal growth, a series of capping agents are employed to demonstrate their applicability in AZIBs. Here, it is shown that the preferential adsorption of capping agents on different Zn crystal planes, coordination between capping agents and Zn ions, and interactions with metal oxide cathodes enable preferred Zn (002) deposition, water-deficient Zn ion solvation structure, and a dynamic cathode-electrolyte interface.

The role of B cells in the pathogenesis of type 1 diabetes.

Type 1 diabetes (T1D) is a metabolic disorder caused by a complete lack of insulin, primarily manifested by hyperglycemia. The mechanisms underlying the onset of T1D are complex, involving genetics, environment, and various unknown factors, leading to the infiltration of various immune components into the islets. Besides T cells, B cells are now considered important contributors to the pathogenesis of T1D, according to recent studies.