Hybrid membrane based biomimetic nanodrug with high-efficient melanoma-homing and NIR-II laser-amplified peroxynitrite boost properties for enhancing antitumor therapy via effective immunoactivation.

Owing to the excellent stability, anticancer activity and immunogenicity, peroxynitrite (ONOO) has been gained enormous interests in cancer therapy. Nevertheless, precise delivery and control release of ONOO in tumors remains a big challenge. Herein, B16F10 cancer cell membrane/liposome hybrid membrane (CM-Lip) based biomimetic nanodrug with high-efficient tumor-homing and NIR-II laser controlled ONOO boost properties was designed for melanoma treatment.