The Impact of Preventive Strategies Adopted during Large Events on the COVID-19 Pandemic: A Case Study of the Tokyo Olympics to Provide Guidance for Future Large Events.

This study aimed to analyze the impact of hosting large events on the spread of pandemics, taking Tokyo Olympics 2020 as a case study. A risk assessment method for the whole organization process was established, which could be used to evaluate the effectiveness of various risk mitigation measures. Different scenarios for Games participants and Japanese residents during the Tokyo Olympics were designed based on the infection control protocols proposed by the Olympic Committee and local governments.

Reduced plasma progranulin levels are associated with the severity of Parkinson's disease.

Blood levels of progranulin (PGRN) are suggested to be decreased in patients with Parkinson's disease (PD). However, the association between blood levels of progranulin and the severity of PD is not yet clear. A total of 55 PD patients and 55 normal control (NC) subjects were recruited in the present study.

MicroRNA-217/138-5p downregulation inhibits inflammatory response, oxidative stress and the induction of neuronal apoptosis in MPP-induced SH-SY5Y cells.

Parkinson's disease (PD) is a common neurodegenerative disease. Various microRNAs (miRNAs) have been reported to play important roles in cell growth regulation and inflammatory reaction. However, the detailed roles of miR-217 and miR-138-5p in PD progression remain to be investigated.