Post-translational modifications (PTMs) of proteins play a crucial role in living organisms, altering the properties and functions of proteins. There are over 450 known PTMs involved in various life activities. LSD1 (lysine-specific demethylase 1) is the first identified histone demethylase that can remove monomethylation or dimethylation modifications from histone H3 lysine K4 (H3K4) and histone H3 lysine K9 (H3K9).
View Article and Find Full Text PDFWhite-light scanning interferometry is a mature non-contact three-dimensional shape detection method. However, the batwing effect is an inherent problem that causes systematic error. In this paper, we proposed an algorithm for detecting and eliminating the batwing effect based on the Haar wavelet transforms without any prior knowledge of the sample surface.
View Article and Find Full Text PDFFront Pharmacol
July 2023
[This corrects the article DOI: 10.3389/fphar.2023.
View Article and Find Full Text PDFHepatic fibrosis is a progressive condition, often attributed to metabolic disorders, which may promote cirrhosis and liver cancer. derived from have been shown to have a therapeutic effect on liver fibrosis but little is known about the molecular mechanisms involved. To investigate the metabolic modulations produced by in liver fibrosis.
View Article and Find Full Text PDFTiC-TiSiC gradient hybrid interphase on the surface of SiC fibers was successfully obtained through the molten salt method. The electromagnetic parameters of the prepared samples can be accurately controlled by adjusting the reaction temperature. A significant bimodal effect is observed in electromagnetic parameters patterns, corresponding to the double interface layer.
View Article and Find Full Text PDFBackground: Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC. It has been reported that LSD1 repressed tumor immunity through programmed cell death 1 ligand 1 (PD-L1) in melanoma and breast cancer. The role of LSD1 in the immune microenvironment of GC is unknown.
View Article and Find Full Text PDFSex differences are evident in the incidence and mortality of diverse cancers. With the development of personalized approaches in cancer treatment, the impact of sex differences has not been systematically incorporated into preclinical and clinical cancer research. The molecular mechanisms underlying sex differences in cancer have not been elucidated.
View Article and Find Full Text PDFCoNiFe₂O₄ fibers with a diameter of about 270 nm and a length of about 10 μm were synthesized by a microemulsion-mediated solvothermal method with subsequent heat treatment. The CoNiFe₂O₄ fibers/reduced graphene oxide (RGO) composite was prepared by a facile in-situ chemical reduction method. The crystalline structures and morphologies were investigated based on X-ray diffraction patterns and scanning electron microscopy.
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