Publications by authors named "Yin-tao Shang"
[Inhibitory Effect of Resveratrol on the Proliferation of Multiple Myeloma Cells and the Underlying Mechanism].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2023
Article Synopsis
- * RSV treatment resulted in reduced MM cell proliferation and increased apoptosis in a time- and dose-dependent manner.
- * The study found that RSV inhibits the expression of miR-21, leading to cell cycle alterations and promoting apoptosis, suggesting it could be a potential therapeutic agent for MM.
[Clinical Analysis of 12 cases of Systemic Lupus Erythematosus Associated with Thrombotic Thrombocytopenic Purpura].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
August 2017
Objective: To investigate the clinical manifestations, treatment strategies and outcomes of 12 patients with systemic lupus erythematosus (SLE) associated with thrombotic thrombocytopenic purpura(TTP).
Methods: The clinical data from 12 cases of SLE associated with TTP admitted in the Second Hospital of Hebei Medical University from January 2002 to August 2015 were retrospectively analyzed.
Results: 12 cases of SLE associated with TTP included 11 females and 1 male, their median age was 34.
[BMMSC from blastic phase CML down-regulate leukemia cell apoptosis].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
October 2014
The purpose of this study was to investigate the effect of bone marrow mesenchymal stem cells (BMMSC) from patients with chronic myeloid leukemia (CML) in blastic phase (Bp) on K562 cells and the primary CML-Bp cells, and to explore its potential mechanisms. K562 cells and primary CML-Bp cells were co-cultured with BMMSC of different groups; the cell proliferation was detected by MTT method, the cell apoptosis rate and mitochondrial membrane potential were measured by flow cytometry, the expression levels of Caspase-8, Caspase-9, and activated Caspase-3 in cells were measured by Western blot. The results showed that the CML-Bp BMMSC could enhance the survival rate of K562 cells treated with adviamycin (ADM) and display protective effect on K562 cells and primary CML-Bp mononuctear cells, inhibited ADM-induced leukimia cell apoptosis (P < 0.
View Article and Find Full Text PDF[Inhibitory effects of rapamycin on proliferation of chronic myelogenous leukemia cells and its mechanism].
Zhonghua Xue Ye Xue Za Zhi
October 2012
Objective: To explore the inhibitory effects of rapamycin on proliferation of chronic myelogenous leukemia (CML) cells and its possible mechanism.
Methods: The effects of rapamycin at various concentrations on cell proliferation of CML cell line K562 cells were analyzed by MTT. The expressions of mTOR, 4E-BP1 and p70S6K at protein and mRNA level in K562 cells with rapamycin treatment were detected by Western blot and RT-PCR.