Publications by authors named "Yin-kai Zhang"
Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, we performed a meta-analysis. The PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases were searched for case-control studies that were published up to January 2013.
View Article and Find Full Text PDFArticle Synopsis
- A meta-analysis was conducted to investigate the link between the GSTM1 null gene polymorphism and oral cancer risk, incorporating 39 studies with a total of 4,704 cases and 7,090 controls.
- The overall pooled odds ratio indicated a 29% increased risk of oral cancer associated with the null gene variant, although significant variation was noted across the studies.
- Stratified analysis revealed a significant association in Asian populations (OR = 1.39) but no risk increase was found in Caucasian populations (OR = 0.99).
Vascular endothelial growth factor (VEGF) is considered as a prime mediator of angiogenesis and has been implicated in carcinogenesis and metastasis. Various studies examined the relationship between VEGF protein overexpression with the clinical outcome in patients with oral cancer, but yielded conflicting results. Electronic databases updated to March 2013 were searched to find relevant studies.
View Article and Find Full Text PDF[Effect of disc displacement on mRNA expression of urokinase plasminogen activator and its inhibitor-1 in synovial tissues].
Hua Xi Kou Qiang Yi Xue Za Zhi
February 2006
Objective: To investigate the effect of anterior disc displacement on the expression of urokinase plasminogen activator and its inhibitor-1 (uPA/PAI-1) in synovial tissues.
Methods: Forty Japanese white rabbits were used in this study. The animals were killed at 4 days, 1, 2, 4, 8 and 12 weeks postoperatively, respectively.
Purpose: To investigate the source of the metaplasia chondrocytes in the bilaminar zone following anterior disc displacement (ADD) of temporomandibular joint (TMJ).
Methods: 12 Japanese adult rabbits were randomly divided into A and B groups. Each group contained 4 experimental and 2 control rabbits.
Background: The urokinase plasminogen activator system is believed to play an important role in degradation of the extracellular matrix associated with cartilage and bone destruction; however its precise roles in temporomandibular disorders have not yet been clarified. The aims of this study were to investigate the gene expression of fibrinolytic factors urokinase plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in the articular cartilage of rabbit temporomandibular joint (TMJ) with disc displacement (DD) and to probe the relationship between fibrinolytic activity and cartilage remodeling.
Methods: Disc displacement of right joints was performed in 36 of 78 rabbits under investigation.
[The morphology of the cells in the cartilage of rabbit mandibular condyle].
Shanghai Kou Qiang Yi Xue
February 2005
Purpose: To study the tissue layers and their function of the cartilage in mandibular condyle in rabbits.
Methods: Six adult Japanese white rabbits were subjected. Their temporomandibular joints were studied by immunohistochemistry for FGFR3 and PCNA, and in situ hybridization for aggrecan and collagen II mRNA expression, as well as ultrastructure.
Objective: To investigate the relationship of vascular endothelial growth factor C (VEGF-C) and induced nitride oxide synthesizase (iNOS) expression in lymph node micrometastasis of oral squamous cell carcinoma.
Methods: Samples were obtained from 47 cases of oral squamous cell carcinoma and 15 cases with normal oral mucosa, VEGF-C and iNOS mRNA expression were detected by RT-PCR method. Lymph node micrometastasis of 10 normal lymph nodes and 355 lymph nodes from 47 cases of oral squamous cell carcinoma was detected with immunohistochemical reaction in cytokeratin antibody.
[The relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma].
Zhonghua Kou Qiang Yi Xue Za Zhi
May 2004
Objective: To probe the relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma.
Methods: The microlymphatic vessel density was detected with enzyme histo-chemical method in 47 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa; 355 lymphnodes were detected with immunohistochemically using monoantibody AE3.
Results: The mean MLVD was 14.
Objective: To study the adaptive alteration in bilaminar zone of rabbits' temporomandibular joint following disc displacement.
Methods: Twenty-six Japanese white rabbits were used in this study. Among these rabbits,6 were used as controls.