Publications by authors named "Yin-jiu Huang"
Telomere and telomerase were closely related to occurrence and development of some cancers. To enhance ability of myricetin moiety for inhibiting telomerase, we designed a series of novel myricetin derivatives based on reasonable analysis. The telomerase inhibition assay showed that compound 6d displayed the most potent inhibitory activity with IC50 value of 0.
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- Cervical cancer is a prevalent and rising issue among females, prompting urgent needs for new anticancer drugs.
- A newly discovered compound, LG003, showed strong anticancer effects against the SiHa cervical cancer cell line, outperforming several standard treatments.
- LG003's effectiveness is dependent on time and dose, and it induces cell death by causing apoptosis and damaging cell membranes through a physiological pathway, indicating its potential as a cervical cancer therapy.
A series of 4-(4-substituted piperazin)-5,6,7-trialkoxy quinazoline was prepared by conventional heating methods. Among these compounds, the crystal structure of compound 10o (CCDC: 916922) was determined by X-ray crystallography. Bioassay results showed that most target compounds had certain inhibition activities against proliferation of tumor cells, and some compounds even had good broad-spectrum inhibition activities.
View Article and Find Full Text PDF[Antibacterial mechanism of sulforaphane on Escherichia coli].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2012
Objective: To investigate the antibacterial mechanism of sulforaphaneon (SFN) on Escherichia coli.
Methods: To determine membrane penetrability, changes of SDS-PAGE protein spectra, soluble protein and alkaline phosphatase and reducing sugar were determined. Cellular nucleic acid synthesis was detected by 4, 6- diamidino-2-phenylindole (DAPI) staining assay.