Population pharmacokinetic characteristics of sirolimus in healthy Chinese subjects and renal transplant patients.

Aim: To identify the factors affecting the pharmacokinetics (PKs) of sirolimus in healthy Chinese subjects and renal transplant patients.

Methods: A population PK model of sirolimus was constructed using dense data from 22 healthy volunteers and sparse data from 105 renal transplant patients.

Results: The data were well described by a two-compartment model with first-order absorption.