Publications by authors named "Yin-Yong Zhang"
Article Synopsis
- - Neuroinflammation caused by microglia is a major factor in neurodegenerative diseases, and Lappaconitine (LA), derived from a plant, has been found to reduce certain inflammatory responses in cells.
- - Researchers synthesized and tested LA analogues for their ability to inhibit nitric oxide production in microglia, with one compound (compound 10) showing the strongest effect.
- - Compound 10 works by inhibiting a specific inflammatory pathway in microglia and appears to be safer than LA in toxicity tests, suggesting it could be a promising candidate for treating neuroinflammation.
Natural products and their derivatives are a precious treasure in the pursuit of potent anti-inflammatory drugs. In this work, we measured the toxicity of 78 LA derivatives at 20 μM using MTT, then we evaluated the NO release of compounds without obvious toxicity in LPS-induced RAW.264.
View Article and Find Full Text PDF