Publications by authors named "Yin-Xu Zhao"
This study investigated the effects of ergosterol peroxide(EP) on the proliferation and apoptosis of MCF-7 breast cancer cells, explored its possible mechanisms of action, and verified the effects and mechanisms by in vitro experiments. Network pharmaco-logy was used to screen the target proteins of EP and construct target networks and protein-protein interaction(PPI) networks to predict the potential target proteins and related pathways involved in EP anti-breast cancer effects. The MTT assay was performed to measure the inhibitory effect of EP on MCF-7 cell proliferation, and the colony formation assay was used to assess the cell cloning ability.
View Article and Find Full Text PDF[Ergosterol peroxide inducing apoptosis of human hepatocellular carcinoma by regulating mitochondrial apoptosis pathway].
Zhongguo Zhong Yao Za Zhi
June 2024
Article Synopsis
- This study looked at how a substance called ergosterol peroxide (EP) affects cancer cells in the liver, specifically a type called hepatocellular carcinoma.
- Researchers tested different amounts of EP to see how well it stopped these cancer cells from growing over different periods (24, 48, and 72 hours).
- The results showed that EP not only increased the number of dying cancer cells but also changed some important proteins in those cells, suggesting that EP helps to kill cancer cells by affecting their energy factories, called mitochondria.