Publications by authors named "Yin-Ting Ma"
Natural killer (NK) cells were reported to be involved in the pathogenesis of primary antiphospholipid syndrome (pAPS). Immunosuppressive receptor T-cell immunoreceptor with Ig and ITIM domains (TIGIT) and activating receptor cluster of differentiation 226 (CD226) are specifically expressed on NK cells with competitive functions. This study aims to investigate the expression diversities of CD226/TIGIT on NK subsets and their associations with NK subsets activation phenotypes and potential clinical significance, furthermore, to explore potential cause for CD226/TIGIT expression diversities in pAPS.
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- The study investigated the link between specific genetic variations (SNPs) in the MTHFR and APOE genes and the risk and severity of coronary artery disease (CAD) among the Chinese Han population.
- A total of 1,207 patients were screened, resulting in 406 CAD cases and 231 control subjects, with CAD severity assessed by cardiologists using Gensini scores and genetic analyses conducted via PCR and Sanger sequencing.
- Findings indicated that certain MTHFR genotypes were more prevalent in CAD patients, suggesting an increased risk, while no significant difference was found in APOE genotypes; additionally, CAD patients with specific MTHFR and APOE genotypes tended to show more severe disease.
Objective: To investigate the association between CYP2C19 and ABCB1 polymorphisms and clopidogrel resistance (CR) in patients with cardiovascular disease in Beijing district.
Methods: In total, 325 patients were enrolled in the study, including 101 experimental group patients and 224 control group patients. The experimental group was divided into CR group (n=30) and non-CR group (n=71) according to the adenosine diphosphate (ADP)-induced platelet inhibition rate in thromboelastography (TEG) (ADP-induced platelet inhibition rate of <30% was defined as CR and rate of 30%-100% was defined as non-CR).