Publications by authors named "Yin-Ming Liang"
CTGF regulated by ATF6 inhibits vascular endothelial inflammation and reduces hepatic ischemia-reperfusion injury.
Biochim Biophys Acta Mol Basis Dis
December 2024
Article Synopsis
- Vascular endothelial inflammation plays a key role in hepatic ischemia-reperfusion injury (IRI), and connective tissue growth factor (CTGF) secreted by endothelial cells is protective against liver damage but its regulatory mechanisms are unclear.
- The study investigates how ATF6, activated by endoplasmic reticulum stress, regulates CTGF to mitigate inflammation and liver damage during IRI, finding that ATF6 enhances CTGF expression while inhibiting inflammatory responses.
- Clinical evidence shows a rise in CTGF post-IRI, which inversely correlates with inflammatory cytokines, suggesting that targeting the ATF6-CTGF pathway could be a new strategy for diagnosing and treating liver IRI.
Article Synopsis
- T lymphopenia happens during sepsis, making infections worse due to a lack of T cells that help control inflammation.
- Researchers found that a special protein called soluble CD4 (sCD4) interacts with another protein on immune cells called MHC II to help reduce this harmful inflammation.
- This interaction prevents overactivation of other proteins that cause inflammation, suggesting that using sCD4 could be a helpful new way to treat sepsis and control inflammation in the body.
Article Synopsis
- - The Monkey-pod tree (Jack Benth.) is a perennial tree from the Fabaceae family, commonly found in Guangdong, Fujian, and Zhejiang provinces in China, and used in traditional medicine for heat toxicity symptoms.
- - In 2018, around 30 Monkey-pod trees in a commercial plantation in Huizhou, Guangdong showed dieback symptoms, with signs of ambrosia beetle infestation, including white sawdust exudates and discoloration near exit holes.
- - Pathogen identification involved collecting samples from infected trees, culturing them on potato dextrose agar, and isolating 37 fungal colonies, which were analyzed for morphological characteristics and genetic sequences indicating the involvement of a specific fungus associated with
This study was performed to discover SNPs for genetic polymorphism analysis of mitochondrial DNA from wild house mice. Universal primer florescent PCR, fluorescence-based conformation sensitive gel electrophoresis (F-CSGE) and DNA sequencing were conducted to analyze the coding region of mitochondrial DNA. Different types of unknown mutations were recorded by variable F-CSGE patterns without false positive.
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