Change of uterine leiomyoma size during pregnancy and the influencing factors: A cohort study.

Objective: To evaluate the changes of uterine leiomyoma size during pregnancy and determine the factors influencing it.

Methods: A prospective study was conducted from June 2016 to June 2018. Women with pregnancies complicated by leiomyoma were recruited.

Clinical characteristics and outcomes in pregnant women with epilepsy.

Background: Epilepsy in pregnancy can lead to substantial maternal and neonatal morbidity and mortality. Early intervention in pregnant women with epilepsy (WWE), accurate assessment of the severity of their condition, and effective treatment are required to improve maternal and neonatal prognosis. Many obstetricians lack experience in monitoring and treating pregnant WWE.

The clinical characteristics of pregnant women with epilepsy in China.

Background: Epilepsy during pregnancy and puerperium is infrequent, and it can induce severe complications and poor prognosis. Pregnancy in women with epilepsy (WWE) is usually uneventful. Previous studies have mainly focused on the effects of different treatments on prognosis.

Early-life exposure to air pollutants and adverse pregnancy outcomes: protocol for a prospective cohort study in Beijing.

Introduction: The association between early exposure to ambient air pollution and adverse pregnancy outcomes in China is unclear. This study will assess the risk of early-life exposure to air pollutants in Beijing and explore the viability of 8-hydroxydeoxyguanosine (8-OHdG) as a biological indicator to assess oxidative stress induced by early-life exposure to air pollution.

Methods And Analysis: Here 2500 women with singleton pregnancies and their infants will be recruited from the Beijing Obstetrics and Gynecology Hospital.

Improved Fertility Following Enucleation of Intramural Myomas in Infertile Women.

Background: The relationship between intramural myomas and fertility remains unclear. The main debate rests on whether cavity-distorting intramural myomas (CDMs) adversely affect fertility more than non-CDMs. We aimed to compare the effects of enucleating non-CDMs and CDMs on fertility improvement in females with unexplained infertility.

Associations between uterine fibroids and obstetric outcomes in twin pregnancies.

Objective: To examine potential associations between the presence of fibroids and obstetric outcomes in twin pregnancies.

Methods: A prospective cohort study compared obstetric outcomes between individuals with twin pregnancies who did and did not have fibroids. Patients were considered for inclusion if they underwent first-trimester ultrasonography examination, and went on to deliver at the Beijing Obstetrics and Gynecology Hospital between September 1, 2012 and December 31, 2014.

Pregnancy outcomes following different surgical approaches of myomectomy.

Aim: The aim of this study was to compare the feasibility, reliability, safety and pregnancy outcomes following transabdominal myomectomy (TAM) and laparoscopic myomectomy (LM) at Beijing Obstetrics and Gynecology Hospital.

Material And Methods: The study included two parts: between January 2005 and December 2010, data on 157 patients were retrospectively collected; and between January 2011 and January 2013, 111 patients were prospectively collected. All of them had fertility requirements following myomectomy.

Identification of DNA methylation of SOX9 in cervical cancer using methylated-CpG island recovery assay.

The aim of the present study was to identify novel methylation markers for cervical cancer screening and to test the clinical application of the most promising biomarker in cervical scrapings. Methylated-CpG island recovery assay-based microarray analysis was carried out on a discovery set consisting of cervical cancer tissue and normal cervical tissue to identify significantly hypermethylated genes. Five hundred and four CpG islands, corresponding to 378 genes, were differentially methylated between cervical cancer tissue and normal cervical tissue.

[Early stage diagnosis of endometrial cancer based on near infrared spectroscopy and support vector machine].

Near-infrared spectroscopy combined with chemometrics methods for diagnosis of cancer has been reported in literatures. In our study, the NIR spectra of 77 specimens of different physiological stages of endometrium were collected. Spectral data were pretreated firstly by multiplicative scatter correction (MSC), orthogonal signal correction (OSC), and both of them, respectively, and then by SG smoothing.

[Study of near infrared spectral preprocessing and wavelength selection methods for endometrial cancer tissue].

Near infrared spectroscopy was applied to measure the tissue slice of endometrial tissues for collecting the spectra. A total of 154 spectra were obtained from 154 samples. The number of normal, hyperplasia, and malignant samples was 36, 60, and 58, respectively.

[Expression of microRNAs in endometrioid adenocarcinoma].

Objective: To analyze miRNA expression profile of endometrioid adenocarcinoma.

Methods: Collect Endometrium was collected from cancer and park cancer tissue. And the total RNA was extracted.