Publications by authors named "Yin-Ju Liu"
Minks and brown rats are reservoir hosts for many endoparasites including those of the genus Trichinella, a group of parasite nematodes with a worldwide distribution. However, little is known about the prevalence of Trichinella sp. infection in the American mink (Neovison vison) and rats (Rattus norvegicus) in China.
View Article and Find Full Text PDFCerebral coenurosis, caused by the larvae of (, is a fatal central nervous system disease in sheep and other herbivores and occasionally humans. Comparative transcriptomic profiles of the developmental stages of the parasite remain unknown. In this study, RNA sequencing was used to determine the transcriptome profiles of different stages of the life cycle of , including Oncosphere, (Pro with Cyst), and Adult (Adu), as well as scolex-neck proglottids (Snp), immature-mature proglottids (Imp), and gravid proglottids (Grp) of the adult stage.
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- Infection can lead to macrophages adopting an alternatively activated (M2) phenotype, which is connected to a Th2 immune response; this study explored the role of thioredoxin peroxidase-2 (TsTPX2) in modulating this response by activating macrophages.
- TsTPX2 was localized in specific tissues of infected mice, and its presence increased Th2 cytokine production while decreasing Th1 cytokines, demonstrating its ability to shift the immune response balance.
- The transfer of macrophages activated by TsTPX2 into mice resulted in reduced Th1 responses and significantly lower levels of parasitic worms, indicating that TsTPX2 may serve as a promising vaccine candidate for trich