Ten new (-) and nine known (-) austocystins, along with four known anthraquinones (-), were isolated from the culture of NRRL 5856 by bioactivity-guided fractionation. The structures of the new compounds were elucidated by spectroscopic data analysis, X-ray crystallographic study, the modified Mosher's method, [Rh(OCOCF3)]-induced ECD spectral analysis, and comparison of the experimental ECD spectra with those of the similar analogues. Compounds - represent the first examples of austocystins with a C-4' oxygenated substitution.
View Article and Find Full Text PDFObjective: To determine whether ABCB1 gene polymorphisms affect the time course of action of rocuronium in Chinese patients.
Methods: This study included 105 unrelated Chinese patients undergoing general anesthesia with propofol, fentanyl, and rocuronium. Neuromuscular monitoring was performed with calibrated acceleromyography.