Genomic Landscape and Immune Microenvironment Features of Preinvasive and Early Invasive Lung Adenocarcinoma.

Background: Understanding the genomic landscape and immune microenvironment features of preinvasive and early invasive lung adenocarcinoma may provide critical insight and facilitate development of novel strategies for early detection and intervention.

Methods: A total of 80 tumor tissue samples and 30 paired histologically normal lung tissue samples from 30 patients with adenocarcinoma in situ (AIS) (n = 8), minimally invasive adenocarcinoma (MIA) (n = 8), and invasive adenocarcinoma (IAC) (n = 14) were subjected to multiregion whole exome sequencing and immunohistochemistry staining for CD8 and programmed death ligand 1 (PD-L1).

Results: All tumors, including AIS, exhibited evidence of genomic intratumor heterogeneity.

Anion induced diversification from heptanuclear to tetranuclear clusters: syntheses, structures and magnetic properties.

Three new polynuclear complexes, [Co(7)(bm)(12)]·(ClO(4))(2)·13H(2)O (1), [Co(4)(bm)(4)Cl(4)(C(3)H(7)OH)(4)] (2), and [Co(4)(bm)(4)(μ-HCO(2))(2)(μ(2)-HCO(2))(2)(C(3)H(7)OH)(2)] (3) (Hbm = (1H-Benzimidazol)-methanol), have been synthesized and characterized by elemental analysis, IR, powder X-ray diffraction and X-ray single-crystal diffraction. Compound 1 features a centrosymmetric wheel-like heptanuclear Co(II) cluster. Compound 2 having a I4(1)/a space group exhibits a tetranuclear Co(II) cluster with a cubane topology in which the central Co(II) ion and oxygen atoms from bm occupy the alternate vertices of the cube.

2-Eth-oxy-6-[(methyl-imino)-meth-yl]phenol.

In the title compound, C(10)H(13)NO(2), synthesized by the reaction of 2-hy-droxy-3-eth-oxy-benzaldehyde with methyl-amine, there is an an intra-molecular O-H⋯N hydrogen bond involving the hy-droxy substituent and the amino N atom. In the crystal, mol-ecules form inversion dimers connected by pairs of C-H⋯O hydrogen bonds.

Six cases of SCA3/MJD patients that mimic hereditary spastic paraplegia in clinic.

Background: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is an autosomal dominant neurodegenerative disease characterized by cerebellar ataxia associated with varying phenotypic variability. It was reported that a few of SCA3/MJD patients showed marked spastic paraplegia with or without cerebellar ataxia, which was partially first diagnosed as hereditary spastic paraplegia (HSP) and considered to be a new subtype (subtype V). But the data in China is still absent.

[AAA ATPases and hereditary spastic paraplegia].

The hereditary spastic paraplegias (HSPs or SPGs) are clinically and genetically highly heterogeneous neurodegenerative disorders mainly characterized by progressive spasticity and weakness in the lower limbs. The inheritance mode includes autosomal dominant(AD-HSP), autosomal recessive(AR-HSP) and X-linked recessive(XR-HSP). Thirty-five loci have been mapped with 17 disease-associated genes identified.